Category: 67197-53-9

Palladium-Catalyzed Synthesis of 1H-Indenes and Phthalimides via Isocyanide Insertion was written by Wang, Xu;Xiong, Wenfang;Huang, Yubing;Zhu, Jiayi;Hu, Qiong;Wu, Wanqing;Jiang, Huanfeng. And the article was included in Organic Letters in 2017.Recommanded Product: 2-(2,6-Dibromophenyl)acetonitrile This article mentions the following:

A new and versatile multicomponent domino strategy has been developed for the synthesis of a series of 1H-indene and phthalimide derivatives from simple and readily available starting materials. This process operating under mild conditions shows a broad substrate scope with moderate to excellent yields. In the experiment, the researchers used many compounds, for example, 2-(2,6-Dibromophenyl)acetonitrile (cas: 67197-53-9Recommanded Product: 2-(2,6-Dibromophenyl)acetonitrile).

2-(2,6-Dibromophenyl)acetonitrile (cas: 67197-53-9) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C閳ユ弲 bond formation or by dehydration of primary carboxamides. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Recommanded Product: 2-(2,6-Dibromophenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

A new and practical method for the synthesis of 6-aryl-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-diones was written by Camarasa, Marta;Barnils, Christian;Puig de la Bellacasa, Raimon;Teixido, Jordi;Borrell, Jose I.. And the article was included in Molecular Diversity in 2013.Quality Control of 2-(2,6-Dibromophenyl)acetonitrile This article mentions the following:

A one step general synthetic method for the synthesis of 6-aryl-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione derivatives was described. This methodol. is based on treating a 2-aryl-substituted acrylate with a 6-amino-4(3H)-pyrimidinone derivative in the presence of a base under microwave irradiation conditions. The resulting pyrido[2,3-d]pyrimidine derivatives present an aryl substituent at position C6, precisely the one directly related to the biol. activity of such heterocyclic compounds These protocols were extended to other 2-alkyl-substituted and 3-alkyl (or aryl)-substituted acrylate derivatives but with lower yields. The synthesis of the target compounds was achieved by a reaction of 2,6-diamino-4(3H)-pyrimidinone with 浼?(methylene)benzeneacetic acid Me ester derivatives (acrylate esters), 浼?methylene-1-naphthaleneacetic acid Me ester, 2-methyl-2-propenoic acid Me ester. 6-Amino-2-(methylthio)-4(3H)-pyrimidinone was also a suitable starting material. The title compounds thus formed included 2-amino-5,8-dihydro-6-(phenyl)pyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione (I) and related substances. In the experiment, the researchers used many compounds, for example, 2-(2,6-Dibromophenyl)acetonitrile (cas: 67197-53-9Quality Control of 2-(2,6-Dibromophenyl)acetonitrile).

2-(2,6-Dibromophenyl)acetonitrile (cas: 67197-53-9) belongs to nitriles. The R-C-N bond angle in and nitrile is 180鎺?which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two 锜? bond in the triple bond. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Quality Control of 2-(2,6-Dibromophenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

A new and practical method for the synthesis of 6-aryl-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-diones was written by Camarasa, Marta;Barnils, Christian;Puig de la Bellacasa, Raimon;Teixido, Jordi;Borrell, Jose I.. And the article was included in Molecular Diversity in 2013.Quality Control of 2-(2,6-Dibromophenyl)acetonitrile This article mentions the following:

A one step general synthetic method for the synthesis of 6-aryl-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione derivatives was described. This methodol. is based on treating a 2-aryl-substituted acrylate with a 6-amino-4(3H)-pyrimidinone derivative in the presence of a base under microwave irradiation conditions. The resulting pyrido[2,3-d]pyrimidine derivatives present an aryl substituent at position C6, precisely the one directly related to the biol. activity of such heterocyclic compounds These protocols were extended to other 2-alkyl-substituted and 3-alkyl (or aryl)-substituted acrylate derivatives but with lower yields. The synthesis of the target compounds was achieved by a reaction of 2,6-diamino-4(3H)-pyrimidinone with α-(methylene)benzeneacetic acid Me ester derivatives (acrylate esters), α-methylene-1-naphthaleneacetic acid Me ester, 2-methyl-2-propenoic acid Me ester. 6-Amino-2-(methylthio)-4(3H)-pyrimidinone was also a suitable starting material. The title compounds thus formed included 2-amino-5,8-dihydro-6-(phenyl)pyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione (I) and related substances. In the experiment, the researchers used many compounds, for example, 2-(2,6-Dibromophenyl)acetonitrile (cas: 67197-53-9Quality Control of 2-(2,6-Dibromophenyl)acetonitrile).

2-(2,6-Dibromophenyl)acetonitrile (cas: 67197-53-9) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Quality Control of 2-(2,6-Dibromophenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts