Category: 64248-62-0

Application of 64248-62-0, These common heterocyclic compound, 64248-62-0, name is 3,4-Difluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Thiomorpholine (4.9 mL, 48.5 mmol) and potassium carbonate (13.4 g, 96.9 mmol) was dissolved in 50 mL DMF and the 3,4-difluorobenzenenitrile (6.7 g, 48.5 mmol) was added. Reaction heated to 100C overnight. Reaction was blown to dryness and residue was taken up in EtOAc and washed with water (2x), brine and then dried over sodium sulfate. Drying agent removed by filtration and then organics concentrated down and residue was recrystallized from hot isopropanol to give 8.74 g of 3-fluoro-4- thiomorpholinobenzonitrile as a light yellow solid. Residue can also be purified through silica gel.

The synthetic route of 64248-62-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MILLER, Marvin J.; MORASKI, Garrett; (133 pag.)WO2017/49321; (2017); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 64248-62-0, name is 3,4-Difluorobenzonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 3,4-Difluorobenzonitrile

In N, N-dimethylformamide (DMF, 40 mL)(R) -2- (4-hydroxyphenoxy) propionic acid (3.03 g, 0.02 mol) was added,Potassium carbonate (5.52 g, 0.04 mol) was added in portions,Heating to 70 C to 80 C,Continuous stirring 1h,(2.38 g, 0.02 mol) of 3,4-difluorobenzonitrile was added in portions,Continue to stir the reaction 6 ~ 7h.Cooled to room temperature,Poured into ice water (250 mL)Slowly add dilute hydrochloric acid,Adjusted to pH 4 to 5,Filter,Washed,(R) -2- [4- (4-cyano-2-fluorophenoxy) phenoxy] propionic acid as a gray solid in (R) -2- [4- (4-cyanide) Yl-2-fluorophenoxy) phenoxy] propionic acid3.26g,Yield 65.7%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; China Three Gorges University; Liu, Qixing; Zhou, Haifeng; Zhu, Rui; Chen, Lei; (9 pag.)CN106632007; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64248-62-0, name is 3,4-Difluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3,4-Difluorobenzonitrile

Example 27 20.0 g (144 mmol) of 3,4-difluoro-benzonitrile, 34.0 g (288 mmol) of benzimidazole and 49.7 g (360 mmol) of potassium carbonate in 340 ml of N-methylpyrrolidone(NMP) are stirred for 24 h at 120 C. The reaction mixture is cooled at room temperature and added water, then the precipitate is filterted off and dried. Yield 43 g (89 %).

According to the analysis of related databases, 64248-62-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; SAITO, Masatoshi; NAGASHIMA, Hideaki; (118 pag.)WO2017/178864; (2017); A1;,
Nitrile – Wikipedia,
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Application of 64248-62-0,Some common heterocyclic compound, 64248-62-0, name is 3,4-Difluorobenzonitrile, molecular formula is C7H3F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: 3,4-Difluorobenzonitrile (30 g, 0 · 22 mol) was placed in a 500 mL autoclave, and an ammonia gas of 37 · 4 g (2.2 mol) was introduced. Then, the temperature was raised to 110 C for 24 hours, sampled, and the reaction was monitored by liquid chromatography to a normalized content of 0.5%. After cooling to room temperature, pressure was added, toluene (120 mL) was added, the temperature was raised to 60 C for 0.5 h, then the temperature was lowered to 0 C, filtered, and the filter cake was mixed with water (150 mL X 3 ), filtered, and filtered cake 40. (: Vacuum drying to give 2- fluoro-4-aminobenzonitrile 27.9 g (yield 95%; purity >99%, off-white solid, melting point 70-72 C). It is 3-fluoro-4-aminobenzonitrile.

The synthetic route of 64248-62-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jinkai (Liaoning) Chemical Co., Ltd.; Yang Xiaoge; Wang Yongcan; Wang Xiuying; Jiang Zhipeng; Zhang Jinxin; Song Tongji; (13 pag.)CN109678741; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 64248-62-0,Some common heterocyclic compound, 64248-62-0, name is 3,4-Difluorobenzonitrile, molecular formula is C7H3F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: 3,4-Difluorobenzonitrile (30 g, 0 · 22 mol) was placed in a 500 mL autoclave, and an ammonia gas of 37 · 4 g (2.2 mol) was introduced. Then, the temperature was raised to 110 C for 24 hours, sampled, and the reaction was monitored by liquid chromatography to a normalized content of 0.5%. After cooling to room temperature, pressure was added, toluene (120 mL) was added, the temperature was raised to 60 C for 0.5 h, then the temperature was lowered to 0 C, filtered, and the filter cake was mixed with water (150 mL X 3 ), filtered, and filtered cake 40. (: Vacuum drying to give 2- fluoro-4-aminobenzonitrile 27.9 g (yield 95%; purity >99%, off-white solid, melting point 70-72 C). It is 3-fluoro-4-aminobenzonitrile.

The synthetic route of 64248-62-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jinkai (Liaoning) Chemical Co., Ltd.; Yang Xiaoge; Wang Yongcan; Wang Xiuying; Jiang Zhipeng; Zhang Jinxin; Song Tongji; (13 pag.)CN109678741; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 64248-62-0, name is 3,4-Difluorobenzonitrile, molecular formula is C7H3F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3,4-Difluorobenzonitrile

Pyrrole (2, 6, 6-trimethyltetrahydroindol-4-one) (1.0 g, 5.6 iranol) and 3, 4-difluorobenzonitrile (785 mg, 5.6 mmol) were dissolved in anhydrous DMF (20 mL) . To this NaH (95%, 270 mg, 11.2 mmol) was added and stirred at 50 0C for 30 min. The reaction mixture was cooled to RT and washed with H2O and EtOAc. The organic layer was dried over MgSO4. Column chromatography on silica eluting with EtOAc-hexanes (1:1) gave the product as a yellow solid (100% clean by LCMS, product M+H = 397.1) .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 64248-62-0, its application will become more common.

Reference of 64248-62-0, The chemical industry reduces the impact on the environment during synthesis 64248-62-0, name is 3,4-Difluorobenzonitrile, I believe this compound will play a more active role in future production and life.

40 mL of N,N-dimethylformamide was placed in a 250 mL four-necked flask.R-(+)-2-(4-hydroxyphenoxy)propionic acid butyl ester 34g (0.14 mol),3,4-difluorobenzonitrile 24g (0.168mol),Phase transfer catalyst 18-crown-6 0.15g, TEBA 0.15g,With stirring, 58 g (0.42 mol) of potassium carbonate was added, and a large amount of bubbles were generated;Then the temperature was raised to 85-90 C, the reaction was kept for 3 hours, and the sample was analyzed by HPLC.R-(+)-2-(4-hydroxyphenoxy)propionic acid butyl ester <0.5%, the reaction was completed.Filtration, distilling off the solvent under reduced pressure, and cooling to room temperature with 150 mL of water.The temperature is raised to 60-70 C, the mixture is completely dissolved, and the layer is allowed to stand.Wash with 100 mL of water and de-dissolve to dryness to give an oil.That is, the original drug of cyhalofop-butyl ester 49.5g, the yield: 98.9%, the content: 98.0%,Optical 97.2%. In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4-Difluorobenzonitrile, other downstream synthetic routes, hurry up and to see. Reference:
Patent; Jiangsu Zhongqi Technology Co., Ltd.; Zhang Sheng; Zhang Pu; Wang Yuchi; Chen Wen; Wang Fengyun; Hou Yuanchang; (6 pag.)CN109651140; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 64248-62-0,Some common heterocyclic compound, 64248-62-0, name is 3,4-Difluorobenzonitrile, molecular formula is C7H3F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3.6 mL (7.2 mmol) of trimethyl aluminum (2.0 M toluene solution) was dropwise added to a 10 mL of toluene containing 384 mg (7.17 mmol) of ammonium chloride at room temperature. After stirring for 1.5 hours, 1 g (7.1 mmol) of3,4-difluorobenzonitrile was added thereto and the resulting mixture was heated to EPO 85C for 9 hours. After completion of a reaction, the reaction solution was poured into100 mL of chloroform containing 200 g of silicagel and filtered off. The residue was washed with 200 mL of methanol and distillation was conducted to give 370 mg (2.36 mmol) of the title compound in a yield of 33%. [920] NMR: 1H-NMR(CD3OD) delta 7.87~7.82(1H, m), 7.72~7.7O(1H, m), 7.63~7.55(1H, m)[921] Mass(EI) 157(M++.)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4-Difluorobenzonitrile, its application will become more common.

Reference:
Patent; LG LIFE SCIENCES, LTD.; WO2006/104356; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 64248-62-0, name is 3,4-Difluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3,4-Difluorobenzonitrile

Step 1 (MM-Si):Potassium carbonate (22 g, 79.13 mmol) was added to a solution of 3-hydroxypyrrolidone hydrocloride (9.6 g, 79.12 mmol) in diemethylformamide (60 mL) and the mixture was stirredfor 15 mi 3,4-difluorobenzonitrile (10 g, 71 .94 mmol) was added and the mixture was stirred at 90C for 9 h. The reaction was cooled to room temperature and than quenched with ice water. The resulting mas was filtered and washed with water, pet ether and dried in vacuum to affordlO g (67.5%) of MM-Si as an off white solid.

The synthetic route of 3,4-Difluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PROBIODRUG AG; HEISER, Ulrich; BUCHHOLZ, Mirko; SOMMER, Robert; DEMUTH, Hans-Ulrich; WO2014/140279; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 64248-62-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 64248-62-0 as follows.

Into the 500 ml reaction flask, place 40 g (R)-2-(4-hydroxyphenoxy)propionic acid and 0.5 g ammonium bromide, and add 100 ml dimethyl formamide DMF and 50 ml toluene as solvent to dissolve it. After slowly adding potassium carbonate 70.7 g. After waiting for the reaction flask to not generate gas, add 30.5 g bromobutane. After 85 C reaction 7 hours, add 31 g 3,4-difluorobenzonitrile react for 5 h, then filtered and the filtrate, and 50 ml toluene after washing with the filtrate after the merger of the desolvation, drying the obtained cyhalofop 75.2 g, total reaction yield is 95.7%, the appearance is a white solid.

According to the analysis of related databases, 64248-62-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Jiangsu Yongkai Chemical Co., Ltd.; Jiang Yunxiang; Zhao Feisi; Dong Haitao; Chen Kuanxin; Wei Dongyu; (7 pag.)CN107253912; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts