Category: 646-20-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 646-20-8, name is Heptanedinitrile, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 646-20-8

Example 1 5-(5-AMINO-1H-PYRAZOL-4-YL)-PENTANENITRILE (2) To a solution of 1,5-dicyanopentane (1) (6.5 mL, 50 mmol) and ethyl formate (20 mL, 250 mmol) in dry diethyl ether (200 mL), sodium hydride (60%, 4 g. 100 mmol) was added. The re-action mixture was refluxed for four h, cooled to room temperature filtered and rinsed with ether and dried. To a solution of above obtained white solid in 80% ethanol/water was added hydrazine hydrochloride (6.29 g. 61 mmol). The reaction mixture was adjusted to pH 3 with concentrated HCl and then refluxed for 2 h, cooled to room temperature and neutralized with NaHCO3. Solvent was removed under reduced pressure and the residue was dried in vacuum. The residue was suspended in ethanol and filtered. The filtrate was concentrated, dissolved in 5% MeOH/CH2C12, filtered through a short silica gel column, rinsed with 5% MeOH/CH2C12 and concentrated to give 5-(5-amino-1H-pyrazol-4-yl)-pentanenitrile 2 as a oil. LCMS(API-ES) m/z: 164.2, 165.1 [M+H+]; 163.1 [M-H+].

According to the analysis of related databases, 646-20-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chu, Shaosong; Nie, Zhe; Perretta, Carin L.; Erickson, Philip Eugene; US2008/70893; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 646-20-8 as follows. SDS of cas: 646-20-8

Step 1: Preparation of 2-Aminocyclohex- 1-en ecarbonitrile (I-7a) To cold toluene (20 mL) was added 60% NaH (720 mg, 18.0 mmol) slowly andfollowed by a solution of 1,5-dicyanopentane (2.1 mL, 16.37 mmol) in toluene (5 mL)slowly at 0C. The resulting mixture was refluxed for 4 h and cooled to roomtemperature. The reaction mixture was quenched with ethanol (2 mL), water (20 mL) 15 and acetic acid (2 mL). The organic layer was separated and aqueous layer wasextracted with ethyl acetate (3 x 20 mL). The combined organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. Water was added to the crude residue, then filtered and washed with hexane to afford 850 mg (42%) of 2-aminocyclohex-1-enecarbonitrile () as a pale brown solid.20 1H NMR (400 MHz, CDCI3): 64.21 (5, 2H), 2.2-2.12 (m, 4H), 1.75-1.55 (m, 4H).

According to the analysis of related databases, 646-20-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; JIRICEK, Jan; KONDREDDI, Ravinder Reddy; SMITH, Paul William; WO2014/37900; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts