Some common heterocyclic compound, 69316-08-1, name is Methyl 4-(cyanoacetyl)benzoate, molecular formula is C11H9NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 69316-08-1
4-(5-Amino-2H-pyrazol-3-yl)-benzoic acid methyl ester The named compound is the 3-aminopyrazole used in the reaction of Example 23 and can be prepared from commercially available 4-(2-cyano-acetyl)-benzoic acid methyl ester by the following method: 4-(2-Cyano-acetyl)-benzoic acid methyl ester (1.0 gm.) is dissolved in 9.29 mL anydrous EtOH, treated with anhydrous hydrazine (0.37 mL) and heated to reflux. The resulting reaction mixture is refluxed for 24 h, subsequently cooled to room temperature, and concentrated in vacuo to provide the named compound in the amount of 0.45 gms.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 69316-08-1, its application will become more common.
Reference:
Patent; Allergan, Inc.; US6559173; (2003); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts