Category: 858523-37-2

Electric Literature of 858523-37-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 858523-37-2 name is (4-Bromo-2-methoxyphenyl)acetonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation 6(S)-3-(4-Bromo-2-hydroxy-phenyl)-pyrrolidine-l-carboxylic acid tert-bntyl ester The synthetic procedure described in this Preparation was carried out according to the process shown in Scheme G. EPO SCHEME GStep 1 (4-Bromo-2-methoxy-phenyl)-acetic acid; A solution of NaOH (5.72 g, 143 mmol) in water (29 mL) was added to a solution of (4- bromo-2-methoxy-phenyl)-acetonitrile (10.2 g, 45.1 mmol) in MeOH (100 mL). The reaction mixture was heated at reflux for 18 hours. The solvent was evaporated under reduced pressure and water was added. The aqueous mixture was washed with diethyl ether, and the aqueous layer was acidified by addition of aqueous HCl (2 M) to pH 1. The aqueous mixtuer was then extracted with EtOAc, and the combined organic extracts were washed with brine, dried OVCrNa2SO4, filtered, and evaporated under reduced pressure to give 9.49 g (86% yield) of (4-bromo-2-methoxy-phenyl)-acetic acid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (4-Bromo-2-methoxyphenyl)acetonitrile, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/55847; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts