Category: 6587-24-2

6587-24-2, name is Methyl 2-cyanobenzoate, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of Methyl 2-cyanobenzoate

From methyl 2-cyanobenzoate (1). To a freshly prepared solution of sodium methoxide obtained by dissolving sodium metal (0.69 g, 30 mmol) in dry MeOH (25 mL), methyl 2-cyanobenzoate (1) (1.61 g, 10 mmol) and malononitrile (1.98 g, 30 mmol) were added with stirring. The obtained yellow-orange solution was refluxed for 8 h till the TLC showed the absence of starting ester 1. Then the resulting suspension was cooled, fine pale yellow precipitate of compound 10a was filtered off, washed with MeOH (10 mL) and dried in air. Pale yellow powder. Yield: 2.00 g (68 %); mp 262-263 C.

The synthetic route of 6587-24-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tkachuk, Volodymyr; Merkulova, Vladyslava; Omelchenko; Arrault, Axelle; Hordiyenko, Olga; Tetrahedron Letters; vol. 60; 30; (2019); p. 1959 – 1963;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 6587-24-2, name is Methyl 2-cyanobenzoate, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6587-24-2, category: nitriles-buliding-blocks

3a A mixture of methyl 2-cyanobenzoate (1.0 g, 6.2 mmol) and PtO2 (100 mg) in 20 mL EtOH and 1 ml of chloroform was hydrogenated under 50 psi of hydrogen for 2 h. The reaction mixture was filtered through Celite in a sintered glass funnel and concentrated on a rotary evaporator to give methyl 2-(aminomethyl)benzoate as a HCl salt and this was carried to the next step crude.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-cyanobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sheppeck, James; US2004/67996; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 6587-24-2, The chemical industry reduces the impact on the environment during synthesis 6587-24-2, name is Methyl 2-cyanobenzoate, I believe this compound will play a more active role in future production and life.

The mixture of 3.29 gmethyl 2-cyanobenzoate 4 (20.4 mmol), 60 cm3 MeOH,and 22 cm3 1 M NaOH was stirred overnight, and thenconcentrated in vacuo. The residue was diluted with100 cm3 H2O and 100 cm3 DCM, and then acidified with22 cm3 1 M HCl under cooling. The resulting precipitatewas collected, washed with 100 cm3 H2O, 100 cm3 petroleumether and dried to afford 2.60 g (87%)2-cyanobenzoic acid 5 as a white crystalline powder. M.p.:228-230 C ([54] 227-228 C). 1H and 13C NMR spectrawere found to be identical with the ones described in [69].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-cyanobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Tkachuk, Volodymyr A.; Hordiyenko, Olga V.; Omelchenko, Irina V.; Medviediev, Volodomir V.; Arrault, Axelle; Monatshefte fur Chemie; vol. 149; 12; (2018); p. 2293 – 2309;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 6587-24-2,Some common heterocyclic compound, 6587-24-2, name is Methyl 2-cyanobenzoate, molecular formula is C9H7NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 2 2-{2-[6-Fluoro-3-(2-methyl-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-1-hydroxy-vinyl}-benzonitrile A solution of diisopropylamine (0.046 mL, 0.47 mmol) in tetrahydrofuran (2.7 mL) was chilled to -78 C. and butyllithium (0.13 mL, 0.32 mmol, 2.5 N in hexanes) was added dropwise. The solution was stirred 10 minutes and then a solution 6-fluoro-2-methyl-3-(2-methyl-pyridin-3-yl)-3H-quinazolin-4-one (0.10 g, 0.37 mmol) in tetrahydrofuran (0.7 mL) was added dropwise. The solution became intense red and was stirred 30 minutes. In a separate vessel a solution of methyl 2-cyanobenzoate (0.50 g, 3.1 mmol) in tetrahydrofuran (10 mL) was prepared and chilled to -78 C. The cold red anion solution was added to the cold methyl 2-cyanobenzoate solution via canula over 30 seconds. The resulting mixture was stirred 30 minutes at -78 C. and then quenched with saturated aqueous bicarbonate and warmed to ambient temperature. The mixture was diluted with water and repeatedly extracted with ethyl acetate. The combined extracts were washed with water and brine, dried over magnesium sulfate and concentrated. The residue was flash chromatographed on silica gel (20*100 mm) with elution proceeding as follows: 10% ethyl acetate/hexane (50 mL), nil; 20% ethyl acetate/hexane (50 mL), unweighedrecovered 3-(2-methyl-pyridin-3-yl)-6-fluoro-2-methyl-3H-quinazolin-4-one; 30% ethyl acetate/hexane (50 mL), nil; 40% ethyl acetate/hexane (50 mL), unweighed recovered methyl 2-cyanobenzoate; 50% ethyl acetate/hexane (50 mL), unweighed impurity; 60% ethyl acetate/hexane (50 mL), mixture of impurity and desired product; 70% ethyl acetate/hexane (50 mL), product. The product containing fractions were combined and concentrated. The residue was triturated with 1% ethyl acetate/ether and the yellow solid which formed was collected and dried to yield 0.017 g (10%) of 2-{2-[6-fluoro-3-(2-methyl-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-1-hydroxy-vinyl}-benzonitrile which had: mp 213-215 C.; 1 H NMR delta8.70 (d, J=4 Hz, 1 H), 7.85 (dd, J=3, 8 Hz, 1 H), 7.67 (d, J=7 Hz, 1 H), 7.60 (d, J=9 Hz, 1 H), 7.58-7.38 (m, 6 H), 4.94 (s, 1 H), 2.44 (s, 3 H). Analysis calculated for C23 H15 FN4 O2.0.25 H2 O: C, 68.57; H, 3.88; N, 13.91. Found: C, 68.52, 68,91; H, 4.13, 4.21; N, 13.25, 13.28.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-cyanobenzoate, its application will become more common.

Reference:
Patent; Pfizer Inc; US6060479; (2000); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 6587-24-2, name is Methyl 2-cyanobenzoate, molecular formula is C9H7NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 6587-24-2

To a solution of methyl 2-cyanobenzoate (322 mg, 2.0 mmol)) in MeOH (6 mL), Pd/C (10% by weight, 61 mg) and 4.0 N HCl in dioxane (0.875 mL, 1.75 eq) were added. This mixture was hydrogenated with a H2 balloon for 2.0 h. After filtration and concentration, 23A was obtained as HCl salt. 1H NMR (400 MHz, DMSO-d6) delta ppm 3.86 (s, 3 H) 4.30 (d, J=5.71 Hz, 2 H) 7.55 (m, 1 H) 7.65 (m, 2 H) 7.99 (d, J=7.91 Hz, 1 H) 8.49 (s, 3 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6587-24-2, its application will become more common.

Reference:
Patent; Bristol-Myers Squibb Company; US2007/3539; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 6587-24-2, name is Methyl 2-cyanobenzoate, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6587-24-2, Computed Properties of C9H7NO2

3a A mixture of methyl 2-cyanobenzoate (1.0 g, 6.2 mmol) and PtO2 (100 mg) in 20 mL EtOH and 1 ml of chloroform was hydrogenated under 50 psi of hydrogen for 2 h. The reaction mixture was filtered through Celite in a sintered glass funnel and concentrated on a rotary evaporator to give methyl 2-(aminomethyl)benzoate as a HCl salt and this was carried to the next step crude.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-cyanobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sheppeck, James; US2004/67996; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

6587-24-2, name is Methyl 2-cyanobenzoate, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of Methyl 2-cyanobenzoate

From methyl 2-cyanobenzoate (1). To a freshly prepared solution of sodium methoxide obtained by dissolving sodium metal (0.69 g, 30 mmol) in dry MeOH (25 mL), methyl 2-cyanobenzoate (1) (1.61 g, 10 mmol) and malononitrile (1.98 g, 30 mmol) were added with stirring. The obtained yellow-orange solution was refluxed for 8 h till the TLC showed the absence of starting ester 1. Then the resulting suspension was cooled, fine pale yellow precipitate of compound 10a was filtered off, washed with MeOH (10 mL) and dried in air. Pale yellow powder. Yield: 2.00 g (68 %); mp 262-263 C.

The synthetic route of 6587-24-2 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 6587-24-2, name is Methyl 2-cyanobenzoate, molecular formula is C9H7NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: nitriles-buliding-blocks

Methyl 2-cyanobenzoate 1 (16.10 g, 100 mmol) was dissolved with stirring in a freshly prepared solution of sodium methoxide in dry MeOH (120 mL) obtained by dissolving sodium metal (0.46 g, 20 mmol). Dry ammonia gas was bubbled with stirring through the obtained solution for 1h at 0 C. Further, ammonia gas was bubbled for an additional 2 h while heating. After standing the mixture in refrigerator overnight the resulting crystals of 3-amino-1H-isoindol-1-one 2a were filtered, washed with cold MeOH (25 mL) and dried in air. Filtrate was evaporated to 50 mL volume and cooled in refrigerator. Crystalline precipitate was filtered, washed with cold MeOH (10 mL), and dried in air to provide additional amount of title compound 2a; colorless crystals (12.85 g, 88 %), mp 203-204 C (Lit. 203-204 C [3]).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6587-24-2, its application will become more common.

Reference:
Article; Tkachuk, Volodymyr; Merkulova, Vladyslava; Omelchenko; Arrault, Axelle; Hordiyenko, Olga; Tetrahedron Letters; vol. 60; 30; (2019); p. 1959 – 1963;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts