Category: 79463-77-7

Electric Literature of 79463-77-7, The chemical industry reduces the impact on the environment during synthesis 79463-77-7, name is Diphenyl N-cyanocarbonimidate, I believe this compound will play a more active role in future production and life.

Diphenyl N-cyanocarbonimidate [79463-77-7] (200 mg, 0.81 mmol) and 3,4-dimethoxyaniline [6315- 89-5] (137 mg, 0.89 mmol) were dissolved in DCM (2 mL) and 2-propanol (2 mL) and DIPEA (159 mg, 1.22 mmol) were added and the reaction mixture was stirred at r.t. for ~1 h. The mixture was concentrated in vacuo and the residue was purified by flash column chromatography on silica (gradient elution with 15 – 100% EtOAc/hexane) to afford the title compound (198 mg, 82%) as a white solid. dH (300 MHz, DMSO -d6) 10.65 (s, 1H), 7.51 – 7.37 (m, 2H), 7.36 – 7.22 (m, 3H), 7.09 (d, J 1.8 Hz, 1H), 7.03 – 6.91 (m, 2H), 3.75 (s, 6H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diphenyl N-cyanocarbonimidate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UCB BIOPHARMA SRL; CHOVATIA, Prafulkumar Tulshibhai; CONNELLY, Rickki Lee; FRANKLIN, Richard Jeremy; HASLETT, Gregory William; HENRY, Alistair James; MADDEN, James; NEUSS, Judi Charlotte; NORMAN, Timothy John; PHILPS, Oliver; PITT, William Ross; RAMPALAKOS, Konstantinos; SELBY, Matthew Duncan; SELVARATNAM, Suganthan; TRANI, Giancarlo; ZHU, Zhaoning; (768 pag.)WO2019/243550; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 79463-77-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 79463-77-7, name is Diphenyl N-cyanocarbonimidate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Example 1-177 [(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-amino]-morpholin-4-yl-methylene-cyanamide To a stirred solution of 3-(aminomethyl)-7-chloro- l-phenylquinolin-4(lH)-one(intermediate D) (30 mg, 0.105 mmol) and N,N-diisopropylethylamine (40.9 mg, 55.2 muL·, 0.316 mmol) in NuMuRho (0.5 mL) was added diphenyl-cyanocarbonimidate (25.1 mg, 0.105 mmol). After 1 hr., morpholine (11.9 mg, 12.0 mu?^, 0.137 mmol) was added and the mixture was warmed to 120 I in a sealed microwave tube. After lhr., LCMS showed complete conversion to product. The mixture was allowed to cool to room temp, and the crude product was purified using preparative reverse-phase HPLC. The product [(7- chloro-4-oxo- 1 -phenyl- 1 ,4-dihydro-quinolin-3ylmethyl)-amino]-morpholin-4-yl- methylene-cyan- amide (25 mg, 56%) was obtained as a white solid. 1H NMR (400 MHz, DMSO-cfo) 6 ppm 8.26 (d, 7=8.8 Hz, 1 H) 8.07 (s, 1 H) 7.61 – 7.76 (m, 3 H) 7.57 – 7.62 (m, 2 H) 7.48 – 7.53 (m, 1 H) 7.46 (dd, .7=8.8, 1.9 Hz, 1 H) 6.93 (d, 7=1.9 Hz, 1 H) 4.36 (d, 7=4.8 Hz, 2 H) 3.51 – 3.62 (m, 4 H) 3.35 – 3.46 (m, 4 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diphenyl N-cyanocarbonimidate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BILOTTA, Joseph Anthony; CHEUNG, Adrian Wai-Hing; FIROOZNIA, Fariborz; GUERTIN, Kevin Richard; HAYDEN, Stuart; HAYNES, Nancy-Ellen; LUKACS-LESBURG, Christine M.; MARCOPULOS, Nicholas; MERTZ, Eric; QI, Lida; QIAN, Yimin; SO, Sung-Sau; TAN, Jenny; THAKKAR, Kshitij Chhabilbhai; WO2013/7676; (2013); A1;,
Nitrile – Wikipedia,
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These common heterocyclic compound, 79463-77-7, name is Diphenyl N-cyanocarbonimidate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Diphenyl N-cyanocarbonimidate

a) A solution of (+-)-6-(cyclopentyloxy)-5-methoxy-beta-methyl-2-pyridineethanamine (0.037 mol) and diphenyl N-cyanocarbonimidate (0.037 mol) in ethanol (100 ml) was stirred for one day at RT. The precipitate was filtered off, washed with ethanol, DIPE, then dried, yielding 9 g (61.7%) of (+-)-phenyl N’-cyano-N-[2-[6-(cyclopentyloxy)-5-methoxy-2-pyridinyl]propyl]carbamimidate(interm. 9). The filtrate was evaporated under reduced pressure. The residue was dissolved in CH2Cl2. The organic solution was washed three times with 2 N NaOH. The organic layer was separated, dried, filtered and the solvent was evaporated, yielding 4.1 g of intermediate (9). Total yield is 89%.

The synthetic route of Diphenyl N-cyanocarbonimidate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Janssen Pharmaceutica N.V.; US6656959; (2003); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 79463-77-7, name is Diphenyl N-cyanocarbonimidate, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 79463-77-7, Product Details of 79463-77-7

DIPEA (1.52 mL, 8.82 mmol) then diphenyl cyanocarbonimidate (1.08 g, 4.41 mmol) in DCM (11 mL) were added to a sol. of intermediate 12 (1 g, 4.41 mmol) in DCM (39 mL). The r.m. was stirred at r.t. for 1 h. The solvent was evaporated. Yield: 0.5 g of intermediate 13 (34 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diphenyl N-cyanocarbonimidate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICALS, INC.; BISCHOFF, Francois, Paul; VELTER, Adriana, Ingrid; VAN BRANDT, Sven, Franciscus, Anna; BERTHELOT, Didier, Jean-Claude; WO2012/126984; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 79463-77-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 79463-77-7, name is Diphenyl N-cyanocarbonimidate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 343; 1-(1-{2-[4-(Benzothiazol-2-yloxy)-phenyl]-ethyl}-piperazine-4-yl)-3-cyano-2- phenyl-isourea; The 1- {2- [4- (BENZOTHIAZOL-2-YLOXY)-PHENYL]-ETHYL}-PIPERIDIN-4-YLAMINE hydrochloride was prepared from (1- {2- [4- (BENZOTHIAZOL-2-YLOXY)-PHENYL]-ETHYL}- piperidin-4-yl)-carbamic acid tert-butyl ester EXAMPLE 337 by removal of the Boc group according to EXAMPLE 266, step B. The free base was prepared by suspending 1- {2- [4- (BENZOTHIAZOL-2-YLOXY)-PHENYL]-ETHYL}-PIPERIDIN-4-YLAMINE hydrochloride (1.3 g, 3.3 MMOL) in CH2CI2 (20 mL) and washing with a solution of saturated NaHCO3 (20 mL). The organic layer was dried over NA2SO4, filtered and concentrated under reduced pressure to give 1.0 g (83% yield) of 1- {2- [4- (BENZOTHIAZOL-2-YLOXY)-PHENYL]-ETHYL}-PIPERIDIN-4-YLAMINE free base. A solution of 1- {2- [4- (BENZOTHIAZOL-2-YLOXY)-PHENYL]-ETHYL}-PIPERIDIN-4-YL AMINE (145 mg, 0.4 MMOL) in ethanol (5 mL) was treated with diphenyl cyanocarbodiimidate (319 mg. 1.34 MMOL) and heated to 80 C for 16h. The reaction was concentrated under reduced pressure and purified on Si02 (12 g, 0-10% [2 M NH3 CH30H]/CH2CI2) to give of the title compound (173 mg, 85% yield). MS (ESI) : exact mass calculated FOR C28H27N502S1, 496.2 ; m/z found, 498.4 [M+H].. H NMR (400 MHz, CDC13) : 7.73 (d, J = 8.7, 1 H), 7.66 (dd, J = 7.9, 0.7, 1 H), 7.45-7. 36 (m, 4H), 7.31-7. 24 (m, 5H), 7.08 (d, J = 7.8, 2H), 6.36 (br d, J = 6.5, 1 H), 3. 87-3. 76 (m, 1 H), 3.02 (br d, J = 11. 2, 2H), 2.83 (dd, J = 8.4, 7.3, 2H), 2.64 (DD, J = 8. 6,5. 4, 2H), 2.21 (t, J = 11. 1, 2H), 2.07 (d, J = 11.0, 2H), 1.76 (dd, J = 20.7, 10.4, 2H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diphenyl N-cyanocarbonimidate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2005/12296; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 79463-77-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 79463-77-7 as follows.

A mixture of 3-aminobenzotrifluoride (15 g, 93 mmol) and diphenyl cyanocarbon-imidate (22.2 g, 93 mmol) was heated at reflux in THF (100 ml) for 20 h. The r.m. was then concentrated under reduced pressure. H2O was then added and the resulting solid was filtered and dried in vacuo, yielding 20.7 g of intermediate 35 (72%).

According to the analysis of related databases, 79463-77-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Van Brandt, Sven Franciscus Anna; De Cleyn, Michel Anna Jozef; Gijsen, Henricus Jacobus Maria; Berthelot, Didier Jean-Claude; Surkyn, Michel; US2012/295891; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 79463-77-7, name is Diphenyl N-cyanocarbonimidate, This compound has unique chemical properties. The synthetic route is as follows., Formula: C14H10N2O2

To a stirred solution of intermediate 11 (0.5g, 1.996 mmol) and diphenyl cyanocarbonimidate (0.475 g, 1.996 mmol) in acetonitrile (30 mL) was added triethylamine (0.0.833 mL, 5.988 mmol) at RT and stirred for l6h at RT. After completion of reaction, the reaction mixture was concentrated under reduced pressure. The residue obtained was purified by combiflash column on silica gel (hexanes/ethyl acetate=75/25) to give the title compound (0.5 g, 70%). LCMS: m/z 358.2 [M]+

According to the analysis of related databases, 79463-77-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; CHIKKANNA, Dinesh; KHAIRNAR, Vinayak V.; RAMACHANDRA, Muralidhara; SATYAM, Leena Khare; (139 pag.)WO2019/142126; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 79463-77-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 79463-77-7, name is Diphenyl N-cyanocarbonimidate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

6.6. Example 6(S)-N-(3-chlorophenyl)-N’-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide A. Preparation of phenyl N-3-chlorophenyl-N’-cyanocarbamimidate. Diphenyl-N-cyanocarbonimidate (2 g, 8.4 mmol) and 3-chloroaniline (0.88 ml, 8.4 mmol) were added to acetonitrile (20 ml). The solution was heated at 50 C. overnight and cooled to room temperature, resulting in precipitation of the product. The white crystalline solid was filtered to give phenyl N-3-chlorophenyl-N’-cyanocarbamimidate (2 g, 7.3 mmol, 88%).1H NMR (400 MHz, chloroform-d) delta ppm 7.42-7.48 (m, 3H), 7.28-7.36 (m, 2H), 7.24-7.27 (m, 2H), 7.13-7.18 (m, 2H); MS (ES+) [M+H]+=272.

The synthetic route of Diphenyl N-cyanocarbonimidate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Harrison, Bryce Alden; Kimball, Spencer David; Mabon, Ross; Rawlins, David Brent; Rice, Dennis S.; Voronkov, Michael Victor; Zhang, Yulian; US2009/42893; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 79463-77-7 as follows. Safety of Diphenyl N-cyanocarbonimidate

A mixture of 4-(4-amino-2,6-dimethoxy-phenoxy)-piperidine-1-carboxylic acid benzyl ester (57.8 mg, 0.180 mmol) and diphenyl cyanocarbonimide (42.8 mg, 0.180 mmol) in toluene (1.0 mL) was heated at 100 C overnight. The mixture was concentrated and purified by silica gel column chromatograghy eluted with EtOAc:hexanes (40 to 60% EtOAc) to give the title compound (65.3 mg, 82%) as a colorless oil. MS (ES+): m/z = 531.2.

According to the analysis of related databases, 79463-77-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2004/46120; (2004); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 79463-77-7, name is Diphenyl N-cyanocarbonimidate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 79463-77-7

A mixture of 3,4,5-trimethoxyaniline (1.83 g, 10 mmol) and diphenyl-cyanocarbon-imidate (2.62 g, 11 mmol) in iso-propanol (30 mL) was stirred at 100-1l0oC for 1h. The reaction was cooled and filtered, washing with ether to provide the title compound (2.79 g, 85% yield) as a white solid. 1H-NMR (500 MHz, DMSO-d6) 10.8 (s, 1H), 7.45 (t, 2H), 7.31 (m, 3H), 6.83 (s, 2H), 3.76 (s, 6H), 3.65 (s, 3H) ppm; MS (FIA) 328.1 (M+H); HPLC (method A) 3.211 min.

The synthetic route of 79463-77-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2004/46120; (2004); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts