In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 64248-64-2 as follows. Product Details of 64248-64-2
EXAMPLE 37 N-(2-Cyano-4-fluorophenyl)-4-piperidone propylene ketal (39) A mixture of 2,5-difluorobenzonitrile (2.272 g, 16.33 mmol) and 4-piperidone propylene ketal (2.570 g, 16.34 mmol) was stirred at room temperature (11 d). The resulting mixture was diluted with dichloromethane and sodium carbonate solution and the aqueous layer was extracted with two additional portions of dichloromethane. The combined organic extracts were washed with brine and dried over Na2SO4. The solvent was removed in vacuo. PCTLC (SiO2, 6 mm, 20% EtOAc-80% hexane) afforded the title compound (39). 1H NMR (CDCl3, 400 MHz) consistent with assigned structure. FABLRMS m/e 277 g/mole (M++H, C15H17FN2O2=277 g/mole.) HPLC (Vydac; C18; diameter=4.6 mm; length=150 mm; gradient=H2O [0.1% H3PO4]-CH3CN, 95%-5%, 5%-95%, over 16 minutes, 2 ml/min flow rate) RT=7.31 min; focus=215 nm; 99.3% pure.
According to the analysis of related databases, 64248-64-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Merck & Co., Inc; Synaptic Pharmaceutical Corporation; US6376503; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts