Synthetic Route of 7251-09-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7251-09-4, name is 4-Amino-2-methoxybenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
(a) Synthesis of tert-butyl 4-cyano-3-methyl-3-methoxyphenylcarbamate A solution of sodium hydroxide (0.566 g, 14.2 mmol) in water (6 ml) was added to a solution of the 4-amino-2-methoxybenzonitrile obtained in Example 74 (2 g, 13.5 mmol) in a mixture of t-butanol (10 ml) and tetrahydrofuran (3 ml), followed by adding dropwise thereto a solution of di-tert-butyl dicarbonate (3.09 g, 14.2 mmol) in t-butanol (2 ml), and the resulting mixture was stirred at room temperature for 4 days. During the stirring, di-tert-butyl dicarbonate (11.9 g, 54.5 mmol) and sodium hydroxide (2.18 g, 54.5 mmol) were added thereto. The reaction mixture was poured into ice water and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate and then filtered. The filtrate was concentrated under reduced pressure and the resulting residue was purified by a silica gel column chromatography (eluent: hexane/ethyl acetate = 3/1 to 2/1) to obtain tert-butyl 4-cyano-3-methyl-3-methoxyphenylcarbamate (1.87 g, 56%).
The synthetic route of 4-Amino-2-methoxybenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1500643; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts