Category: 658-98-0

Liu, Yongfu; Wu, Jun; Zhou, Mingwei; Chen, Wenming; Li, Dongbo; Wang, Zhanguo; Hornsperger, Benoit; Aebi, Johannes D.; Marki, Hans-Peter; Kuhn, Bernd; Wang, Lisha; Kuglstatter, Andreas; Benz, Jorg; Muller, Stephan; Hochstrasser, Remo; Ottaviani, Giorgio; Xin, Jian; Kirchner, Stephan; Mohr, Susanne; Verry, Philippe; Riboulet, William; Shen, Hong C.; Mayweg, Alexander V.; Amrein, Kurt; Tan, Xuefei published an article in Journal of Medicinal Chemistry. The title of the article was 《Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors》.HPLC of Formula: 658-98-0 The author mentioned the following in the article:

Aldosterone synthase (CYP11B2) inhibitors have been explored in recent years as an alternative therapeutic option to mineralocorticoid receptor (MR) antagonists to reduce elevated aldosterone levels, which are associated with deleterious effects on various organ systems including the heart, vasculature, kidney, and central nervous system (CNS). A benzamide pyridine hit derived from a focused screen was successfully developed into a series of potent and selective 3-pyridyl isoindolin-1-ones CYP11B2 inhibitors. Our systematic structure-activity relationship study enabled us to identify unique structural features that result in high selectivity against the closely homologous cortisol synthase (CYP11B1). We evaluated advanced lead mols., exemplified by compound 52, in an in vivo cynomolgus monkey acute adrenocorticotropic hormone (ACTH) challenge model and demonstrated a superior 100-fold in vivo selectivity against CYP11B1. In the part of experimental materials, we found many familiar compounds, such as 3-Chloro-4-fluorophenylacetonitrile(cas: 658-98-0HPLC of Formula: 658-98-0)

3-Chloro-4-fluorophenylacetonitrile(cas: 658-98-0) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.HPLC of Formula: 658-98-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Boltalina, Olga V.; Markov, Vitaliy Y.; Borschevskii, Andrey Y.; Davydov, Vladimir Y.; Sidorov, Lev N.; Bezmelnitsin, Valery N.; Eletskii, Alexander V.; Taylor, Roger published an article in Mendeleev Communications. The title of the article was 《Saturated vapor pressure and enthalpy of sublimation of C84》.Name: 3-Chloro-4-fluorophenylacetonitrile The author mentioned the following in the article:

The vapor pressure and sublimation enthalpy of HPLC-purified C84 have been determined by Knudsen cell mass spectrometry in the temperature range 658-980 K; the temperature-pressure equation is ln(p/Pa) = (-24337 ± 539)/(T/K) + (25.15 ± 0.64), the mean sublimation enthalpy at 853 K is 202 ± 4 kJ mol-1. After reading the article, we found that the author used 3-Chloro-4-fluorophenylacetonitrile(cas: 658-98-0Name: 3-Chloro-4-fluorophenylacetonitrile)

3-Chloro-4-fluorophenylacetonitrile(cas: 658-98-0) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Name: 3-Chloro-4-fluorophenylacetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ishichi, Yuji; Kimura, Eiji; Honda, Eiji; Yoshikawa, Masato; Nakahata, Takashi; Terao, Yasuko; Suzuki, Atsuko; Kawai, Takayuki; Arakawa, Yuuichi; Ohta, Hiroyuki; Kanzaki, Naoyuki; Nakagawa, Hideyuki; Terauchi, Jun published their research in Bioorganic & Medicinal Chemistry on August 1 ,2013. The article was titled 《Novel triple reuptake inhibitors with low risk of CAD associated liabilities: Design, synthesis and biological activities of 4-[(1S)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine and related compounds》.Product Details of 658-98-0 The article contains the following contents:

A novel triple reuptake inhibitor with low potential of liabilities associated with cationic amphiphilic drug (CAD) was identified following an anal. of existing drugs. Low mol. weight (MW < ca. 300), low aromatic ring count (number = 1) and reduced lipophilicity (C log P < 3.5) were hypothesized to be key factors to avoid the CAD associated liabilities (CYP2D6 inhibition, hERG inhibition and phospholipidosis). Based on the hypothesis, a series of piperidine compounds was designed with consideration of the common characteristic features of CNS drugs. Optimization of the side chain by adjusting overall lipophilicity suggested that incorporation of a methoxymethyl group could provide compounds with a balance of both potent reuptake inhibition and low liability potential. Compound (S)-I showed a potent antidepressant-like effect in the mice tail suspension test (MED = 10 mg/kg, p.o.), proportional monoamine transporter occupancies and enhancement of monoamine concentrations in mouse prefrontal cortex. In the experiment, the researchers used 3-Chloro-4-fluorophenylacetonitrile(cas: 658-98-0Product Details of 658-98-0)

3-Chloro-4-fluorophenylacetonitrile(cas: 658-98-0) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Product Details of 658-98-0 Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Recommanded Product: 658-98-0On September 19, 2013 ,《Dehydration Rate Measurements for tertiary-Butanol in a Variable Pressure Flow Reactor》 was published in Journal of Physical Chemistry A. The article was written by Heyne, Joshua S.; Dooley, Stephen; Dryer, Frederick L.. The article contains the following contents:

Fundamentally, the dehydration reaction of tertiary-butanol is frequently used as an internal standard for relative rate studies of other decomposition reactions. A study is reported using radical trappers to isolate this path in tertiary-butanol pyrolysis experiments conducted in the Princeton variable pressure flow reactor between 658-980 K. A novel technique that determines the rate constant value by applying a global least-squares fit incorporating all exptl. species (tertiary-butanol, isobutene, and water) evolution data is developed and applied to yield six rate constant values at two reaction pressures (6.1 and 18 atm) and at temperatures between 949-980 K. Data from previously reported studies are reanalyzed to evaluate their absolute uncertainties, and new Arrhenius parameters are derived based upon the present and previous measurements. The recommended rate constant (uncertainties) for the dehydration reaction is k = 2.88(0.91) × 107T2.21(0.10) s-1 exp-(-62.4-(0.9) kcal mol-1/RT). The new correlation is in excellent agreement with other independent exptl. and theor. studies appearing in the literature. In addition to this study using 3-Chloro-4-fluorophenylacetonitrile, there are many other studies that have used 3-Chloro-4-fluorophenylacetonitrile(cas: 658-98-0Recommanded Product: 658-98-0) was used in this study.

3-Chloro-4-fluorophenylacetonitrile(cas: 658-98-0) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Recommanded Product: 658-98-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Safety of 3-Chloro-4-fluorophenylacetonitrileOn September 25, 2008 ,《Enantiomeric Propanolamines as selective N-Methyl-D-aspartate 2B Receptor Antagonists》 was published in Journal of Medicinal Chemistry. The article was written by Tahirovic, Yesim A.; Geballe, Matthew; Gruszecka-Kowalik, Ewa; Myers, Scott J.; Lyuboslavsky, Polina; Le, Phuong; French, Adam; Irier, Hasan; Choi, Woo-baeg; Easterling, Keith; Yuan, Hongjie; Wilson, Lawrence J.; Kotloski, Robert; McNamara, James O.; Dingledine, Raymond; Liotta, Dennis C.; Traynelis, Stephen F.; Snyder, James P.. The article contains the following contents:

Enantiomeric propanolamines have been identified as a new class of NR2B-selective NMDA receptor antagonists. The most effective agents are biaryl structures, synthesized in six steps with overall yields ranging from 11-64%. The compounds are potent and selective inhibitors of NR2B-containing recombinant NMDA receptors with IC50 values between 30-100 nM. Potency is strongly controlled by substitution on both rings and the centrally located amine nitrogen. SAR anal. suggests that well-balanced polarity and chain-length factors provide the greatest inhibitory potency. Structural comparisons based on 3D shape anal. and electrostatic complementarity support this conclusion. The antagonists are neuroprotective in both in vitro and in vivo models of ischemic cell death. In addition, some compounds exhibit anticonvulsant properties. Unlike earlier generation NMDA receptor antagonists and some NR2B-selective antagonists, the present series of propanolamines does not cause increased locomotion in rodents. Thus, the NR2B-selective antagonists exhibit a range of therapeutically interesting properties. The experimental process involved the reaction of 3-Chloro-4-fluorophenylacetonitrile(cas: 658-98-0Safety of 3-Chloro-4-fluorophenylacetonitrile)

3-Chloro-4-fluorophenylacetonitrile(cas: 658-98-0) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Safety of 3-Chloro-4-fluorophenylacetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ali, Abdelselam; Bliese, Marianne; Rasmussen, Jo-Anne M.; Sargent, Roger M.; Saubern, Simon; Sawutz, David G.; Wilkie, John S.; Winkler, David A.; Winzenberg, Kevin N.; Woodgate, Ruth C. J. published an article on February 15 ,2007. The article was titled 《Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea)》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Application In Synthesis of 3-Chloro-4-fluorophenylacetonitrile The information in the text is summarized as follows:

A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives, e.g., I, were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity against these parasites. The experimental process involved the reaction of 3-Chloro-4-fluorophenylacetonitrile(cas: 658-98-0Application In Synthesis of 3-Chloro-4-fluorophenylacetonitrile)

3-Chloro-4-fluorophenylacetonitrile(cas: 658-98-0) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Application In Synthesis of 3-Chloro-4-fluorophenylacetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Water elimination rate measurements for tertiary-butanol》 were Heyne, J.; Dooley, S.; Dryer, F.. And the article was published in Chemical and Physical Processes in Combustion in 2011. Product Details of 658-98-0 The author mentioned the following in the article:

Alternatives to petroleum derived transportation fuels, particularly C4 alcs. (butanols), have been investigated increasingly over the last three years. One butanol isomer, teritary-butanol (derived from petroleum), is already used com. as a gasoline octane number enhancer. Studies of tertiary-butanol (t-butanol) combustion suggest that the water elimination channel (C4H9OH = iC4H8 + H2O) can contribute to approx. 75% of t-butanol consumption in flames [1]. A study of this key reaction has recently been performed in the Princeton Variable Pressure Flow Reactor (VPFR) using radical trappers to isolate this path in t-butanol pyrolysis experiments Radical trappers consume radicals produced in the pyrolysis sufficiently fast to preclude significant secondary radical reactions with t-butanol. Numerical experiments were conducted to estimate the appropriate radical trapper (1,3,5-trimethylbenzene) to fuel (t-butanol) molar ratios. The water elimination reaction was then studied in the temperature range of 658-980 K at 6.1 atm. The rate determination of water elimination reaction of t-butanol at each temperature was found by using a global least squares fit considering the species of water and isobutene. The resulting rates are then compared to previous exptl., computational and estimated rate currently in the literature. Anal. suggests that the water elimination reaction is faster than estimated from previous exptl. studies and occurs at a rate in good agreement with some more recent rate estimations [2].3-Chloro-4-fluorophenylacetonitrile(cas: 658-98-0Product Details of 658-98-0) was used in this study.

3-Chloro-4-fluorophenylacetonitrile(cas: 658-98-0) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Product Details of 658-98-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ali, Abdelselam; Bliese, Marianne; Rasmussen, Jo-Anne M.; Sargent, Roger M.; Saubern, Simon; Sawutz, David G.; Wilkie, John S.; Winkler, David A.; Winzenberg, Kevin N.; Woodgate, Ruth C. J. published an article on February 15 ,2007. The article was titled 《Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea)》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Application In Synthesis of 3-Chloro-4-fluorophenylacetonitrile The information in the text is summarized as follows:

A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives, e.g., I, were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity against these parasites. The experimental process involved the reaction of 3-Chloro-4-fluorophenylacetonitrile(cas: 658-98-0Application In Synthesis of 3-Chloro-4-fluorophenylacetonitrile)

3-Chloro-4-fluorophenylacetonitrile(cas: 658-98-0) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Application In Synthesis of 3-Chloro-4-fluorophenylacetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts