Related Products of 6575-12-8,Some common heterocyclic compound, 6575-12-8, name is 2,6-Dibromobenzonitrile, molecular formula is C7H3Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
42b) 2-(2,6-Dibromophenyl)-3-{[4-(1,1-dimethylethyl)phenyl]methyl}-6-hydroxy-4(3H)-pyrimidinone; A 1 M solution of dimethylaluminium chloride in hexane (2.20 mL, 2.20 mmol) was added to a stirred mixture of 4-tert-butylbenzylamine (0.326 g, 2.00 mmol), 2,6-dibromobenzonitrile (0.587 g, 2.25 mmol) and toluene (6 mL) at room temperature. The mixture was stirred in a microwave reactor at 160 C. for 0.5 h, then cooled and the solvent removed under reduced pressure. Diethyl malonate (1.28 g, 8.00 mmol), 2-methoxyethanol (12 mL) and 4.37 M sodium methoxide in methanol (1.83 mL, 8.00 mmol) were added and the mixture refluxed under nitrogen for 18 h. After cooling, the mixture was poured into water (150 mL), washed with ether, acidified to pH 1 with 6 M aqueous hydrochloric acid, and extracted with ethyl acetate. The extracts were washed with water and brine, dried (MgSO4) and evaporated under reduced pressure. The residue was triturated with ether and the solid collected, washed with ether and dried to give the title compound (0.361 g, 37%) as a cream solid. 1H NMR (400 MHz, DMSO-d6) delta ppm 1.23 (s, 9 H) 4.86 (s, 2 H) 5.59 (s, 1 H) 6.74-6.80 (m, 2 H) 7.17-7.22 (m, 2 H) 7.43 (t, J=8.08 Hz, 1 H) 7.76 (d, J=8.08 Hz, 2 H) 11.86 (s, 1 H).
The synthetic route of 6575-12-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shaw, Antony N.; Duffy, Kevin J.; Tedesco, Rosanna; Wiggall, Kenneth; US2008/171756; (2008); A1;,
Nitrile – Wikipedia,
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