These common heterocyclic compound, 65610-13-1, name is 3-Fluorophthalonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H3FN2
A mixture of 3-fiuoro-l,2-cyanobenzene (2.49g), glycine ethyl ester hydrochloride(2.49g) and potassium carbonate (5.18g) in acetonitrile (25mL) was heated to reflux for24 hours. After cooling, the reaction mixture was extracted into dichloromethane, washedwith water, dried (MgSCU) and the solvent removed hi vacuo to yield crude productwhich was purified using flash chromatography to yield (2,3-dicyano-phenylamino)-acetic acid ethyl ester (840mg).A mixture of (2,3-dicyano-phenylamino)-acetic acid ethyl ester (453mg), triethylamine(0.24mL), di-tert-butyl dicarbonate (447mg) and 4-ditnethylaminopyridine (20mg) wasstirred in dichloromethane (5mL) at room temperature overnight. The reaction mixturewas then extracted into dichloromethane, washed with water, dried (MgSO4) and thesolvent removed in vacuo to yield crude product which was purified using flashchromatography to yield the title compound (606mg).
The synthetic route of 3-Fluorophthalonitrile has been constantly updated, and we look forward to future research findings.