Category: 75629-62-8

On September 1, 1981, Yamashita, Yoshiro; Suzuki, Daisuke; Masumura, Mitsuo published an article.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Synthesis of vinyl-substituted indolizine derivatives by a novel reaction of indolizines with ethoxyethylenes having electron-withdrawing substituents. And the article contained the following:

The vinylindolizines I (R1 = Me, Ph, p-BrC6H4; R2, R3 = H, Me; R4 = R5 = CN, CO2Et, R4 = CN, COMe; R5 = CO2Et) were prepared in 22-85% yields by Michael addition of the indolizines II with EtOCH:CR4R5. Hydrolysis of I (R1 = Ph, R2 = H, Me; R3 = H, R4 = R5 = CN) gave the corresponding 3-formylindolizines. Pyrrole and 1-methylpyrrole underwent similar addition with EtOCH:C(CN)2 to give the pyrroles III (R = H, Me). The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to indolizine addition ethoxyethylene, vinylindolizine, Heterocyclic Compounds (One Hetero Atom): Other Areno- and Diarenopyridines (Including Also Quinuclidines, etc.) and other aspects.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

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On March 31, 2016, Muhammad, Munira T.; Khan, Khalid M.; Taha, Muhammad; Khan, Tariq; Hussain, Shafqat; Fakhri, Muhammad I.; Perveen, Shahnaz; Voelter, Wolfgang published an article.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was New Facile, Eco-Friendly and Rapid Synthesis of Trisubstituted Alkenes Using Bismuth Nitrate as Lewis Acid. And the article contained the following:

A facile, eco-friendly and rapid method for Knoevenagel condensations using bismuth nitrate as Lewis acid was presented. In a typical reaction, 1 mmol of aromatic aldehyde with 1.1 mmol of malanonitrile in the presence of bismuth nitrate (3 mmol%) was refluxed in water (10 mL) for 25-30 min. In order to generalize the newly developed methodol., a variety of aldehydes were selected to synthesize different trisubstituted alkenes and it was found that this method can also be applied on aromatic aldehydes. For comparison purposes, the reaction was carried out in ethanol in parallel to water and found that water is the best solvent for this reaction. The advantages of bismuth nitrate as a catalyst were: easy to remove from the reaction mixture by simple filtration, recyclable, required water as solvent, was eco-friendly and afforded high yields (90-97%). The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to aryl aldehyde malononitrile bismuth nitrate catalyst knoevenagel condensation, arylidene malononitrile preparation green chem, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

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On January 31, 2022, Chakraborty, Sourav; Rudra Paul, Abhijit; Majumdar, Swapan published an article.Name: 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Base and metal free true recyclable medium for Knoevenagel condensation reaction in SDS-ionic liquid-aqueous miceller composite system. And the article contained the following:

This paper presents for the first time a base and metal free procedure for Knoevenagel condensation reaction in a neutral medium comprises water-SDS-imidazolium ionic liquid composite system. Knoevenagel condensation products from the different aromatic aldehydes and active methylene compounds such as malononitrile, Et cyanoacetate or cyano acetic acid provides good to excellent yields in all cases examined at 80掳C. The developed protocol has several advantages such as chromatog. and organic volatile solvent free protocol, short reaction time and recyclability of catalyst including reaction waste. The reaction is believed to proceed in the hydrophobic cavity of the micelle formed in the medium which was proved by dynamic light scattering studies. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Name: 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to aryl aldehyde active methylene compound knoevenagel condensation green chem, sds ionic liquid aqueous miceller composite system, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Name: 2-((1H-Indol-3-yl)methylene)malononitrile

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Nitrile – Wikipedia,
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Badiger, Krishnappa B.; Kamanna, Kantharaju published an article in 2021, the title of the article was Knoevenagel condensation reaction catalysed by agro-waste extract as a greener solvent catalyst.Name: 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

This paper present a novel Knoevenagel reaction protocol for the condensation of aromatic/heteroaromatic aldehydes RCHO (R = 2-phenylethenyl, naphthalen-1-yl, furan-2-yl, 1H-indol-3-yl, etc.) with malononitrile to give 伪, 尾-unsaturated benzylidene derivs RCH=C(CN)2. The main focus of this work is to reveal the usability of agro-waste extracts as a catalyst in the Knoevenagel condensation. In addition, the present method describes direct isolation of the formed products without using organic solvent extraction and gives good yields product. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Name: 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to unsaturated benzylidene preparation green chem, aryl aldehyde malononitrile knoevenagel condensation agro waste extract catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Name: 2-((1H-Indol-3-yl)methylene)malononitrile

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Pippal, Parveen; Singh, Prabal Pratap published an article in 2017, the title of the article was Calcium ferrite, an efficient catalyst for Knoevenagel condensation (A green approach).Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

Calcium ferrite NPs catalyst were used as a cheaper and highly efficient catalyst for Knoevenagel condensation of active methylene substrates with various carbonyl compounds affording condensed products in excellent yields in shorter reaction time. The developed greener protocol was very simple, involving cleaner work up and the synthesized products did not require further purification The catalyst was easily removed and reused at least for four times without any appreciable change in reactivity. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to aryl aldehyde active methylene compound calcium ferrite knoevenagel condensation, cyanoalkene preparation green chem, calcium ferrite catalyst preparation crystallinity, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

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Nitrile – Wikipedia,
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On November 29, 1984, Aariin, Kei Masaa; Piitaa, Maachin Koerushu published a patent.Formula: C12H7N3 The title of the patent was Optical filters for photoimaging materials. And the patent contained the following:

Optical filters contain 鈮? dye(s) selected from benzylidene and naphthalimide dyes and a binder composition containing phenol-formaldehyde resin in amount sufficient to cause optical shift in the absorption spectra of the dye(s). The filters are especially useful for UV- and visible light-sensitive photoimaging systems, and especially useful as photog. halation inhibiting layers. Thus, Disperse Yellow 31 60, Butvar B-76 (a butyral resin) 108, Resinox RS 7280 (a phenolic resin) modified with DD1-1410 (a diisocyanate compound) 1440 and MeCOEt 1720 g were mixed to give a halation inhibitor coating composition The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Formula: C12H7N3

The Article related to halation inhibitor photog benzylidene dye, naphthalimide dye photog halation inhibitor, binder photog halation inhibiting layer, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Silver Halide Photographic Chemistry and Processes and other aspects.Formula: C12H7N3

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Kaur, Jasreen; Bariwal, Jatinder; Bedi, Preet Mohinder Singh; Kaur, Maninderjit; Kapoor, Amit; Kaur, Mandeep; Verma, Poonam published an article in 2017, the title of the article was Highly efficient synthesis of pyranoquinoline derivatives catalyzed by piperidine.Application In Synthesis of 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

A mild and efficient method for the synthesis of substituted pyranoquinolones I [R = 2-furyl, Ph, 4-ClC6H4, etc.; R1 = CN, COOEt] via a two-component reaction of 4-hydroxy-1-methyl-2(1H)-quinolinone and intermediate arylidenes catalyzed by piperidine was described. The reaction commenced very fast after heating of reaction mixture at 鈮?0掳C for 2-3 h and gives high yields. This new procedure had the advantages of mild reaction condition, high yields and metal-free catalyst. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Application In Synthesis of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to pyranoquinolone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application In Synthesis of 2-((1H-Indol-3-yl)methylene)malononitrile

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Nitrile – Wikipedia,
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Magar, Rupali L.; Thorat, Prashant B.; Waware, Jagdish L.; More, Rameshwar R.; Solanke, Usha A.; Patil, Bhagwan R.; Pawar, Rajendra P. published an article in 2015, the title of the article was Synthesis of Some Novel 3-Substituted Indole Derivatives Using Polyamine Functionalized Heterogeneous Catalyst.Recommanded Product: 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

In present work, we have described the use of polyamine solid supported GN3 as catalyst in organic transformations using 1H-indole-3-carbaldehyde. To the best of our knowledge, reports for the synthesis of chromene substituted at 3C position of indole are extremely rare in the literature. The polyamine functionalized immobilized silica (GN3) was found to be an excellent catalyst for synthesis of novel 2-amino-4-(1H-indol-3-yl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile derivatives and Knoevenagel condensation. Catalyst GN3 was able to furnish excellent yield for a wide range of products. Moreover, the catalyst was reusable and reused for several times without loss of its catalytic activity. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Recommanded Product: 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to indole preparation gn3 reusability catalyst mechanism nucleophile condensation reaction, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Recommanded Product: 2-((1H-Indol-3-yl)methylene)malononitrile

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On March 31, 2021, Ramana Reddy, Ch. Venkata; Reddy, G. Ganga published an article.HPLC of Formula: 75629-62-8 The title of the article was Simple, Stepwise and Alternative Syntheses of Indolyl Triazoles via Huisgen’s 1,3-dipolar Cycloaddition Reaction. And the article contained the following:

A series of new 2-((1-((1-(4-methoxy-3-nitrophenyl)-1H-1,2,3-triazol-4-yl)methyl)1H-indol-3-yl)methylene)malononitrile derivatives I (X = H, NO2, Br; R1 = H, NO2; R2 = Me, OMe, CN) were synthesized by the 1,3-dipolar cycloaddition reaction (click reaction) of 2-((1-(prop-2-yn-1-yl)-1H-indol-3-yl)methylene)malononitrile with different aryl azides in the presence of sodium ascorbate and copper sulfate in good yields. The advantages of this method are efficient, clean, high yields, easy workup procedures, and shorter reaction time. These reactions are very facile, giving products by simple processing that does not require purification by column chromatog. Spectroscopic methods confirmed all the newly synthesized compounds The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).HPLC of Formula: 75629-62-8

The Article related to indolyl triazole preparation, propynyl indolyl methylene malononitrile aryl azide huisgens dipolar cycloaddition, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.HPLC of Formula: 75629-62-8

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Mandour, A. H.; Fathalla, O. A.; Basyouni, W. M. published an article in 2000, the title of the article was Synthesis of 2-(3-indolyl)-3,5-dihydro-[1,2,4]triazolo-[1,5-a]-5-pyridone and 2-pyridone derivatives.Recommanded Product: 75629-62-8 And the article contains the following content:

Indole-3-carboxaldehyde condensed with cyanoacetohydrazide to yield 3-indolylidinecyanoacetohydrazide (I). I condensed with different arylidenemalononitriles in presence of a base to give 7-aryl-6,8-dicyano-2-(3-indolyl)[1,2,4]triazolo[1,5-a]-pyridin-5-ones. Also, the condensation of I with different Et arylidenecyanoacetates gave the corresponding 4-aryl-3,5-dicyano-6-hydroxy-N-1-(3-indolylidine)pyridin-2-ones. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Recommanded Product: 75629-62-8

The Article related to indolyltriazolopyridinone preparation, triazolopyridinone indolyl preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 75629-62-8

Referemce:
Nitrile – Wikipedia,
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