Electric Literature of 76574-39-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 76574-39-5, name is 2-(2-Bromo-6-chlorophenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
2-(2-Bromo-.6-chlorophenyl)acetonitrile (450 mg, 2.0 mmol) (43-1), 3- pyridylboronic acid (251 mg, 2.1 mmol) (43-2), potassium fluoride (230 mg, 3.9 inmol), 1,4- dioxane (12 mL), methanol (3.6 rnL), Pd2(dba)3 (71 rng, 0.080 mrnol) and dicyciohexyl-12-(2,6- dimethoxyphenyl)phenyi]phosphane (32 Ing, 0.080 mmol) were combined under an atmosphere of nitrogen and the resulting mixture was heated at 80 C After 16 h, the reaction was filtered and concentrated under reduced pressure. The resulting oil was dissolved in DCM and purified by silica gel chromatography eluting with methanol/dichloromethane to afford 317 mg (71%) 2- [2.-chloro-6-(-pyridyl)phenyllacetonitriie (43-3). LCMS (ESI): [M+Hf = 229.1
The synthetic route of 2-(2-Bromo-6-chlorophenyl)acetonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ACHAOGEN, INC.; COHEN, Frederick; KANE, Timothy Robert; DOZZO, Paola; HILDEBRANDT, Darin James; LINSELL, Martin Sheringham; MACHAJEWSKI, Timothy D.; MCENROE, Glenn A.; (172 pag.)WO2018/23081; (2018); A1;,
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