Reference of 77326-62-6, The chemical industry reduces the impact on the environment during synthesis 77326-62-6, name is 2-Amino-6-bromobenzonitrile, I believe this compound will play a more active role in future production and life.
1.85 g of concentrated hydrochloric acid are slowly added to a a suspension of 1 g of of 2- amino-6-bromo-benzonitrile in 11 ml of glacial acetic acid at room temperature under stirring. Further 10 ml of glacial acetic acid are added and the mixture was heated to 800C. Then the mixture is cooled down to 100C and a solution of 0.37 g of sodium nitrite in 1.7 ml of water is added within 2 minutes. The reaction mixture is stirred 2 hours at room temperature in order to obtain the diazonium salt. In a separate flask a saturated solution of sulfur dioxide in 20 ml of glacial acetic acid is treated at room temperature with a solution of 0.4 g of copper(ll) chloride in 1 ml of water. Then the mixture of with the diazonium salt is added and the reaction mixture is stirred for 1 hour at room temperature.The reaction mixture is poured into ice cooled water. The aqueous layer is extracted three times with dichloromethane. The combined organic layers are dried over magnesium sulfate, filtered and concentrated in vacuo. The resulting red residue is suspended in cyclohexane and filtered. The resulting residue is washed with cyclohexane and dried to afford 1 g of 3-bromo-2- cyano-benzenesulfonyl chloride.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-6-bromobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2009/87085; (2009); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts