Category: 654-01-3

Related Products of 654-01-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 654-01-3, name is 2-(2,6-Difluorophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows.

1-(2,6-Difluorophenyl)-cyclopropylnitrile STR25 4.0 g of tetrabutylamonium chloride were added to a mixture of 30.6 g (0.20 mol) of 2,6-difluorobenzyl cyanide and 150.0 g (0.80 mol) of 1,2-dibromoethane, and 150 ml of 50% strength sodium hydroxide solution were then added dropwise. Stirring was carried out for 5 hours at 60 C., after which hydrolysis was effected with ice water. The product was extracted with diethyl ether from the resulting mixture and was isolated in a conventional manner. Purification was carried out by chromatography using silica gel as the adsorbent and cyclohexane as the mobile phase. Yield: 52%; mp.: 56-58 C.; colorless crystals.

The chemical industry reduces the impact on the environment during synthesis 2-(2,6-Difluorophenyl)acetonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; BASF Aktiengesellschaft; US5371268; (1994); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 654-01-3, name is 2-(2,6-Difluorophenyl)acetonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(2,6-Difluorophenyl)acetonitrile

Example 13; Preparation of 1-(2,6-difluorophenyl)cyclopropanecarboxylic acid amide. 1-(2,6-Difluorophenyl)cyclopropanecarbonitrile was prepared as described in U.S. Pat. No. 4,859,232 by alkylation of 2,6-difluorophenylacetonitrile with 1,2-dibromoethane in 50% sodium hydroxide in the presence of catalytic amounts of tetrabutylammonium bromide (quantitative yield; GC/MS: m/z 179, RT 8.24 min.; 1H-NMR (DMSO-d6): delta 7.58-7.48 (m, 1H), 7.24-7.16 (m, 2H), 1.84-1.79 (m, 2H), 1.46-1.41 (m, 2H)).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

654-01-3, Name is 2-(2,6-Difluorophenyl)acetonitrile, 654-01-3, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

A mixture of 15.3 g (100 mmol) of 2-(2,6difluorophenyl)acetonitrile, 152.5 g (70 mL, 812 mmol) of dibromoethane, and 32.7 g (144 mmol) of Et3BnN+Cl- was isolated from moisture and carbon dioxide and vigorously stirred at 60. A solution prepared from 95 g (1430 mmol, ?84.5%) of KOH and 95 mL of water was then added dropwise; the mixture was stirred during 6 h at 60-65C, and left overnight. On the next day, the reaction mixture was extracted with t-BuOMe (3¡Á100 mL), the combined organic fractions were evaporated, and residual water was removed via azeotropic distillation with toluene. Then 60 mL of water and 40 mL of concentrated sulfuric acid were added to the obtained 1-(2,6-difluorophenyl)cyclopropanecarbonitrile, and the mixture was refluxed during 4 h. The reaction mass was cooled to ambient; the precipitate was filtered off and dried. Yield 17.82 g (90%), mp 156-157 (toluene). IR spectrum, nu, cm-1: 412 s, 772 m, 946 m, 994 m, 1048 s, 1246 m, 1270 m, 1306 m, 1324 m, 1414 m, 1468 m, 1474 m, 1504 s, 1624 m, 1666 m, 1726 s. 1 NMR spectrum (400.16 MHz, DMSO-d6), delta, ppm: 1.18 m (2H, 2eq, c-Pr), 1.58 m (2H, 2ax, c-Pr), 7.03 m (2H, 3,5H), 7.36 m (1H, C4H), 12.54 br.s (1H, OH). Mass spectrum (EI), m/z (Irel, %): 197.9 (100) [M]+, 153.0 (37) [M – COOH)]+, 133.0 (35) [M – COOH – HF]+, 127.2 (32) [2,6-F2C6H3CH2]+. Found, %: C 60.50; H 4.08. C10H8F2O2. Calculated, %: C 60.61; H 4.07.

Statistics shows that 2-(2,6-Difluorophenyl)acetonitrile is playing an increasingly important role. we look forward to future research findings about 654-01-3.

Reference:
Article; Novakov; Yablokov; Navrotskii; Mkrtchyan; Vernigora; Babushkin; Kachala; Ruchko; Russian Journal of General Chemistry; vol. 87; 2; (2017); p. 224 – 230; Zh. Obshch. Khim.; vol. 87; 2; (2017); p. 247 – 254,8;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts