Reference of 778-94-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 778-94-9, name is 2-Nitro-4-(trifluoromethyl)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step 2. Synthesis of intermediate Compound 3To a solution of SnCl2 (3.34 g, 14.8 mmol) in concentrated HC1 (2.7 mL) was added a solution of compound 2 (0.8 g, 3.7 mmol) in 95% ethanol (1.3 mL). The resulting mixture was stirred at room temperature for 2 h. TLC showed the reaction was completed, and the mixture was treated with 50% aqueous NaOH solution (10 mL) to give the yellow solid. The resulting mixture was filtered, and the filter cake was dissolved in CH2C12 (200 mL). The mixture was filtered, and the filtrate was dried over Na2S04 and concentrated in vacuo to give compound 3 (0.4 g, 58%>) as a yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Nitro-4-(trifluoromethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DILLARD, Lawrence W.; YUAN, Jing; LEFTHERIS, Katerina; VENKATRAMAN, Shankar; WU, Guosheng; JIA, Lanqi; XU, Zhenrong; CACATIAN, Salvacion; MORALES-RAMOS, Angel; SINGH, Suresh; ZHENG, Yajun; WO2011/106414; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts