Category: 7357-70-2

Application of 7357-70-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7357-70-2, name is 2-Cyanothioacetamide, This compound has unique chemical properties. The synthetic route is as follows.

N-Methylmorpholine (10 drops) was added to a mixture of cyanothioacetamide 1 (4.00 g, 0.04 mol) [5] and indole-3-carbaldehyde (5.80 g, 0.04 mol) in 50 mL of 96% EtOH. The mixture was refluxed for 5 min with stirring. After cooling the resulting red solution, the precipitate formed, which was filtered off after 24 h, washed with diethyl ether, and dried. Yield 5.50 g (61%), yellow powder, mp 169-172C (EtOH) (mp 174-176C [37]). IR spectrum, nu, cm-1: 3320 (N-H), 2215 (C?N). 1H NMR spectrum, delta, ppm: 7.15-7.22 m (3H, H-Ar), 7.88-7.93 m (1H, H-Ar), 8.54 d (1H, H2, J = 2.9 Hz), 8.64 s (1H, CH=), 9.01 br.s (1H, CSNH2), 9.44 br.s (1H, CSNH2), 12.24 br.s (1H, NH). 13C NMR spectrum, deltaC, ppm: 104.1 (C-C?N), 108.2 (C3, indole), 115.0 (CH-Ar), 116.9 (C?N), 120.5 (CH-Ar), 122.9 (CH-Ar), 123.8 (CH-Ar), 129.7 (C-Ar), 135.0 (C-Ar), 138.7 (C-Ar), 142.1 [CH=C(C?N)], 190.3 (C=S). Found, %: C 63.57; H 4.12; N 18.33. C12H9N3S. Calculated, %: C 63.41; H 3.99; N 18.49.

The chemical industry reduces the impact on the environment during synthesis 2-Cyanothioacetamide. I believe this compound will play a more active role in future production and life.

Reference:
Article; Dotsenko; Krivokolysko; Krivokolysko; Frolov; Russian Journal of General Chemistry; vol. 88; 4; (2018); p. 682 – 688; Zh. Obshch. Khim.; vol. 88; 4; (2018); p. 599 – 605,7;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7357-70-2, name is 2-Cyanothioacetamide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 2-Cyanothioacetamide

To a suspension of 3-(l,2-dimethyl-lH-imidazol-5-yl)-l-(thiazol-2- yl)prop-2-en-l-one (0.31 mmol, 72 mg) and 2-cyanothioacetamide (0.93 mmol, 93 mg, 3.0 equiv.) in EtOH (1.5 mL), a few drops of piperidine were added. After being stirred at 80C for 2 h, EtOH was evaporated and crude product was redissolved in CH3CN. (0432) Butyl(chloromethyl)sulfane (0.62 mmol, 85.5 mg) and Et3N (0.93 mmol, 94.1 mg, 130 mu) were then added and the reaction mixture was stirred at 80C for 20 min. Once complete, the reaction was diluted with EtOAc and water. The organic phase was separated and aqueous layer was extracted twice with EtOAc. The combined extractions were washed with saturated NaCl solution, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography to give 99 mg of designed product (77%). H NMR (400 MHz, CDC13) delta 7.96 (d, / = 3.1 Hz, 1H), 7.85 (s, 1H), 7.56 (d, / = 3.1 Hz, 1H), 7.37 (s, 1H), 4.49 (s, 2H), 3.60 (s, 3H), 2.72 (t, / = 7.4 Hz, 2H), 2.48 (s, 3H), 1.62 (p, / = 7.3 Hz, 2H), 1.40 (h, / = 7.3 Hz, 2H), 0.90 (t, / = 7.3 Hz, 3H). ESI- MS (m/z): 416.6 [M+H]+.

The synthetic route of 7357-70-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CASE WESTERN RESERVE UNIVERSITY; MARKOWITZ, Sanford; GERSON, Stanton; DESAI, Amar; HO, Won Jin; (185 pag.)WO2016/144958; (2016); A1;,
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Related Products of 7357-70-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7357-70-2, name is 2-Cyanothioacetamide, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of the required acetophenones (0.001 mol),the appropriate aromatic aldehydes (0.001 mol), cyanothioacetamide(0.1 g, 0.001 mol) and ammonium acetate (0.62 g,0.008 mol) in n-butanol (10 mL) is irradiated at 150C for20 min in the microwave oven. After the reaction mixture iscooled to room temperature, the reaction mixture is dilutedwith 10 mL diethyl ether and the separated solid is filtered,dried and crystallized from ethanol to afford compounds 4-10.1,2-Dihydro-6-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-2-thioxopyridine-3-carbonitrile (4)Yellow powder, yield: 0.35g (87%), mp: 294-296C. IR(KBr, cm-1): 3421 (NH), 3066 (CH-aromatic), 2843 (CHaliphatic),2222 (CN), 1136 (C=S). 1H-NMR (400 MHz, dimethylsulfoxide (DMSO)-d6), delta ppm: 3.73 (s, 3H, OCH3),3.85 (s, 3H, OCH3), 3.88 (s, 6H, 2OCH3), 6.88 (s, 1H, Ar-H),7.13 (d, 2H, J=7.5 Hz, Ar-H), 7.20 (s, 2H, Ar-H), 7.72 (d, 2H,J=7.7 Hz, Ar-H), 12.53 (s, 1H, NH, D2O exchangeable).13CNMR(100 MHz, DMSO-d6), delta ppm: 55.9, 56.2 (2C), 56.7,97.7, 102.3, 105.8 (2C), 114.6 (2C), 117.4, 128.6, 129.5, 130.5(2C), 140.4, 153.5 (2C), 155.9, 161.5, 167, 169. Anal. Calcd for:C22H20N2O4S (408.47): C, 64.69; H, 4.94; N, 6.86. Found: C,64.93; H, 5.07; N, 7.04.

The chemical industry reduces the impact on the environment during synthesis 2-Cyanothioacetamide. I believe this compound will play a more active role in future production and life.

Reference:
Article; Elhameid, Mohammed K. Abd; Ryad, Noha; My, Al-Shorbagy; Mohammed, Manal R.; Ismail, Mohammed M.; El Meligie, Salwa; Chemical and Pharmaceutical Bulletin; vol. 66; 10; (2018); p. 939 – 952;,
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