Category: 70291-62-2

Design, characterisation and anticonvulsant evaluation of thienopyrimidinone derivatives synthesised by green chemistry was written by Raju, Gollapalli Naga;Sucharitha, Nallamothu;Navya, Nagandla;Nadendla, Rama Rao. And the article was included in Journal of Chemical and Pharmaceutical Research in 2017.COA of Formula: C8H8N2S This article mentions the following:

The synthesis and biol. evaluation of some novel thieno[2,3-d]pyrimidin-4(3H)one derivatives was aimed at creating a new scaffold. Considering the previous articles activity profile of thienopyrimidinone derivatives, fifteen new substituted thieno[2,3-d]pyrimidin-4(3H)one derivatives were synthesized by reacting different 2-amino-4,5-substituted thiophene-3-carbonitriles with appropriate aliphatic carboxylic acids in presence of phosphoryl trihloride and alumina by conventional synthesis as well as microwave assisted route. Structural characterizations of all the synthesized compounds were performed by using spectral and elemental anal. All the synthesized compounds were evaluated for their antimicrobial and anticonvulsant activities by using disk diffusion method and maximal electroshock induced seizures (MES) method. It was found that the compounds possessed potent antimicrobial and anticonvulsant activities. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2COA of Formula: C8H8N2S).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.COA of Formula: C8H8N2S

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthesis of novel fused thienodiazaphosphorine derivatives from 2-amino-3-cyanothiophenes and Lawesson’s reagent was written by Khalladi, Khaoula;Touil, Soufiane. And the article was included in Journal of Sulfur Chemistry in 2012.Formula: C8H8N2S This article mentions the following:

In a simple one-pot procedure, treatment of 2-amino-3-cyanothiophenes with Lawesson’s reagent led to the new thieno[2,3-d][1,3,2]diazaphosphorine-6-thione-2-sulfides in good to excellent yields. A possible reaction mechanism, involving a Dimroth-type rearrangement, was proposed. The structure of obtained products was confirmed by NMR (¹H, ³¹P, and ¹³C) and IR spectroscopies and by mass spectrometry. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Formula: C8H8N2S).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Formula: C8H8N2S

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Microwave-accelerated Gewald reaction. Synthesis of 2-aminothiophenes was written by Sridhar, Madabhushi;Rao, Rayankula Mallikarjuna;Baba, Nanduri H. K.;Kumbhare, Ravindra M.. And the article was included in Tetrahedron Letters in 2007.Recommanded Product: 70291-62-2 This article mentions the following:

Microwave-promoted synthesis of 2-aminothiophenes by multicomponent reactions of a ketone with an active nitrile and elemental sulfur under KF-alumina catalysis is described. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Recommanded Product: 70291-62-2).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Recommanded Product: 70291-62-2

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Preparation and characterization of ZnO/nanoclinoptilolite as a new nanocomposite and studying its catalytic performance in the synthesis of 2-aminothiophenes via Gewald reaction was written by Javadi, Farzad;Tayebee, Reza. And the article was included in Microporous and Mesoporous Materials in 2016.Category: nitriles-buliding-blocks This article mentions the following:

The nanocomposite ZnO/nanoclinoptilolite (ZnO/NCP) was prepared and used as an efficient heterogeneous catalyst in the synthesis of 2-aminotiophene derivatives by Gewald reaction. The nanocomposite was prepared through impregnation of the nanoclinoptilolite (NCP) surface with zinc chloride solution through Zn²⁺ ion exchange, followed by calcination at 500° for 24 h. The synthesized nanocomposite was characterized by XRD, SEM, FESEM, FT-IR, ICP, and nitrogen adsorption/desorption isotherm. The obtained catalytic assays demonstrated that the catalytic activity of ZnO/NCP nanocomposite was increased with enhancing the amount of ZnO. Moreover, the prepared nanocomposite showed very good stability and reusability in the titled synthetic method under aerobic and mild conditions. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Category: nitriles-buliding-blocks).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Category: nitriles-buliding-blocks

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Nitrile – Wikipedia,
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Gewald reaction catalyzed by KF/nano-γ-Al₂O₃ under microwave irradiation was written by Hong, Zhi;Li, Xu-yao;Chen, Can-li;Chen, Guang;Wang, Han-qing;Lu, Chen-chen. And the article was included in Huaxue Shiji in 2015.HPLC of Formula: 70291-62-2 This article mentions the following:

2-Aminothiophenes were synthesized by three components Gewald reaction using KF/nano-γ-Al₂O₃ as the base catalyst with microwave irradiation method. The effects of different reaction conditions on yield were investigated. This method has advantages of using cheap and high-efficient catalyst, simple purification, short reaction time and high product yield. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2HPLC of Formula: 70291-62-2).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).HPLC of Formula: 70291-62-2

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Structure-guided optimization of inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis was written by Punetha, Ankita;Ngo, Huy X.;Holbrook, Selina Y. L.;Green, Keith D.;Willby, Melisa J.;Bonnett, Shilah A.;Krieger, Kyle;Dennis, Emily K.;Posey, James E.;Parish, Tanya;Tsodikov, Oleg V.;Garneau-Tsodikova, Sylvie. And the article was included in ACS Chemical Biology in 2020.Category: nitriles-buliding-blocks This article mentions the following:

The enhanced intracellular survival (Eis) protein of Mycobacterium tuberculosis (Mtb) is a versatile acetyltransferase that multiacetylates aminoglycoside antibiotics abolishing their binding to the bacterial ribosome. When overexpressed as a result of promoter mutations, Eis causes drug resistance. In an attempt to overcome the Eis-mediated kanamycin resistance of Mtb, we designed and optimized structurally unique thieno[2,3-d]pyrimidine Eis inhibitors toward effective kanamycin adjuvant combination therapy. We obtained 12 crystal structures of enzyme-inhibitor complexes, which guided our rational structure-based design of 72 thieno[2,3-d]pyrimidine analogs divided into three families. We evaluated the potency of these inhibitors in vitro as well as their ability to restore the activity of kanamycin in a resistant strain of Mtb, in which Eis was upregulated. Furthermore, we evaluated the metabolic stability of 11 compounds in vitro. This study showcases how structural information can guide Eis inhibitor design. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Category: nitriles-buliding-blocks).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Category: nitriles-buliding-blocks

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Nitrile – Wikipedia,
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Synthesis and antimicrobial evaluation of new 4-{[(aryl)methylene]amino}-2-methyl-5,6-substituted thieno[2,3-d]pyrimidines was written by Naresh, K.;Rajeshwar, Y.;Jayaveera, K. N.. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2014.Application of 70291-62-2 This article mentions the following:

A new series of 4-{[(aryl)methylene]amino}-2-methyl-5,6-substituted thieno[2,3-d]pyrimidines I (R₁R₂ = (CH₂)₃, (CH₂)₅; Ar = C₆H₅, 4-ClC₆H₄, 4-BrC₆H₄, 3-indolyl, etc.) was synthesized by the condensation of 4-amino-2,5,6-substituted theino[2,3-d]pyrimidines II with nine aromatic aldehydes. The compounds were further evaluated for the antibacterial and antifungal activity employing disk diffusion method. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Application of 70291-62-2).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Application of 70291-62-2

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Easy single-step preparation of ZnO nanoparticles by sedimentation method and studying their catalytic performance in the synthesis of 2-aminothiophenes via Gewald reaction was written by Tayebee, Reza;Javadi, Farzad;Argi, Gholamreza. And the article was included in Journal of Molecular Catalysis A: Chemical in 2013.Product Details of 70291-62-2 This article mentions the following:

Zinc oxide is a multi-purpose active material with important catalytic applications. Nano-sized ZnO particles were easily synthesized through sedimentation of zinc acetate di-hydrate in absolute ethanol and were characterized by XRD and SEM. The XRD results indicated pure wurtzite structure with the average particle size of 26.9 nm for the nano-particles. Size of ZnO nano-particles was decreased while solution concentration was increased. This observation would be explained considering enhancing nucleation processes of nano-particles at high concentration of zinc acetate. The prepared nano-particles (2.5 mol%) were used as catalyst for the fast and efficient synthesis of 2-aminothiophenes under solvent free conditions. The three-component mixture of a carbonyl compound, malonodinitrile, and elemental sulfur was converted into the corresponding 2-aminothiophene in moderate to high yields with excellent selectivity. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Product Details of 70291-62-2).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Product Details of 70291-62-2

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Calcined Mg-Al hydrotalcite as a heterogeneous base catalyst for Gewald aminothiophene synthesis was written by Rajagopal, R.;Jyothi, T. M.;Daniel, Thomas;Srinivasan, K. V.;Rao, B. S.. And the article was included in Synthetic Communications in 2001.COA of Formula: C8H8N2S This article mentions the following:

Calcined Mg-Al hydrotalcite (Mg/Al=4) has been conveniently employed as a heterogeneous base catalyst in the synthesis of 2-amino-3-cyanothiophenes adopting a one pot Gewald aminothiophene methodol. The compounds thus prepared included 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile, 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile, 2-amino-3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene and 2-amino-4,5-dimethyl-3-thiophenecarbonitrile. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2COA of Formula: C8H8N2S).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.COA of Formula: C8H8N2S

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Solar thermochemical reactions. Part II. Synthesis of 2-aminothiophenes via Gewald reaction induced by solar thermal energy was written by Mekheimer, Ramadan Ahmed;Ameen, Mohamed Abdallah;Sadek, Kamal Usef. And the article was included in Chinese Chemical Letters in 2008.Name: 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile This article mentions the following:

Green conditions were developed for the synthesis of substituted 2-aminothiophenes employing multicomponent reactions of a ketone with active methylene nitrile and elemental sulfur induced by free solar thermal energy. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Name: 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Name: 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts