Category: 6575-13-9

Reference of 6575-13-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6575-13-9 name is 2,6-Dimethylbenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A 10 mL round-bottomed flask was charged with the appropriate nitrile 2 (0.50 mmol), arylboronic acid 1(0.60 mmol), CuBr2 (6 mg, 5mol%), t-BuOK (168 mg, 1.50 mmol), and t-BuOH (3.0 mL), and the mixture was stirred at r.t. until the reaction was complete (TLC). H2O (4.0 mL) was added, and the mixture was extracted with EtOAc (3 ×10 mL). The combined organic layers were washed twice with H2O,dried (Na2SO4), and concentrated to give a residue that was purified by column chromatography (silica gel, PE-EtOAc).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,6-Dimethylbenzonitrile, and friends who are interested can also refer to it.

Reference:
Article; Qiao, Yan; Li, Gaoqiang; Liu, Sha; Yangkai, Yujie; Tu, Jingxuan; Xu, Feng; Synthesis; vol. 49; 8; (2017); p. 1834 – 1838;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6575-13-9, name is 2,6-Dimethylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C9H9N

General procedure: An oven-dried, three-necked flask was sealed with septa and evacuated/backfilled with N2 three times before starting the reaction. To a mixture of 2.5M n-BuLi in hexane (35 mL, 87.6 mmol) anddry THF (20 mL), maintained at below -70 C, solution of N,N-diethyl-2,4-dimethylbenzamide (10a; 6 g, 29.2 mmol) and 3,4-dimethoxybenzonitrile (11b; 7.15 g, 43.8 mmol) in dry THF (7 mL)were added maintaining the temperature below -60 C. The reaction mixture was stirred at -78 C for 38.5 h. The reaction mixture was then warmed to room temperature and quenched with water. The precipitate was filtered off and washed with water and EtOAc to obtain 9b as an off-white solid. The filtrate was extracted with CH2Cl2, washed with water, and concentrated under reduced pressure. The EtOAc-insoluble fraction was again filtered off and washed with EtOAc to obtain 9b (6.46 g, 74%).

According to the analysis of related databases, 6575-13-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Khadka, Daulat Bikram; Woo, Hyunjung; Yang, Su Hui; Zhao, Chao; Jin, Yifeng; Le, Thanh Nguyen; Kwon, Youngjoo; Cho, Won-Jea; European Journal of Medicinal Chemistry; vol. 92; (2015); p. 583 – 607;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6575-13-9 as follows. SDS of cas: 6575-13-9

2,6-Dimethylbenzonitrile (10 g, 76.2 mmol),N-Bromosuccinimide (12.074 g, 68.6 mmol) and azobisisobutyronitrile (0.563 g, 3 mmol) were dissolved in anhydrous chloroform (241.42 mL), reacted at 65 C for 4 hours and extracted with dichloromethane After drying with anhydrous magnesium sulfate, purification was carried out by chromatography on silica gel (SiO2, n-Hexane: THF = 9: 1) to remove the side products to obtain a product.

According to the analysis of related databases, 6575-13-9, the application of this compound in the production field has become more and more popular.