Related Products of 70484-02-5,Some common heterocyclic compound, 70484-02-5, name is 6-Bromonaphthalene-2,3-dicarbonitrile, molecular formula is C12H5BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Synthetic Example 28 [Synthesis of 2,3-dicyano-6-(3′,5′-dimethoxycarbonylphenylthio)naphthalene] 10 Grams (38.9 mmols) of the 6-bromo-2,3-dicyanonaphthalene obtained in Synthetic Example 2 and 12.9 g (44.7 mmols) of copper (I) 3,5-dimethoxycarbonylphenylthiolate were stirred in 200 ml of quinoline at 160 C. for 10 hours. After cooling, the reaction mixture was poured into 600 ml of methanol/water (1/1) and the resulting mixture was allowed to stand overnight. The precipitate formed was filtered and sufficiently washed with methanol. The solid thus obtained was transferred to a Soxhlet extractor and extracted with acetone for 20 hours. The acetone solution thus obtained was concentrated, after which methanol was added and the solid precipitated was filtered and sufficiently washed with methanol. The solid thus treated was purified by a silica gel column chromatography (eluent: ethyl acetate) and then recrystallized from acetone to obtain 4.32 g of colorless crystals. The crystals were confirmed to be 2,3-dicyano-6-(3′,5′-dimethoxycarbonylphenylthio)naphthalene from the following analysis results:
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Bromonaphthalene-2,3-dicarbonitrile, its application will become more common.
Reference:
Patent; Hitachi Chemical Company; US5438135; (1995); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts