Category: 86770-80-1

Related Products of 86770-80-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 86770-80-1 name is 3,3-Difluorocyclobutanecarbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound 10-3 (7.0g, 59.78mmol), NH3 ? H2O (7mL) and Raney nickel (7.0g, 100%/W) were dissolved in ethanol (70mL) and the mixture was stirred for 3 hours in H2 (50 psi) atmosphere at room temperature. Then the mixture was filtered, added 10mL of 4M hydrochloric acid methanol solution, and concentrated to give Compound 10-4 (5.5g, 58.4%) as a white solid

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,3-Difluorocyclobutanecarbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; KBP Biosciences Co., Ltd.; ZHANG, Hui; DONG, Yanyan; EP2738156; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 86770-80-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 86770-80-1, name is 3,3-Difluorocyclobutanecarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 125C 3,3-difluoro-1-(4-(trifluoromethyl)pyridin-2-yl)cyclobutanecarbonitrile Example 125B and 2-fluoro-4-(trifluoromethyl)pyridine (0.900 mL, 7.39 mmol) were dissolved in toluene (2.4 mL), cooled to <5 C. and added KHMDS (29.6 mL, 14.78 mmol) dropwise, allowed to warm slowly to room temperature and stirred for 90 minutes. The mixture was diluted with MTBE and washed with water (2*). The organic phase was dried (Na2SO4), filtered, and concentrated. The residue was chromatographed on silica gel (0-25% EtOAc/hexanes) to provide Example 125C (1.22 g, 4.65 mmol, 63.0% yield). 1H NMR (300 MHz, DMSO-d6) delta 9.00-8.94 (m, 1H), 8.04-7.99 (m, 1H), 7.88 (ddd, J=5.1, 1.6, 0.8 Hz, 1H), 3.68-3.48 (m, 5H). The synthetic route of 3,3-Difluorocyclobutanecarbonitrile has been constantly updated, and we look forward to future research findings. Reference:
Patent; AbbVie Inc.; Bayburt, Erol K.; Clapham, Bruce; Cox, Phil B.; Daanen, Jerome F.; Dart, Michael J.; Gfesser, Gregory A.; Gomtsyan, Arthur; Kort, Michael E.; Kym, Philip R.; Schmidt, Robert G.; Voight, Eric A.; US2014/80803; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 86770-80-1, name is 3,3-Difluorocyclobutanecarbonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 86770-80-1, category: nitriles-buliding-blocks

EXAMPLE 20 Preparation of 1-(3-chloropyridin-2-yl)-3,3-difluorocyclobutanecarbonitrile To a 100 mL round bottom flask was added 2,3-dichloropyridine (2.9 g, 20 mmol), 3,3-difluorocyclobutanecarbonitrile (2.1 g, 18 mmol), and toluene (50 mL). The mixture was cooled to C. and sodium hexamethyldisilazide (NaHMDS, 2.0 M in THF, 11 mL, 22 mmol) was added. The reaction mixture was warmed to rt and stirred for 2 h. The mixture was then diluted with EtOAc (20 mL) and water (20 mL). The aqueous layer was extracted with EtOAc and the combined organic phases were washed with brine, dried over Na2SO4, and concentrated to provide the desired product (3.4 g) as a colorless oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Cytokinetics, Inc.; Ashcraft, Luke W.; Bergnes, Gustave; Collibee, Scott; Chuang, Chihyuan; Gardina, Jeff; Morgan, Bradley P.; Muci, Alex R.; Qian, Xiangping; Romero, Antonio; Warrington, Jeffrey; Yang, Zhe; US9133123; (2015); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 86770-80-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 86770-80-1, name is 3,3-Difluorocyclobutanecarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

3 ,3-difluoro- 1 -(4-(trifluoromethyl)pyridin-2-yl)cyclobutanecarbonitrile [1270] Example 125B and 2-fluoro-4-(trifluoromethyl)pyridine (0.900 mL, 7.39 mmol) were dissolved in toluene (2.4 mL), cooled to <5 C and added KHMDS (29.6 mL, 14.78 mmol) dropwise, allowed to warm slowly to room temperature and stirred for 90 minutes. The mixture was diluted with MTBE and washed with water (2x). The organic phase was dried (Na2S04), filtered, and concentrated. The residue was chromatographed on silica gel (0-25% EtOAc/hexanes) to provide Example 125C (1.22 g, 4.65 mmol, 63.0 % yield). XH NMR (300 MHz, DMSO-d6) ? 9.00 - 8.94 (m, 1H), 8.04 - 7.99 (m, 1H), 7.88 (ddd, J= 5.1, 1.6, 0.8 Hz, 1H), 3.68 - 3.48 (m, 5H). In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,3-Difluorocyclobutanecarbonitrile, other downstream synthetic routes, hurry up and to see. Reference:
Patent; ABBVIE INC.; BAYBURT, Erol K.; CLAPHAM, Bruce; COX, Phil B.; DAANEN, Jerome F.; GOMTSYAN, Arthur; KORT, Michael E.; KYM, Philip R.; VOIGHT, Eric A.; SCHMIDT, Robert G.; DART, Michael J.; GFESSER, Gregory; WO2013/62964; (2013); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 86770-80-1, name is 3,3-Difluorocyclobutanecarbonitrile, molecular formula is C5H5F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 86770-80-1

A solution of 3,3-difluorocyclobutane-l-carbonitrile (1 g, 8.54 mmol) in ethanol (15 mL) was treated with hydroxylamine (50% in water) (5.25 mL, 86.0 mmol) and stirred at 80 C for 3 h. The reaction mixture was allowed to cool and then concentrated in vacuo. The residue was partitioned between DCM (10 mL) and water (10 mL). The organic phase was separated, the aqueous phase was extracted with DCM (3 x 5 mL),. The product re-extracted with 1 : 1 IPA/CHCI3 (3 x 60 mL), organic separated and dried over sodium sulfate and concentrated in vacuo to afford the title compound as an orange gum (545 mg,42%). 1H NMR (500 MHz, DMSO-d6) delta 9.07 (s, 1H), 5.44 (s, 2H), 2.84 – 2.59 (m, 5H). LCMS (ES+) RT 0.25 min, 151.0 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 86770-80-1, its application will become more common.

Reference:
Patent; UCB BIOPHARMA SPRL; ALEXANDER, Rikki, Peter; BRACE, Gareth, Neil; BROWN, Julien, Alistair; CALMIANO, Mark, Daniel; CHOVATIA, Praful, Tulshi; DELIGNY, Michael; GALLIMORE, Ellen, Olivia; HEER, Jag, Paul; JACKSON, Victoria, Elizabeth; KROEPLIEN, Boris; MAC COSS, Malcolm; QUINCEY, Joanna, Rachel; SABNIS, Yogesh, Anil; SWINNEN, Dominique, Louis, Leon; ZHU, Zhaoning; WO2015/86526; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 86770-80-1, name is 3,3-Difluorocyclobutanecarbonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 86770-80-1

Zinc metal (0.558 g, 10 micron dust, 8.5 mmol) was stirred in THF (2.5 ml) and methane sulphonic acid (0.04 mmol) was added and refluxed at 76 C. for 10 minutes. To this was added 3,3-difluoro-cyclobutanecarbonitrile (500 mg, 4.3 mmol, prepared according to Elend et al. Synth Comm, 2005, 35, 657) and the reaction mixture was heated for a further 10 minutes. Ethyl bromoacetate (0.751 ml, 6.8 mmol) dissolved in THF (0.5 mL) was then injected over a 2 hour period with the aid of a syringe pump and after the addition the mixture was stirred for a further 30 minutes. Aqueous HCl (3 ml of 3 M solution) was added drop-wise at 0 C. and the reaction mixture was then stirred for 17 hours between 0 and 20 C. The reaction mixture was analyzed by MS and TLC which showed the formation of the product and the consumption of the starting material and the reaction was worked up with (2×20 ml) water and (2×20 ml) ethyl acetate, the organic portion was then dried (Na2SO4) and reduced in vacuo. The product was isolated and purified using flash chromatography (AcOEt 7:93 heptane) and 3-(3,3-difluoro-cyclobutyl)-3-oxo-propionic acid ethyl ester (599 mg, 68% yield) was obtained as a colourless liquid. MS (ESI+): 207.1 ([M+H]+).

According to the analysis of related databases, 86770-80-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Amrein, Kurt; Hunziker, Daniel; Kuhn, Bernd; Mayweg, Alexander V.; Neidhart, Werner; US2007/49574; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 86770-80-1, name is 3,3-Difluorocyclobutanecarbonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 3,3-Difluorocyclobutanecarbonitrile

Borane-THF (1 M in THF, 16.20 mmol, 16.20 mL) was added drop-wise over 5 minutes to a solution of 3,3- difluorocyclobutanecarbonitrile (14.70 mmol, 1.72 g) in (0889) THF (5 mL) under N2. The resulting solution was then heated to reflux for 20 hours then cooled in an ice-water bath. Methanol (20 mL) was added drop-wise. The (0890) resulting mixture was concentrated under reduced (0891) pressure. The residue was dissolved in methanol (10 mL) and concentrated hydrochloric acid (10 mL) and heated at reflux for 2 hours. The mixture was concentrated under reduced pressure and the residue azeotroped twice with ethanol before being suspended in diethyl ether. The resulting cream solid was isolated by filtration and dried under suction to give the title compound as a white solid (1.48 g, 64%)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.