Category: 64248-62-0

Synthetic Route of 64248-62-0, These common heterocyclic compound, 64248-62-0, name is 3,4-Difluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(2) Methyl2-[[(2R)-1-hydroxy-3-phenylpropan-2-yl]amino]-5-methyl-4-thiazole carboxylate (200 mg, 0.65 mmol) was dissolved in dimethyl acetamide (13 mL) and sodium hydride (60% in oil, 109 mg, 1.63 mmol) was added, and the mixture was stirred at 0 C. To this solution was added 3,4-difluorobenzonitrile (272 mg, 1.96 mmol), and the mixture was stirred at 0 C. for 15 minutes. To the solution was added an ammonium chloride aqueous solution and the mixture was extracted with ethyl acetate twice. The organic fraction was washed with a saturated salt solution and dried over sodium sulfate. The solvent was removed by distillation under reduced pressure and the resultant residue was purified by column chromatography to obtain methy 2-(4-cyano-2-fluoro-N-[(2R)-1-hydroxy-3-phenylpropan-2-yl]anilino)-5-methyl-4-thiazole carboxylate (119 mg, 43%) as a white solid. 1H-NMR (CDCl3) delta: 7.42-7.38 (2H, m), 7.32-7.20 (5H, m), 7.06 (1H, t, J=8.5 Hz), 5.26-5.23 (1H, brm), 4.14-4.08 (3H, m), 3.88 (3H, s), 3.12-3.10 (2H, brm), 2.61 (3H, s).

The synthetic route of 64248-62-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Teijin Pharma Limited; HOSODA, Shinnosuke; UNOKI, Gen; WATANABE, Hidekazu; SASAKI, Kosuke; SHIBATA, Jun; YOKOYAMA, Emi; HORIE, Kyohei; TAKAGI, Kenichiro; (202 pag.)US2019/31628; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 64248-62-0, name is 3,4-Difluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 64248-62-0, Recommanded Product: 64248-62-0

To THF (18 ml) was added cerium(III) chloride (2.84 g, 11.50 mmol) and the solution was purged, backfilled with nitrogen and warmed to 45 C. for 3 h. The reaction was cooled to rt and 3,4-difluorobenzonitrile (0.8 g, 5.75 mmol) was added. The solution was cooled further to -25 C. and methyl lithium/lithium bromide (1.5 M in diethyl ether, 9.59 ml, 14.38 mmol) was added slowly. The reaction was stirred at this temperature for 1 h and ammonium hydroxide solution (28% in water, 4.00 ml, 28.8 mmol) was added and the mixture was allowed to sit overnight at rt. The cerium salts were filtered off and washed with THF. The obtained THF solution was dried with MgSO4, filtered and concentrated. The product was diluted with ethyl ether and THF and HCl (4M in dioxane, 1.438 mL, 5.75 mmol) were added. The residue was concentrated, diluted with hexane and filtered affording the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4-Difluorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Clements, Matthew J.; Debenham, John S.; Hale, Jeffrey J.; Madsen-Duggan, Christian B.; Walsh, Thomas F.; US2009/239876; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 64248-62-0, name is 3,4-Difluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 64248-62-0, Recommanded Product: 3,4-Difluorobenzonitrile

Into a 1000 mL four-necked flask, 500 g of DMF was charged and 100 g of Compound A, 1 was charged13.6 g of potassium carbonate and 5 g of tetrabutylammonium bromide, warmed to 60 C.,A mixed solution of 83.9 g of compound B in 50 g of DMF was added dropwise thereto at a controlled temperature of 65 to 70 C,The addition was complete, the reaction for about 2 hours, the reaction was completed, added to 1000g of water,With hydrochloric acid to adjust the pH to 7 ~ 8, stirred for 1 hour, filtered,The solid is etherified, dried.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,4-Difluorobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu Fuding Chemical Co., Ltd.; Liu, Dongwei; Cheng, Lizhong; Chang, Qing; Dong, Hailong; Zhu, Ruiyu; Gu, Junkun; (11 pag.)CN106631896; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 64248-62-0, name is 3,4-Difluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 64248-62-0, Application In Synthesis of 3,4-Difluorobenzonitrile

The reaction flask (250 mL) containing magnetic stirring bar was charged with 1,3,5-tris((trimethylsilyl)oxy)benzene (10.28 g, 30 mmol),followed by the addition of 3,4 -difluorobenzonitrile (13.90 g, 100 mmol). The reaction flask was purged with Argon, and anhydrous DMF (100mL) was added. Anhydrous cesium fluoride (1.52 g, 10 mmol) was carefully added in one portion, the reaction flask was capped with a septumconnected to a bubbler and stirred at 120 C for 24 hours. The reaction mixture was poured in water under vigorous stirring and the resultingprecipitate was filtered off and air dried. The title product was obtained after the re-crystallization from ethanol. The product was obtainedafter filtration as a white powder (9.2 g, 63 %).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Chen, Hao; Cheng, Long; Dai, Sheng; Guo, Wei; Jiang, De-en; Jie, Kecheng; Jin, Wanqin; Liu, Gongping; Mahurin, Shannon Mark; Meyer, Harry M.; Popovs, Ilja; Wang, Song; Yang, Zhenzhen; Chem; vol. 6; 3; (2020); p. 631 – 645;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

A common compound: 64248-62-0, name is 3,4-Difluorobenzonitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 64248-62-0

A mixture of methyl (i?)-N-methyl-l-(7H-pyrrolo [2,3-Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; LI, Jinshui; JI, Jianguo; WO2012/22265; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts