Category: 77668-42-9

Application of 77668-42-9, A common heterocyclic compound, 77668-42-9, name is 2,3-Dichlorobenzoyl cyanide, molecular formula is C8H3Cl2NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

400 g (2 moles) of 2,3-dichlorobenzoyl cyanide are added to a mixture prepared from 333.6 g (2.45 moles) of aminoguanidine bicarbonate in 800 mL of methanesulphonic acid. The mixture is then heated at 45C for 5 hours, cooled to 10C and 2.4 L of water is added slowly, controlling exothermy at 20-30C. The mixture is then adjusted to pH 11 with a 50% NAOH solution, filtered, the solid washed with water and dried at 45C to yield 419.8 g (82%) of the product of the title. NMR 1H (DMSO), delta (ppm): 6. 5- 6. 9 (s, 4H,-N=C (NH2) 2), 7.4 (t, 1H, ARH), 7. 6 (d, 2H, ArH). M. p. = 180-183C.

The synthetic route of 77668-42-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LABORATORIOS VITA, S.A.; WO2004/39767; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 77668-42-9, A common heterocyclic compound, 77668-42-9, name is 2,3-Dichlorobenzoyl cyanide, molecular formula is C8H3Cl2NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the reactor was added 40g aminoguanidine carbonate and 200ml of methanol (entrainer)30g concentrated sulfuric acid was added dropwise with stirring, the addition was completed dropwise distillation entrainer,And bring out the water, suction filtration,Solid into the reaction flask, at 80 C under reduced pressure and drained.Adding 2,3-dichlorobenzoyl cyanide solution obtained in step (1), heating to 80 C., reacting for 3 h to the end of the reaction, lowering to room temperature, and filtering by suction to obtain white sand particles;

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Zhejiang Qicai Environment Technology Co., Ltd.; Jin Cheng; Chen Lina; Liang Wei; Zhang Tong; Chen Lei; (6 pag.)CN106083753; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 77668-42-9, These common heterocyclic compound, 77668-42-9, name is 2,3-Dichlorobenzoyl cyanide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5. Synthesis of lamotrigine via the tetrafluoroborate saltA solution of aminoguanidinium tetrafluoroborate was freshly prepared from aminoguani- dinium bicarbonate (2.42 g, 17.8 mmol) and anhydrous tetrafluoroboric acid, 53% (v/v) in diethylether (6.18 g), and diluted with acetonitrile (8 mL). 2,3-dichlorobenzoyl cyanide (1.50 g, 7.50 mmol) was added and the reaction mixture was heated to 45 C for 4 hours.In analogy to example 2 the reaction mixture was poured into ice water, yielding the tetrafluoroborate salt of compound II as a suspension which was cooled down to 10 C and filtrated. The filter cake was directly dissolved from the filter at room temperature using essentially pure acetonitrile without any additional solvent. The subsequent cyclization step was performed as described in example 2.

Statistics shows that 2,3-Dichlorobenzoyl cyanide is playing an increasingly important role. we look forward to future research findings about 77668-42-9.

Reference:
Patent; LONZA AG; WO2008/19798; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 77668-42-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 77668-42-9 name is 2,3-Dichlorobenzoyl cyanide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

6. Synthesis of lamotrigine via the tetrafluoroborate salt as a one-pot reactionThe condensation step was performed as described in example 5, with the exception that the isolation of the tetrafluoroborate intermediate was omitted. After the condensation step the solvents were removed on a rotary evaporator, then an equal volume of acetonitrile was added and the subsequent cyclization step was performed as described in example 2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3-Dichlorobenzoyl cyanide, and friends who are interested can also refer to it.

Reference:
Patent; LONZA AG; WO2008/19798; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts