In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 72035-46-2 as follows. Quality Control of 2,3-Bis(4-methoxyphenyl)propanenitrile
In the first step, formation of the substituted stilbene occurred through basic addition of 2-(4-methoxyphenyl)acetonitrile to 4-methoxybenzaldehyde in high yield. Reduction of the stilbene using NaBH4 to afford 2,3-bis(4-methoxyphenyl)propanenitrile was followed bytreatment with BBr3 to cleave the methyl ethers, giving DPN in high yield.DPN was then acetylated using acetic anhydride to provide Compound 1. Either the corresponding anhydride or acyl chloride was used to provide Compounds 2-6.For an exemplary synthesis of the R-enantiomer of DPN, see Carroll, VM. et al., J. Med. Chem. 2012 55:528-537.
According to the analysis of related databases, 72035-46-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; JUNG, Michael, E.; VOSKUHL, Rhonda, R.; (58 pag.)WO2018/49094; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts