Category: 7048-38-6

Reference of 7048-38-6,Some common heterocyclic compound, 7048-38-6, name is (5-Chloro-2-methoxyphenyl)acetonitrile, molecular formula is C9H8ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To an ice-cooled and stirred mixture of 1 -azido-2,4-dichloro-benzene (0.9 g, 1 eq) and commercial (5-chloro-2-methoxy-phenyl)-acetonitrile (1 .04 g, 1 .2 eq) in ethanol (10 ml) kept under nitrogen, a solution of sodium methoxide (0.388 g, 1 .5 eq) in ethanol (10 ml) is added drop-wise (20 min). After the addition, the reaction mixture is allowed to reach room temperature spontaneously and stirring is then continued overnight at room temperature. The resulting reaction mixture is diluted with ethyl acetate (40 ml), washed with water (2 x 50 ml), dried over MgSO4 and evaporated to dryness. The yellow solid residue (0.820 g) is purified by crystallization from a mixture of dichloromethane and hexane (1 : 1 ), to afford the title compound as white solid (0.480 g, 28percent yield). M.p. 153.5-154.7°C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (5-Chloro-2-methoxyphenyl)acetonitrile, its application will become more common.

Reference:
Patent; NeuroSearch A/S; WO2009/19278; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 7048-38-6, name is (5-Chloro-2-methoxyphenyl)acetonitrile, molecular formula is C9H8ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C9H8ClNO

(a) 2-Methoxy-5-chloro-alpha-isopropylbenzyl cyanide To a stirred suspension of sodium hydride (2.4 g) in dimethylformamide (100 ml) was added a solution of 2-bromopropane and 2-methoxy-5-chlorobenzyl cyanide (18.2 g) in dry dimethylformamide (50 ml), keeping the temperature at 20°-30° C. The mixture was then stirred for 30 minutes, water was added cautiously, and the mixture was then poured into ice-water. Hydrochloric acid was then added and the mixture was extracted with dichloromethane, washed with water then with sodium chloride solution, then dried over magnesium sulphate, filtered, and the solvent was then removed to give 25 g of a brown oil. Distillation gave the title product (15 g) as a colourless oil, bp 180° C./20 mm Hg.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7048-38-6, its application will become more common.

Reference:
Patent; Fisons Limited; US4263037; (1981); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7048-38-6 as follows. Recommanded Product: (5-Chloro-2-methoxyphenyl)acetonitrile

To a solution of 2-(5-chloro-2-methoxyphenyl)acetonitrile (lOg, 47.84mmol) in ethyl formate (50mL) was added sodium metal (4.4g, 95.6mmol) at room temperature. The resulting reaction mixture was heated at 100°C for 3 hours. After completion of the reaction, it was cooled to room temperature, water (100ml) and dichloromethane (100ml) were added to the reaction mixture and the solution was adjusted to pH-3 with the help of concentrated hydrochloric acid. The layers were separated and the aqueous layer was extracted with dichloromethane (2 x 100ml). The combined organics were washed with saturated aqueous sodium chloride solution (150ml), dried over sodium sulphate, filtered and evaporated in vacuo. The crude product was purified by column chromatography using normal phase silica gel. The desired product eluted at around 0.7 to 0.9percent methanol in dichloromethane. Evaporation of the product fractions gave 9g (yield, 77.94percent) of the desired compound as a white solid. LC-MS: m/z = 208.0(M-H).

According to the analysis of related databases, 7048-38-6, the application of this compound in the production field has become more and more popular.

Related Products of 7048-38-6, These common heterocyclic compound, 7048-38-6, name is (5-Chloro-2-methoxyphenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound Z-0-7 (32 g, 177 mmol) was dissolved in methyl formate (400 mL)plusInsodium(8.14 g, 354 mmol).The mixture was protected under nitrogen,Heated to reflux for 24 hThe reaction mixture was cooled to room temperature,Add water to quench the reaction,Ethyl acetate extraction (400 x 2 mL),The combined organic phases were washed with water (200 x 2 mL),Dried over anhydrous sodium sulfate,A yellow solid, Z-0-8 (10.5 g, yield: 28.4percent) was obtained.

The synthetic route of 7048-38-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangzijiang Pharmaceutical Group Co., Ltd.; Lan Jiong; Zhou Fusheng; Huang Dong; Shi Xia; (30 pag.)CN106243003; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts