Category: 75629-62-8

On November 29, 1984, Aariin, Kei Masaa; Piitaa, Maachin Koerushu published a patent.Formula: C12H7N3 The title of the patent was Optical filters for photoimaging materials. And the patent contained the following:

Optical filters contain 鈮? dye(s) selected from benzylidene and naphthalimide dyes and a binder composition containing phenol-formaldehyde resin in amount sufficient to cause optical shift in the absorption spectra of the dye(s). The filters are especially useful for UV- and visible light-sensitive photoimaging systems, and especially useful as photog. halation inhibiting layers. Thus, Disperse Yellow 31 60, Butvar B-76 (a butyral resin) 108, Resinox RS 7280 (a phenolic resin) modified with DD1-1410 (a diisocyanate compound) 1440 and MeCOEt 1720 g were mixed to give a halation inhibitor coating composition The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Formula: C12H7N3

The Article related to halation inhibitor photog benzylidene dye, naphthalimide dye photog halation inhibitor, binder photog halation inhibiting layer, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Silver Halide Photographic Chemistry and Processes and other aspects.Formula: C12H7N3

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Badiger, Krishnappa B.; Kamanna, Kantharaju published an article in 2021, the title of the article was Knoevenagel condensation reaction catalysed by agro-waste extract as a greener solvent catalyst.Name: 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

This paper present a novel Knoevenagel reaction protocol for the condensation of aromatic/heteroaromatic aldehydes RCHO (R = 2-phenylethenyl, naphthalen-1-yl, furan-2-yl, 1H-indol-3-yl, etc.) with malononitrile to give 伪, 尾-unsaturated benzylidene derivs RCH=C(CN)2. The main focus of this work is to reveal the usability of agro-waste extracts as a catalyst in the Knoevenagel condensation. In addition, the present method describes direct isolation of the formed products without using organic solvent extraction and gives good yields product. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Name: 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to unsaturated benzylidene preparation green chem, aryl aldehyde malononitrile knoevenagel condensation agro waste extract catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Name: 2-((1H-Indol-3-yl)methylene)malononitrile

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On January 31, 2022, Chakraborty, Sourav; Rudra Paul, Abhijit; Majumdar, Swapan published an article.Name: 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Base and metal free true recyclable medium for Knoevenagel condensation reaction in SDS-ionic liquid-aqueous miceller composite system. And the article contained the following:

This paper presents for the first time a base and metal free procedure for Knoevenagel condensation reaction in a neutral medium comprises water-SDS-imidazolium ionic liquid composite system. Knoevenagel condensation products from the different aromatic aldehydes and active methylene compounds such as malononitrile, Et cyanoacetate or cyano acetic acid provides good to excellent yields in all cases examined at 80掳C. The developed protocol has several advantages such as chromatog. and organic volatile solvent free protocol, short reaction time and recyclability of catalyst including reaction waste. The reaction is believed to proceed in the hydrophobic cavity of the micelle formed in the medium which was proved by dynamic light scattering studies. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Name: 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to aryl aldehyde active methylene compound knoevenagel condensation green chem, sds ionic liquid aqueous miceller composite system, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Name: 2-((1H-Indol-3-yl)methylene)malononitrile

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Magar, Rupali L.; Thorat, Prashant B.; Waware, Jagdish L.; More, Rameshwar R.; Solanke, Usha A.; Patil, Bhagwan R.; Pawar, Rajendra P. published an article in 2015, the title of the article was Synthesis of Some Novel 3-Substituted Indole Derivatives Using Polyamine Functionalized Heterogeneous Catalyst.Recommanded Product: 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

In present work, we have described the use of polyamine solid supported GN3 as catalyst in organic transformations using 1H-indole-3-carbaldehyde. To the best of our knowledge, reports for the synthesis of chromene substituted at 3C position of indole are extremely rare in the literature. The polyamine functionalized immobilized silica (GN3) was found to be an excellent catalyst for synthesis of novel 2-amino-4-(1H-indol-3-yl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile derivatives and Knoevenagel condensation. Catalyst GN3 was able to furnish excellent yield for a wide range of products. Moreover, the catalyst was reusable and reused for several times without loss of its catalytic activity. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Recommanded Product: 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to indole preparation gn3 reusability catalyst mechanism nucleophile condensation reaction, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Recommanded Product: 2-((1H-Indol-3-yl)methylene)malononitrile

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Jain, S.; Reddy, B. N.; Rao, K. S. published an article in 2012, the title of the article was Synthesis of biheterocycles containing indole nucleus and their antibacterial activity.Computed Properties of 75629-62-8 And the article contains the following content:

Indole-3-carboxaldehydes underwent condensation with Et cyanoacetate and malononitrile to give the acrylonitrile which on reaction with hydrazine hydrate yield 3,5-diamino-5-hydroxy-4-(3-indolylmethylene)pyrazoles and 3-amino-5-hydroxy-4-(3-indolylmethylene)pyrazoles, resp. The new compounds were also screened for their antibacterial activity. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Computed Properties of 75629-62-8

The Article related to indole carboxaldehyde malononitrile cyanoacetate condensation, indolyl acrylonitrile preparation antibacterial hydrazine cyclocondensation, indolylidene aminopyrazole preparation antibacterial and other aspects.Computed Properties of 75629-62-8

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On March 31, 2020, Silva, Daniel; Mendes, Eduarda; Summers, Eleanor J.; Neca, Ana; Jacinto, Ana C.; Reis, Telma; Agostinho, Paula; Bolea, Irene; Jimeno, M. Luisa; Mateus, M. Luisa; Oliveira-Campos, Ana M. F.; Unzeta, Mercedes; Marco-Contelles, Jose; Majekova, Magdalena; Ramsay, Rona R.; Carreiras, M. Carmo published an article.Computed Properties of 75629-62-8 The title of the article was Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents. And the article contained the following:

Based on the monoamine oxidase (MAO) inhibition properties of aminoheterocycles with a carbonitrile group we have carried out a systematic exploration to discover new classes of carbonitriles endowed with dual MAO and AChE inhibitory activities, and Aβ anti-aggregating properties. Eighty-three nitrile-containing compounds, 13 of which are new, were synthesized and evaluated. In vitro screening revealed that 31, a new compound, presented the best lead for trifunctional inhibition against MAO A (0.34μM), MAO B (0.26μM), and AChE (52μM), while 32 exhibited a lead for selective MAO A (0.12μM) inhibition coupled to AChE (48μM) inhibition. Computational anal. revealed that the malononitrile group can find an advantageous position with the aromatic cleft and FAD of MAO A or MAO B. However, the total binding energy can be handicapped by an internal penalty caused by twisting of the ligand mol. and subsequent disruption of the conjugation (32 in MAO B compared to the conjugated 31). Conjugation is also important for AChE as well as the hydrophilic character of malononitrile that allows this group to be in close contact with the aqueous environment as seen for 83. Although the effect of 31 and 32 against Aβ1-42, was very weak, the effect of 63 and 65, and of the new compound 75, indicated that these compounds were able to disaggregate Aβ1-42 fibrils. The most effective was 63, a (phenylhydrazinylidene)propanedinitrile derivative that also inhibited MAO A (1.65μM), making it a potential lead for Alzheimer’s disease application. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Computed Properties of 75629-62-8

The Article related to nitrile compound acetylcholinesterase monoamine oxidase alzheimer agent biol evaluation, ache inhibitors, alzheimer’s disease, aβ1-42 disaggregating agents, mao inhibitors, in silico study, nitrile-containing compounds and other aspects.Computed Properties of 75629-62-8

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Ang, Wei Jie; Chng, Yong Sheng; Lam, Yulin published an article in 2015, the title of the article was Fluorous bispidine: a bifunctional reagent for copper-catalyzed oxidation and Knoevenagel condensation reactions in water.Product Details of 75629-62-8 And the article contains the following content:

Fluorous bispidine-type ligands, I [R = 4-CF3(CF2)7(CH2)3C6H4CH2, (CH2)2(CF2)7CF3] and II [R1 = (CH2)2(CF2)7CF3] has been developed to facilitate its recovery and reusability and to demonstrate its bifunctional property as a ligand and base in copper-catalyzed aerobic oxidation, the Knoevenagel condensation and tandem oxidation/Knoevenagel condensation in water under mild conditions. Application of the fluorous ligand was also extended to the surfactant-free copper-catalyzed allylic and benzylic sp3 C-H oxidation reaction in water. The fluorous ligands could be recovered using F-SPE with recovery ranging from 91-97% and could be reused five times with little loss of activity. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Product Details of 75629-62-8

The Article related to bispidine fluorous preparation, carbonyl compound preparation green chem, alc aerobic oxidation copper catalyst fluorous bispidine, alkene preparation green chem, active methylene carbonyl compound knoevenagel condensation copper fluorous bispidine and other aspects.Product Details of 75629-62-8

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On December 31, 2014, Dyachenko, I. V.; Ramazanova, E. Yu.; Dyachenko, V. D. published an article.Category: nitriles-buliding-blocks The title of the article was Synthesis of 4-methylmorpholinium 6-amino-3,5-dicyano-4-(furan-2-yl)pyridine-2-thio(seleno)lates and 3-[aryl(hetaryl)]-2-cyanoprop-2-enethioamides by michael reaction. And the article contained the following:

Michael reaction of di-Me (furan-2-ylmethylidene)malonate with 2-cyanoethanethio(seleno)amides and 4-methylmorpholine afforded 4-methylmorpholinium 6-amino-3,5-dicyano-4-(furan-2-yl)pyridine-2-thio(seleno)lates (I.4-methylmorpholinium; X = S, Se) via exchange of the CH acid components. Aryl(hetaryl)methylidenemalononitriles II reacted with cyanoethanethioamide under analogous conditions to give 3-aryl(hetaryl)-2-cyanoprop-2-enethioamides III which were converted into 3-aryl(hetaryl)-2-(1,3-thiazol-2-yl)prop-2-enenitriles (IV) according to Hantzsch (using BrCH2COR’, R’ = e.g., Ph). The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Category: nitriles-buliding-blocks

The Article related to michael carbon acid exchange furanylmethylenemalonate arylmethylenemalononitrile cyanoethanethioamide cyanoethaneselenoamide, pyridinethiolate aminocyanofuranyl, pyridineselenolate aminocyanofuranyl, hantzsch thiazole synthesis arylcyanopropenethioamide and other aspects.Category: nitriles-buliding-blocks

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On May 24, 1996, Gazit, Aviv; App, Harald; McMahon, Gerald; Chen, Jefferey; Levitzki, Alexander; Bohmer, Frank D. published an article.HPLC of Formula: 75629-62-8 The title of the article was Tyrphostins. 5. Potent Inhibitors of Platelet-Derived Growth Factor Receptor Tyrosine Kinase: Structure-Activity Relationships in Quinoxalines, Quinolines, and Indole Tyrphostins. And the article contained the following:

A series of 3-indoleacrylonitrile tyrphostins, 2-chloro-3-phenylquinolines, and 3-arylquinoxalines were prepared and tested for inhibition of platelet-derived growth factor receptor tyrosine kinase (PDGF-RTK) activity. The potency of the inhibitors was quinoxalines >quinolines >indoles. Lipophilic groups (Me, methoxy) in the 6 and 7 positions and Ph at the 3 position of quinoxalines and quinolines were essential for potency, in contrast to the hydrophilic catechol group in tyrphostins active against EGFR kinase inhibition at different sites. The inhibitors showed selectivity for PDGF and were not active against EGF receptor and HER-2/c-ErbB-2 receptor. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).HPLC of Formula: 75629-62-8

The Article related to quinoxaline tyrosine kinase inhibitor preparation structure, platelet growth factor receptor kinase preparation, quinoline tyrosine kinase inhibitor preparation structure, indole tyrphostin tyrosine kinase inhibitor preparation, msbar tyrosine kinase inhibitor tyrphostin and other aspects.HPLC of Formula: 75629-62-8

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On September 14, 2022, Mannarsamy, Maruthupandi; Nandeshwar, Muneshwar; Muduli, Gopendra; Prabusankar, Ganesan published an article.Application of 75629-62-8 The title of the article was Highly Active Cyclic Zinc(II) Thione Catalyst for C-C and C-N Bond Formation Reactions. And the article contained the following:

The first discrete seven-membered cyclic zinc(II) complex catalyzed room temperature Knoevenagel condensation reactions, and the synthesis of perimidine derivatives is reported under mild reaction conditions. The cyclic zinc(II) complex [(L)ZnBr2] (1) was isolated from the reaction between 1-(2-hydroxyethyl)-3-isopropyl-benzimidazol-2-thione (L, 2) and ZnBr2 (3). Complex 1 was characterized by different analytic techniques such as FTIR, CHNS, TGA, NMR, and SCXRD. The mononuclear zinc(II) complex 1 was used as a catalyst for Knoevenagel condensation reactions to isolate twenty different substituted methylene malononitriles with excellent yield. Besides, the zinc(II) thione complex 1 was used for the synthesis of 2,4-dihydroperimidine derivatives in a highly efficient manner. Catalyst 1 depicted wide substrate scopes. Overall, twenty different substituted methylene malononitriles and nine different perimidine derivatives were synthesized using catalyst 1 at room temperature The present study features a mild and fast synthetic approach along with excellent functional group tolerance. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Application of 75629-62-8

The Article related to preparation cyclic zinc hydroxyethylisopropylbenzimidazolthione coordination complex, crystal structure cyclic zinc hydroxyethylisopropylbenzimidazolthione coordination complex, thermal decomposition cyclic zinc hydroxyethylisopropylbenzimidazolthione coordination complex, knoevenagel condensation catalyst cyclic zinc hydroxyethylisopropylbenzimidazolthione coordination complex and other aspects.Application of 75629-62-8

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