Category: 70291-62-2

TiO₂/nanoclinoptilolite as an efficient nanocatalyst in the synthesis of substituted 2-aminothiophenes was written by Javadi, Farzad;Tayebee, Reza;Bahramian, Bahram. And the article was included in Applied Organometallic Chemistry in 2017.Recommanded Product: 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile This article mentions the following:

TiO₂/nanoclinoptilolite (TiO₂/NCP) was prepared by the mediation of hexadecyltrimethylammonium (HDTMA) as surfactant and used as an effective heterogeneous nanocatalyst for the preparation of substituted 2-aminothiophenes. The modified HDTMA/NCP was impregnated with titanium(IV) chloride solution followed by calcination at 500 鎺矯 for 20 h. The obtained nanocomposite was characterized using Fourier transform IR spectroscopy, field emission SEM, inductively coupled plasma optical emission spectroscopy and X-ray diffraction. Moreover, the prepared nanocomposite had high stability and recoverability under mild and solvent-free conditions. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Recommanded Product: 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The R-C-N bond angle in and nitrile is 180鎺?which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two 锜? bond in the triple bond. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Recommanded Product: 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Combinatorial synthesis of chemical building blocks 1. Azomethines was written by Ryabukhin, Sergey V.;Panov, Dmitriy M.;Plaskon, Andrey S.;Chuprina, Alexander;Pipko, Sergey E.;Tolmachev, Andrey A.;Shivanyuk, Alexander N.. And the article was included in Molecular Diversity in 2012.Synthetic Route of C8H8N2S This article mentions the following:

128 Azomethines were synthesized through condensation of carbonyl compounds with various amines in pyridine in the presence of Me₃SiCl as promoter and water scavenger in 58-98% yield. Et₃N was added to reaction mixtures before precipitating the product with H₂O to prevent acid catalyzed hydrolysis of the C:N bond. The scope and limitation of the method are discussed. High yields and a simple setup/workup procedure make this method suitable for the combinatorial synthesis of azomethines, which are suitable as starting materials for high throughput synthesis of various combinatorial libraries. The azomethines synthesized were intermediates in a one-pot combinatorial synthesis of amines and amides. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Synthetic Route of C8H8N2S).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile carbon shifts are in the range of 115閳?25 ppm whereas in isonitriles the shifts are around 155閳?65 ppm. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Synthetic Route of C8H8N2S

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Piperazine-Grafted Magnetic Reduced Graphene Oxide (Fe₃O₄@rGO-NH) as a Reusable Heterogeneous Catalyst for Gewald Three-Component Reaction was written by Rezaei-Seresht, Esmail;Bakhshi-Noroozi, Morteza;Maleki, Behrooz. And the article was included in Polycyclic Aromatic Compounds in 2021.Application of 70291-62-2 This article mentions the following:

In recent years, interesting phys. and chem. properties of graphene oxide (GO) have led to a great deal of excitement in the chem. One of the most promising results is the use of GO and the functionalized GOs as heterogeneous catalysts in organic synthesis. In this work, GO was functionalized with piperazine (GO-NH), converted to magnetic GO-NH by incorporating Fe₃O₄ particles into GO-NH (Fe₃O₄@rGO-NH), and then reduced with hydrazine hydrate to yield piperazine-grafted magnetic reduced graphene oxide (Fe₃O₄@rGO-NH). The obtained Fe₃O₄@rGO-NH was used as a heterogeneous catalyst in the Gewald three-component reaction between some aldehydes or ketones, sulfur, and malononitrile or Et cyanoacetate. The catalyst showed good activity for various starting materials, easy separation from the reaction mixture using an ordinary magnet and reusability. Also, the catalyst was used six times without significant loss of activity. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Application of 70291-62-2).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Application of 70291-62-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

2-(Benzoylimino)thiazolidin-4-ones: formation by an alternative ring closure and analysis of rotational barriers was written by Haecker, Hans-Georg;Elsinghorst, Paul W.;Michels, Susanne;Daniels, Joerg;Schnakenburg, Gregor;Guetschow, Michael. And the article was included in Synthesis in 2009.Category: nitriles-buliding-blocks This article mentions the following:

The reactions of N-benzoyl-N’-(o-cyanoaryl)thioureas with Et bromoacetate under alk. conditions led to the formation of either fused 2-(alkylsulfanyl)-4-aminopyrimidines or 2-(benzoylimino)-3-(o-cyanoaryl)thiazolidin-4-ones. The accurate application of slightly different reaction conditions allowed us to adjust the balance between the formation of the pyrimidine or thiazolidine heterocycles. Atropisomerism in the 3-(o-cyanoaryl)thiazolidin-4-ones was influenced by the size of the o-cyanoaryl ring, which was investigated by means of NMR measurements and theor. calculations In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Category: nitriles-buliding-blocks).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ethyl 2-(3-phenylthioureido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate was written by de Oliveira, Jaismary G. B.;Mendonca, Francisco J. B. Jr.;de Lima, Maria do Carmo A.;de Simone, Carlos A.;Ellena, Javier A.. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2012.Reference of 70291-62-2 This article mentions the following:

In the title compound, C₁₇H₁₈N₂O₂S₂, the angle between the mean plane defined by the atoms of the 5,6-dihydro-4H-cyclopenta[b]thiophene moiety (root-mean-square deviation = 0.19 鑴? and the Ph ring is 72.8鎺?2). The mol. conformation is stabilized by an intramol. N-H璺矾璺疧 interaction, which generates an S(6) ring motif. In the crystal, pairs of N-H璺矾璺疭 H bonds link the mols. to form inversion dimers with an R₂²(8) ring motif. Crystallog. data and at. coordinates are given. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Reference of 70291-62-2).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Reference of 70291-62-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Facile pathway for synthesis of two efficient catalysts for preparation of 2-aminothiophenes and tetrahydrobenzo[b]pyrans was written by Saadati-Moshtaghin, Hamid Reza;Zonoz, Farrokhzad Mohammadi. And the article was included in Research on Chemical Intermediates in 2018.Recommanded Product: 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile This article mentions the following:

Abstract: We report here a new magnetically recyclable catalyst consisting of iron-substituted Keggin-type heteropolyacid (HPA) grafted on modified Fe₃O₄ nanoparticles. The synthesized hybrid nanomaterial exhibited the excellent catalytic efficiency in condensation reaction for the preparation of tetrahydrobenzo[b]pyrans under solvent-free conditions as well as in the synthesis of 2-aminothiophenes via Gewald reaction. It must be noted that, HPA supported magnetite nanoparticles catalyzed the preparation of tetrahydrobenzo[b]pyrans, whereas for Gewald reaction amine-functionalized magnetite nanoparticles acted as a catalyst. Different characterization techniques such as Fourier transform IR (FT-IR), X-ray powder diffraction (XRD), field emission SEM (FESEM), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM) were used to characterize the hybrid nanomaterial. The reusability of catalyst was affirmed by using in consecutive runs for five times. Performance of prepared catalyst was compared with the various previously reported catalysts; the newly synthesized catalysts found to be most efficient with regard to reaction time, yield and ease of catalyst separation In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Recommanded Product: 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Recommanded Product: 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

A green chemical approach: a straightforward one-pot synthesis of 2-aminothiophene derivatives via Gewald reaction in deep eutectic solvents was written by Shaabani, Ahmad;Hooshmand, Seyyed Emad;Afaridoun, Hadi. And the article was included in Monatshefte fuer Chemie in 2017.SDS of cas: 70291-62-2 This article mentions the following:

The synergic effect of choline chloride/urea as a deep eutectic solvent was investigated in the synthesis of 2-aminothiophene derivatives via a three-component cyclocondensation of a ketone or an aldehyde with activated nitriles and elemental sulfur catalyzed by NaOH as cheap and highly accessible base. The advantages of this catalytic protocol were eco-friendly, easy to set up, reusability and a simple separation and purification of products without using chromatog. in high yields at short times. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2SDS of cas: 70291-62-2).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.SDS of cas: 70291-62-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

A green chemical approach: a straightforward one-pot synthesis of 2-aminothiophene derivatives via Gewald reaction in deep eutectic solvents was written by Shaabani, Ahmad;Hooshmand, Seyyed Emad;Afaridoun, Hadi. And the article was included in Monatshefte fuer Chemie in 2017.SDS of cas: 70291-62-2 This article mentions the following:

The synergic effect of choline chloride/urea as a deep eutectic solvent was investigated in the synthesis of 2-aminothiophene derivatives via a three-component cyclocondensation of a ketone or an aldehyde with activated nitriles and elemental sulfur catalyzed by NaOH as cheap and highly accessible base. The advantages of this catalytic protocol were eco-friendly, easy to set up, reusability and a simple separation and purification of products without using chromatog. in high yields at short times. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2SDS of cas: 70291-62-2).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.SDS of cas: 70291-62-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

2-Substituted 8,9-cycloalkathieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-ones was written by Chernyuk, O. M.;Tolmachova, V. S.;Vovk, M. V.. And the article was included in Ukrainskii Khimicheskii Zhurnal (Russian Edition) in 2009.Recommanded Product: 70291-62-2 This article mentions the following:

A series of cycloalkane-fused thieno[3.2-e][1,2,4]triazolo[1,5-c]pyrimidinones I [R¹R² = (CH₂)₃, (CH₂)₄, CH₂CHMeCH₂CH₂, (CH₂)₅; R³ = Ph, 4-FC₆H₄, 2-furyl, 3-pyridyl, etc.] was synthesized by condensation of N-(cyanothienyl) carbamates II with carboxylic acids hydrazides R³CONHNH₂. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Recommanded Product: 70291-62-2).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Recommanded Product: 70291-62-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ethylene diamine grafted nanoporous UiO-66 as an efficient basic catalyst in the multi-component synthesis of 2-aminothiophenes was written by Erfaninia, N.;Tayebee, R.;Dusek, M.;Amini, M. M.. And the article was included in Applied Organometallic Chemistry in 2018.Application of 70291-62-2 This article mentions the following:

This study demonstrates ED-UiO-66 as a novel and effective solid nanoporous basic catalyst prepared through the amine grafting onto the pores of UiO-66. The manufactured nanoparticles were identified by FT-IR, XRD, TGA, FESEM, TEM, CHN and BET and the characterization results certified formation of a single phase nanoporous substance with the medium grain size less than 90 nm. The synthesized material was employed as an efficient catalyst for the preparation of 2-aminothiophenes I [R = 4,5-(-CH₂-)₅, 5-CH₃, 5-C₆H₅] through the Gewald method. This thermochem. stable nanocatalyst was environmentally safe, reusable and economic. Therefore, this methodol. can be simply extended for industrial goals. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Application of 70291-62-2).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Application of 70291-62-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts