Category: 69797-49-5

Reference of 69797-49-5,Some common heterocyclic compound, 69797-49-5, name is 2-Amino-3-methylbenzonitrile, molecular formula is C8H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

b. 2-[1-Oxo-5-(2-propenyl)-2-cyclopenten-3-yl]amino3-pentylbenzonitrile (Formula II, A=formula Ia, X=>C-H, n=1, Ra=pentyl, Rb=2-propenyl) A procedure similar to that described in Example 11b was followed using the following changes and substitutions: 2-amino-3-pentylbenzonitrile (1.51 g) from Example 10e instead of the nitrile from Example 1d, and 4-(2-propenyl)-1,3-cyclopentanedione (1.30 g instead of the amount indicated in Example 11b) in toluene (10 ml instead of the amount indicated in Example 11b). Following a heating interval of 5.5 hours, excess toluene was distilled off and the residue cooled to ambient temperature. Partitioning of the residue between saturated aqueous NaHCO3 and ethyl acetate was followed by separation of the layers and washing of the ethyl acetate layer with brine. After drying and concentrating the material, the crude product was chromatographed over silica gel using ethyl acetate:hexane (1:1) as the eluent. There was obtained the title product (1.21 g, 49%) as a yellow gum; tlc, Rf =0.23, silica gel, ethyl acetate:hexane (1:1).

The synthetic route of 69797-49-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ICI Americas Inc.; US4975435; (1990); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 69797-49-5, The chemical industry reduces the impact on the environment during synthesis 69797-49-5, name is 2-Amino-3-methylbenzonitrile, I believe this compound will play a more active role in future production and life.

To a solution of 2-amino-3- methylbenzonitrile (0.85 g, 6.4 mmol) in THF (17 ml) was added triethylamine (0.99 ml, 7.1 mmol) followed by phosgene (20 % in toluene, 3.41 ml, 6.4 mmol). The RM was heated at reflux for 4 h then allowed to cool to RT. The THF was evaporated in vacuo and the residue precipitated with cold pentane. The resulting mixture was filtered and the filtrate evaporated to give the title compound as a yellow oil. Y = 74 %. MS ES+: 232.0 (compound analysed in diethylamine to generate diethyl urea).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-3-methylbenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NODTHERA LIMITED; BOCK, Mark G.; WATT, Alan Paul; PORTER, Roderick Alan; HARRISON, David; (229 pag.)WO2019/25467; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69797-49-5, name is 2-Amino-3-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2-Amino-3-methylbenzonitrile

Dissolve 2-amino-3-methylbenzonitrile (10.0g, 75.6mmol) and DMSO (7mL) in ethyl acetate (140mL), and dropwise add HBr aqueous solution (3mL) at room temperature for 30-60min. After the dropwise addition is completed, the reaction bottle is closed at 50-80 C, and the reaction time is 1-6h. After the reaction was completed, 1M potassium carbonate aqueous solution (150 mL) was added for washing, and dichloromethane (120 * 3) was used for liquid separation, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure.The target product, 2-amino-5-bromo-3-methylbenzonitrile, was obtained as a yellow solid (13.3 g, 83.1%).

According to the analysis of related databases, 69797-49-5, the application of this compound in the production field has become more and more popular.