Category: 69975-66-2

Application of 69975-66-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69975-66-2, name is 3-Oxo-indan-5-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a series of 1.5 mL glass tubes was added amine 5 or 6 in NMP (0.95 M, 0.095 mmol), followed by solutions of different indanones (0.5 M, 0.1 mmol) in NMP, and these mixtures were subsequently treated with acetic acid (0.1 mmol), followed by 5-ethyl-2-methylpyridineborane (PEMB) (0.2 mmol). The reaction mixture was heated at 65 C on a reaction block for 24 h. The reaction mixtures were purified directly using an automated mass-guided reverse phase HPLC, and product containing fractions were concentrated to give final products of >90% purity as judged by LC-MS (average of 220 and 254 nm traces).

The chemical industry reduces the impact on the environment during synthesis 3-Oxo-indan-5-carbonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Article; Vilums, Maris; Zweemer, Annelien J. M.; Barmare, Farhana; Van Der Gracht, Anouk M. F.; Bleeker, Dave C. T.; Yu, Zhiyi; De Vries, Henk; Gross, Raymond; Clemens, Jeremy; Krenitsky, Paul; Brussee, Johannes; Stamos, Dean; Saunders, John; Heitman, Laura H.; Ijzerman, Adriaan P.; European Journal of Medicinal Chemistry; vol. 93; (2015); p. 121 – 134;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 69975-66-2, name is 3-Oxo-indan-5-carbonitrile, A new synthetic method of this compound is introduced below., Computed Properties of C10H7NO

[00286] To a solution of 3-oxo-2,3-dihydro-lH-indene-5-carbonitrile (200 mg, 1.27 mmol) in acetic acid (6 mL) was added nicotinaldehyde (0.14 g, 1.27 mmol), ethyl 2-cyanoacetate (0.2 g, 1.78 mmol) and ammonium acetate (0.98 g, 12.7 mmol). The reaction mixture was heated to 80 C and stirred at that temperature for 10 min under microwave irradiation. Then the reaction mixture was cooled to RT. Water (20 mL) was added to the reaction vessel, which resulted in the formation of a precipitate. The precipitate was filtered, washed with water (3 x 5 mL), ether (3 x 5 mL) and then purified by flash column chromatography with a gradient elution of EtOAc (30%) and Hex (70%) to EtOAc (70%) and Hex (30%) to provide 2-oxo-4-(pyridin-3-yl)-2,5- dihydro-lH-indeno[l,2-b]pyridine-3,8-dicarbonitrile (20 mg, 0.06 mmol) as a yellow solid. LC/MS [M+H]+ = 311.3.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SUNOVION PHARMACEUTICALS INC.; NEWCOM, Jason, S.; SPEAR, Kerry, L.; WO2015/88564; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts