Category: 70484-01-4

Adding a certain compound to certain chemical reactions, such as: 70484-01-4, name is 4-Bromophthalonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 70484-01-4, SDS of cas: 70484-01-4

4-bromo-phthalonitrile (0.414 g), 4-borate-4′,4′-dimethoxytriphenylamine (1.725 g), Tetrakis(triphenylphosphine)palladium (0.231 g) and potassium carbonate (2.764 g) were placed in a mixed solution of water (3 mL) and tetrahydrofuran (50 mL). Nitrogen gas was used as a shielding gas, and aeration-degassing was carried out three times to obtain a nitrogen atmosphere. Then, the mixture was stirred at 80 C for 12 hours. After the reaction was completed, the reaction solution was cooled to room temperature, and magnesium sulfate was added to remove water; the solution after water removal was dried. To obtain a solid product, The obtained solid product was subjected to column chromatography using an eluent (petroleum ether: ethyl acetate: dichloromethane in a volume ratio of 20:1:2); after column chromatography, The obtained solution was spin-dried to obtain an phthalic acid derivative, which was confirmed by nuclear magnetic analysis.Its structure is as shown in Formula I, which is 4-o-phenylenedicyano-4′,4′-dimethoxytriphenylamine. The nuclear magnetic analysis chart is shown in Figure 1;

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromophthalonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; South University of Science and Technology of China; Xu Zongxiang; Feng Yaomiao; Hu Qikun; (18 pag.)CN109651197; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

70484-01-4, name is 4-Bromophthalonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 4-Bromophthalonitrile

A stirrer,thermometer,condenser,A 100 mL four-necked glass flask equipped with a glass stopper was purged with nitrogen,The open end of the condenser was sealed with a gentle stream of nitrogen. Bis (dibenzylideneacetone) platinum (0) (6.6 mg, 0.01 mmol),4-Bromophthalonitrile (207 mg, 1.0 mmol) and N-methylpyrrolidone (4 mL) were charged,The flask contents were stirred at room temperature to dissolve the solids. Triethylamine (304 mg,3.0 mmol) was added,1, 1, 1, 3, 5, 5, 5-heptamethyltrisiloxane (178 mg, 0.8 mm pl) was slowly added and stirred at 19 to 22 C for 17 hours. Bis (dibenzylideneacetone) platinum (0) (6.6 mg, 0.01 mmol) was added,1,1,1,3,5,5,5-heptamethyltrisiloxane (178 mg, 0.8 mm pl)Was added slowly and stirring was continued at 19 to 22 C. for 12 hours. By gas chromatography mass spectrometry (GC-MS) of the reaction mixture,Formation of the target compound was confirmed.

The synthetic route of 70484-01-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SHIN-ETSU CHEMICAL COMPANY LIMITED; KIYOMORI, AYUMU; ITOH, YUSUKE; (49 pag.)JP2015/10084; (2015); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 70484-01-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 70484-01-4, name is 4-Bromophthalonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

In a 250 ml round bottom flask, H001-3 (15 mmol), cuprous iodide (30 mmol),t-BuOK (20 mmol) and 3,4-dicyanobromobenzene (30 mmol) were mixed with dry 1,4-dioxane (100 ml) and stirred at room temperature for 48 hours under a nitrogen atmosphere.The resulting intermediate was added to water, then filtered through a pad of celite, and the filtrate was extracted with dichloromethane.It was then washed with water and dried over anhydrous magnesium sulfate. After filtration and evaporation, the crude product was purified by silica gel column chromatography to obtain the intermediate product H002.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromophthalonitrile, other downstream synthetic routes, hurry up and to see.

Related Products of 70484-01-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 70484-01-4, name is 4-Bromophthalonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Compound B-3 (8.4 mmol) and Compound E-4 (2.8 mmol) were reacted in the presence of DBU (11.2 mmol)And reacted under n-pentanol reflux conditions to obtain compound F-1 (0.28 mmol, 10%).To compound F-1 (0.28 mmol) in DMF,Zinc acetate was added and the mixture was stirred at 80 C. for 2 hours to obtain F-2 (0.25 mmol, 90%).F-2 (0.25 mmol) was dissolved in dichlorobis (triphenylphosphine) palladium (II) (PdCl 2 (PPh 3) 2)After cross coupling with triisopropylsilylacetylene in the presence of copper iodide,Treated with tetra-n-butylammonium fluoride (TBAF)Compound F-3 (0.19 mmol, 76%) was obtained.Compound F-3 (0.19 mmol) was cross-coupled with 4-iodobenzoic acid to obtain phthalocyanine dye D-2 (0.11 mmol, 58%).

The chemical industry reduces the impact on the environment during synthesis 4-Bromophthalonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; NIPPON STEEL & SUMIKIN CHEMICAL COMPANY LIMITED; KYUSHU INSTITUTE OF TECHNOLOGY; HAYASE, SHUZI; PANDEY, SHYAM SUDHIR; YAMAGUCHI, YOSHIHIRO; OCHI, NORIAKI; FUJINO, KENICHI; OKAMOTO, ETSUYA; KOMAYA, YOHEI; (25 pag.)JP5906522; (2016); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 70484-01-4, name is 4-Bromophthalonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 70484-01-4, Quality Control of 4-Bromophthalonitrile

A stirrer,thermometer,condenser,A 100 mL four-necked glass flask equipped with a glass stopper was purged with nitrogen,The open end of the condenser was sealed with a gentle stream of nitrogen. Palladium acetate (1.1 mg, 0.005 mmol),2-dicyclohexylphosphino-2 ‘, 6’-dimethoxybiphenyl (4.1 mg, 0.01 mmol),4-bromophthalonitrile (104 mg, 0.5 mmol),4,4,5,5-tetramethyl-2- [p- (1,1,1,3,5,5,5-heptamethyltrisiloxane-3-yl) phenyl] -1,3- – borolane (255 mg, 0.6 mmol),And 1,4-dioxane (2 mL) were charged in a flask,The solid was dissolved by stirring at room temperature for 30 minutes. Cesium carbonate (326 mg, 1.0 mmol)Was added and the mixture was stirred at 25-29 C. for 12 days. Production of the target compound was confirmed by GC-MS of the reaction mixture.5 mL of toluene and 5 mL of water were added in order to the reaction mixture, and the mixture was stirred at room temperature for 5 minutes, then separated, and the organic layer was concentrated under reduced pressure.The residue was dissolved in toluene, filtered through 10 g of activated alumina, and the obtained crude product was purified by preparative GPC to obtain 142 mg of the objective compound as a white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; SHIN-ETSU CHEMICAL COMPANY LIMITED; KIYOMORI, AYUMU; ITOH, YUSUKE; (49 pag.)JP2015/10084; (2015); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts