Category: 75629-62-8

Siddegowda, K. Somashekarappa; Zabiulla, K. Mohammed; Yellappa, Shivaraj published an article in 2016, the title of the article was Synthesis of new potential indole-3-yl derivatives via Knoevenagel condensation.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

Knoevenagel reaction between indole-3-carboxaldehyde and active methylene or non-active methylene compounds RCH2R1 [R = CN, NO2, C(O)OCH2CH3, C(O)OCH3; R1 = CN, H, C(O)OCH2CH3, C(O)OCH3] yielded the corresponding condensation product, indole-3-yl derivatives I (R2 = H) and then their N-acetylation with acetyl chloride afforded N-acetyl-1H-indol-3-yl derivatives I [R2 = CH3C(O)]. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to indolylcarboxaldehyde methylene compound knoevenagel, indolyl methylene preparation acetyl chloride acylation, acetyl indolyl methylene preparation green chem, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yuan, Chang; Tan, Hao; Jiang, Xue-Fei; Liu, Si; Jiang, Lu; Cao, Qi-Ying; Xu, Xing-Jie; Deng, Xiao-Yan; Pan, Guan-Nan; Chen, Jian-Yang; Cui, Hai-Lei published an article in 2019, the title of the article was Phosphine-Catalyzed [3+2] Cycloaddition and Vinylation of Indole-Derived 伪,伪-Dicyanoolefins with 纬-Substituted Allenoates.COA of Formula: C12H7N3 And the article contains the following content:

A phosphine-catalyzed [3+2] cycloaddition of 纬-substituted allenoates RCH=C=CHR1 (R = H, Ph, 4-chlorophenyl, (CH2)4CH3; R1 = C(O)OCH2C6H5, C(O)OMe, C(O)OEt) with 伪,伪-dicyanoolefins I (R2 = SO2C6H5, tosyl, CH2C6H5, etc.; R3 = H, 5-Br, 5-MeO, 6-Cl) has been established, affording indole-incorporated highly functionalized cyclopentenes II. In addition, the vinylated indole-derived 伪,伪-dicyanoolefins III (R4 = Ph, 4-chlorophenyl, phenethyl) have also been realized under the same reaction conditions by switching to indole-derived 伪,伪-dicyanoolefins without protective group at N-1 position I (R2 = H). The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).COA of Formula: C12H7N3

The Article related to indole dicyanoolefin preparation regioselective diastereoselective enantioselective, dicyanoolefin allenoate cycloaddition reaction phosphine catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C12H7N3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 30, 1980, Moriya, Tamon; Hagio, Katsuaki; Yoneda, Naoto published an article.Application of 75629-62-8 The title of the article was Preparation and reactions of 3-(aminomethylene)-3H-indoles. And the article contained the following:

3-(Aminomethylene)-3H-indoles I (R = H, 5-OMe, 6-Me, 6-Cl; NR1R2 = pyrrolidino, piperidino, morpholino, NEt2, NBu2, NMe2) were prepared by the condensation of 3-indolecarboxaldehydes with secondary amines. Some were obtained as stable colorless prisms, while 3-(piperidinomethylene)-3H-indole and 3-(morpholinomethylene)-3H-indole readily polymerized in refluxing benzene. Reaction of I with electrophiles, such as alkyl and acyl halides, gave 1-substituted 3-aminomethylene-3H-indolium salts, which were converted to the corresponding 1-substituted 3-indolecarboxaldehydes by hydrolysis. Reaction of I with active methylene compounds proceeded under mild conditions to afford the condensation products in good yields. Successive reaction of I with electrophiles and nucleophiles provided a convenient route to 1,3-disubstituted indole derivatives The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Application of 75629-62-8

The Article related to indolecarboxaldehyde enamine preparation reaction, aminomethyleneindole preparation substitution, indolium salt aminomethylene, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 30, 2011, Jain, Shubha; Bhimireddy, Nagi Reddy; Kolisetty, Sambasiva Rao published an article.Computed Properties of 75629-62-8 The title of the article was L-proline catalyzed Knoevenagel condensation: synthesis of some new indole derivatives and biological activities. And the article contained the following:

Knoevenagel condensation of various heteroaromatic aldehydes with active methylene compounds like malononitrile, Et cyanoacetate, barbituric acid, meldrum’s acid and dimedone proceeds smoothly with stirring under conventional heating. Twenty Knoevenagel condensation products were synthesized with excellent yields. The indole derivatives, e.g., I, were also screened for their antibacterial activity. The work-up procedure is very simple and the products do not require further purification The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Computed Properties of 75629-62-8

The Article related to indole substituted preparation bacterial infection antibacterial activity, indolecarboxaldehyde active methylene knoevenagel condensation proline catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Computed Properties of 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Waghmare, Smita R. published an article in 2021, the title of the article was Ammonium chloride catalyzed Knoevenagel condensation in PEG-400 as ecofriendly solvent.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

A simple and selective green methodol. has been successfully developed for Knoevenagel condensation in polyethylene glycol-400 using 10 mol % ammonium chloride as catalyst. The method is applicable to a wide range of aromatic, heteroaromatic and 伪,尾-unsaturated aldehydes. The reactions have been found to be clean and free from the formation of the Michael adduct. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to alkene preparation stereoselective green chem, aldehyde active methylene compound knoevenagel condensation ammonium chloride peg400, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 30, 2004, Yadav, Jhillu S.; Reddy, Basi V. Subba; Basak, Ashok K.; Visali, Boddapati; Narsaiah, Akkirala Venkat; Nagaiah, Kommu published an article.COA of Formula: C12H7N3 The title of the article was Phosphane-catalyzed Knoevenagel condensation: A facile synthesis of 伪-cyanoacrylates and 伪-cyanoacrylonitriles. And the article contained the following:

Triphenylphosphane has been utilized as an efficient catalyst for the Knoevenagel condensation of aldehydes with acidic methylene compounds such as Et cyanoacetate and malononitrile to afford substituted olefins, e.g., I. The reaction proceeded smoothly under solvent-free conditions and the products were obtained in excellent yields with an E-geometry. This method was applied to a wide range of aldehydes including aromatic, aliphatic and heterocyclic substrates. Microwave irradiation has been used to achieve enhanced reaction rates and improved yields. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).COA of Formula: C12H7N3

The Article related to arylaldehyde cyanoacetate knoevenagel condensation, arylidene cyanoacetate stereoselective preparation, phosphane knoevenagel condensation catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.COA of Formula: C12H7N3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On September 1, 1981, Yamashita, Yoshiro; Suzuki, Daisuke; Masumura, Mitsuo published an article.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Synthesis of vinyl-substituted indolizine derivatives by a novel reaction of indolizines with ethoxyethylenes having electron-withdrawing substituents. And the article contained the following:

The vinylindolizines I (R1 = Me, Ph, p-BrC6H4; R2, R3 = H, Me; R4 = R5 = CN, CO2Et, R4 = CN, COMe; R5 = CO2Et) were prepared in 22-85% yields by Michael addition of the indolizines II with EtOCH:CR4R5. Hydrolysis of I (R1 = Ph, R2 = H, Me; R3 = H, R4 = R5 = CN) gave the corresponding 3-formylindolizines. Pyrrole and 1-methylpyrrole underwent similar addition with EtOCH:C(CN)2 to give the pyrroles III (R = H, Me). The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to indolizine addition ethoxyethylene, vinylindolizine, Heterocyclic Compounds (One Hetero Atom): Other Areno- and Diarenopyridines (Including Also Quinuclidines, etc.) and other aspects.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On March 31, 2016, Muhammad, Munira T.; Khan, Khalid M.; Taha, Muhammad; Khan, Tariq; Hussain, Shafqat; Fakhri, Muhammad I.; Perveen, Shahnaz; Voelter, Wolfgang published an article.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was New Facile, Eco-Friendly and Rapid Synthesis of Trisubstituted Alkenes Using Bismuth Nitrate as Lewis Acid. And the article contained the following:

A facile, eco-friendly and rapid method for Knoevenagel condensations using bismuth nitrate as Lewis acid was presented. In a typical reaction, 1 mmol of aromatic aldehyde with 1.1 mmol of malanonitrile in the presence of bismuth nitrate (3 mmol%) was refluxed in water (10 mL) for 25-30 min. In order to generalize the newly developed methodol., a variety of aldehydes were selected to synthesize different trisubstituted alkenes and it was found that this method can also be applied on aromatic aldehydes. For comparison purposes, the reaction was carried out in ethanol in parallel to water and found that water is the best solvent for this reaction. The advantages of bismuth nitrate as a catalyst were: easy to remove from the reaction mixture by simple filtration, recyclable, required water as solvent, was eco-friendly and afforded high yields (90-97%). The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to aryl aldehyde malononitrile bismuth nitrate catalyst knoevenagel condensation, arylidene malononitrile preparation green chem, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Pippal, Parveen; Singh, Prabal Pratap published an article in 2017, the title of the article was Calcium ferrite, an efficient catalyst for Knoevenagel condensation (A green approach).Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

Calcium ferrite NPs catalyst were used as a cheaper and highly efficient catalyst for Knoevenagel condensation of active methylene substrates with various carbonyl compounds affording condensed products in excellent yields in shorter reaction time. The developed greener protocol was very simple, involving cleaner work up and the synthesized products did not require further purification The catalyst was easily removed and reused at least for four times without any appreciable change in reactivity. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to aryl aldehyde active methylene compound calcium ferrite knoevenagel condensation, cyanoalkene preparation green chem, calcium ferrite catalyst preparation crystallinity, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kaur, Jasreen; Bariwal, Jatinder; Bedi, Preet Mohinder Singh; Kaur, Maninderjit; Kapoor, Amit; Kaur, Mandeep; Verma, Poonam published an article in 2017, the title of the article was Highly efficient synthesis of pyranoquinoline derivatives catalyzed by piperidine.Application In Synthesis of 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

A mild and efficient method for the synthesis of substituted pyranoquinolones I [R = 2-furyl, Ph, 4-ClC6H4, etc.; R1 = CN, COOEt] via a two-component reaction of 4-hydroxy-1-methyl-2(1H)-quinolinone and intermediate arylidenes catalyzed by piperidine was described. The reaction commenced very fast after heating of reaction mixture at 鈮?0掳C for 2-3 h and gives high yields. This new procedure had the advantages of mild reaction condition, high yields and metal-free catalyst. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Application In Synthesis of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to pyranoquinolone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application In Synthesis of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts