Continuously updated synthesis method about C8H6ClNO

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6575-10-6.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6575-10-6, name is 2-Chloro-6-methoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 6575-10-6

To a solution of A5.2 (334 mg, 2.0 mmol) in 10.0 mL THF was added of borane (2.0 mol/L). The mixture was heated at 90 oC for 3 h, then cooled to rt and quenched with methanol. The mixture was concentrated under vacuum, the residue was diluted with another 50 mL methanol, and then removed again. The process was repeated for four times to give the title compound (300 mg, 88%) as the crude product, which will used in next step without further purification. LC-MS: [MH]+ = 172.1

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6575-10-6.

Reference:
Patent; NOVARTIS AG; CHAN, Ho Man; FU, Xingnian; GU, Xiang-Ju Justin; HUANG, Ying; LI, Ling; MI, Yuan; QI, Wei; SENDZIK, Martin; SUN, Yongfeng; WANG, Long; YU, Zhengtian; ZHANG, Hailong; ZHANG, Ji Yue; ZHANG, Man; ZHANG, Qiong; ZHAO, Kehao; (193 pag.)WO2017/221092; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts