Category: 64113-84-4

Application of 64113-84-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 64113-84-4, name is 2-Fluoro-5-methylbenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Heat a solution of 2-fluoro-5-methyl-benzonitrile (2. [0G,] 14.80 mmol) with 4- chloro-2-nitro-phenylamine (2.5g, 14.80 mmol) and lithium hydroxide monohydrate (1.24g, 29.60 mmol) in DMSO (30 ml) to 55 [C] for 14 hours. Add an additional 0.61 g (14.80 mmol) of lithium hydroxide monohydrate, and increase heating to 70 [C,] continue for another 14 hours. Cool the reaction to ambient temperature and pour into a mixture of 100 ml water and 200 ml ethyl acetate. Extract with three 200 ml portions of ethyl acetate. Combine organic layers, dry over sodium sulfate and evaporate solvent. Purify the residue via flash chromatography eluting with a step gradient starting with 90% hexanes: 10% ethyl acetate and going to 40% hexanes: 60% ethyl acetate to obtain 1.63 g [(5. 67] mmol, 38% yield) of the title compound as a red-orange amorphous solid: Mass Spectrum (m/e): 288 [(M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Fluoro-5-methylbenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ELI LILLY AND COMPANY; WO2004/14895; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 64113-84-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64113-84-4, name is 2-Fluoro-5-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 27 N-(2-Cyano-4-methylphenyl)-4-piperidone propylene ketal (29) A solution of 2-fluoro-5-methylbenzonitrile (2.76 g, 20.4 mmol) and 4-piperidone propylene ketal (3.39 g, 21.5 mmol) in DMF (50 mL) was heated in an oil bath (90 C., 20 h). The mixture was diluted with ether and sodium carbonate solution. The aqueous layer was extracted with two additional portions of ether and the combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure. PCTLC (SiO2, 6 mm, 50-0% hexane/CHCl3) afforded the title compound (29). 1H NMR (CDCl3, 400 MHz) consistent with assigned structure. FABLRMS m/e 273 g/mole (M++H, C16H20N2O2=273 g/mole.) HPLC (Vydac; C18; diameter=4.6 mm; length=150 mm; gradient=H2O [0.1% H3PO4]-CH3CN, 95%-5%, 5%-95%, over 16 minutes, 2 ml/min flow rate) RT=9.97 min; focus=215 nm; 97.8% pure.

The chemical industry reduces the impact on the environment during synthesis 2-Fluoro-5-methylbenzonitrile. I believe this compound will play a more active role in future production and life.

Reference of 64113-84-4,Some common heterocyclic compound, 64113-84-4, name is 2-Fluoro-5-methylbenzonitrile, molecular formula is C8H6FN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

a 4-fluoro-3-cyanobenzoic acid To a mixture of 2-fluoro-5-methylbenzonitrile (13.5 g, 0.1 mol), tetrabutylammonium bromide (1.61 g, 5 mmol), and ruthenium(III)chloride trihydrate (0.261 g, 1 mmol) in dichloromethane (150 mL) was added a solution of sodium hypochlorite (645 mL, 0.45 mol) which had been neutralized to pH 9 with 20% sulfuric acid. The reaction mixture was stirred and maintained at pH 9 by adding 20% sodium hydroxide solution at RT. After 3 h, the aqueous phase was separated and neutralized to pH 2 with 20% sulfuric acid and the solid which formed was filtered to give the title compound (3.4 g, 20%). mp 177-8 C. 1 H NMR (CDCl3) delta 7.35 (t, J=8.70 Hz, 1H), 8.38 (m, 1H), 8.42 (m, 1H).

The synthetic route of 64113-84-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SmithKline Beecham Corporation; US6117866; (2000); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 64113-84-4 name is 2-Fluoro-5-methylbenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 64113-84-4

Combine 4-fluoro-2-nitro-phenylamine (2.9g, 18.50 mmol), 2-fluoro-5-methyl- benzonitrile (2. 5g, 18.50 mmol) and lithium hydroxide monohydrate (2.4g, 57.20 mmol) in methyl sulfoxide (DMSO, 40 ml). Heat the resulting mixture to 55 [C] for 40 hours. Cool the reaction mixture to ambient temperature, then pour into approximately 250 ml of ice water and stir for one hour. Filter the resulting mixture and collect the precipitate. Chromatograph the solid using flash chromatography and elute with mobile phase: 90% hexanes, 5% ethyl acetate, and 5% dichloromethane to obtain 2.267g of the title compound (8.36 mmol, 45% yield) as an orange amorphous solid: Mass Spectrum [(M/E)] : 272 (M+1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Fluoro-5-methylbenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; ELI LILLY AND COMPANY; WO2004/14895; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts