Electric Literature of 67237-76-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 67237-76-7, name is Ethyl 2-(2-cyanophenyl)acetate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
In a 250 ml four-necked flask with stirring, thermometer and distillation system,23.3 g (0.1 mol) of N-phenyl-2-chloro-2-(pyridin-2-yl)ethylamine (II2) (commercially available) was added.20.5 g (0.11 mol) of ethyl 2-cyanophenylacetate, reacted at 105-110 C for 4 hours.At the same time, the removed ethanol is distilled off, and the gas phase detection reaction is completed. Cool down to 50-60 C,Add 50 g of methyl tert-butyl ether, cool to room temperature, and filter.The filter cake was washed with 20 g of methyl tert-butyl ether and dried.33.8 g of N-phenyl-N-[2-chloro-2-(pyridin-2-yl)]ethyl-2-cyanophenylacetamide (IV2) were obtained.The yield was 89.8%, and the gas phase purity was 99.6%.
The synthetic route of Ethyl 2-(2-cyanophenyl)acetate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Xin Fa Pharmaceutical Co., Ltd.; Qi Yuxin; Ju Lizhu; Zhang Mingfeng; (10 pag.)CN110028442; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts