Application of 77532-78-6, The chemical industry reduces the impact on the environment during synthesis 77532-78-6, name is 2-Bromo-6-methylbenzonitrile, I believe this compound will play a more active role in future production and life.
A. N-Butyl-2,3-difluoro-N-[1-(2-piperidin-1-ylmethyl-benzyl)-1H-benzoimidazol-2-ylmethyl]-benzamide A solution of 35 g (0.18 mole) of cyanobromotoluene and 16.18 g (0.19 mole) of piperidine in 300 mL of anhydrous DMF was treated with 73 g (0.5 mole) of K2CO3 at 50 C. for 2 hr. The reaction mixture was filtered through a plug of Celite, washed with 400 mL of ethyl acetate, and the filtrate was partitioned between ethyl acetate and 1/2 saturated brine. The organic layer was dried over anhydrous Na2SO4 and concentrated in vacuo, yielding 36 g (0.18 mole) 100% of 2-Piperidin-1-ylmethyl-benzonitrile. 1H NMR (300 MHz, CDCl3) 7.6 (m, 3H), 7.24 (m, 1H), 3.6 (s, 2H), 2.4 (m, 4H), 1.5 (m, 6H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-6-methylbenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DeSimone, Robert W.; Peterson, John; Steenstra, Cheryl; Shen, Yiping; Gustavson, Linda; Bakthavatchalam, Rajagopal; Hutchison, Alan; US2003/216390; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts