Category: 63968-85-4

Jelier, Benson J. et al. published their research in Angewandte Chemie, International Edition in 2018 | CAS: 63968-85-4

2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Application of 63968-85-4

Radical Trifluoromethoxylation of Arenes Triggered by a Visible-Light-Mediated N-O Bond Redox Fragmentation was written by Jelier, Benson J.;Tripet, Pascal F.;Pietrasiak, Ewa;Franzoni, Ivan;Jeschke, Gunnar;Togni, Antonio. And the article was included in Angewandte Chemie, International Edition in 2018.Application of 63968-85-4 This article mentions the following:

A simple trifluoromethoxylation method enables non-directed functionalization of C-H bonds on a range of substrates, providing access to aryl trifluoromethyl ethers. This light-driven process is distinctly different from conventional procedures and occurs through an OCF3 radical mechanism mediated by a photoredox catalyst, which triggers an N-O bond fragmentation. The pyridinium-based trifluoromethoxylation reagent is bench-stable and provides access to synthetic diversity in lead compounds in an operationally simple manner. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4Application of 63968-85-4).

2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Application of 63968-85-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nyuchev, Alexander V. et al. published their research in Beilstein Journal of Organic Chemistry in 2020 | CAS: 63968-85-4

2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.HPLC of Formula: 63968-85-4

Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow was written by Nyuchev, Alexander V.;Wan, Ting;Cendon, Borja;Sambiagio, Carlo;Struijs, Job J. C.;Ho, Michelle;Gulias, Moises;Wang, Ying;Noe, Timothy. And the article was included in Beilstein Journal of Organic Chemistry in 2020.HPLC of Formula: 63968-85-4 This article mentions the following:

The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes, e.g., I under continuous-flow conditions is described. Application of continuous-flow microreactor technol. allowed to reduce the residence time up to 16 times in comparison to the batch procedure, while achieving similar or higher yields. In addition, the use of inorganic bases was demonstrated to increase the reaction yield under batch conditions. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4HPLC of Formula: 63968-85-4).

2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.HPLC of Formula: 63968-85-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Cao, Xian-Ting et al. published their research in RSC Advances in 2018 | CAS: 63968-85-4

2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.HPLC of Formula: 63968-85-4

A efficient protocol for the synthesis of thioamides in [DBUH][OAc] at room temperature was written by Cao, Xian-Ting;Qiao, Li;Zheng, Hui;Yang, Hui-Yong;Zhang, Peng-Fei. And the article was included in RSC Advances in 2018.HPLC of Formula: 63968-85-4 This article mentions the following:

A novel, simple and eco-friendly method to synthesize thioamides from aryl nitriles and sodium sulfide (Na2S·9H2O) catalyzed by 1,8-diazabicyclo[5,4,0]undec-7-enium acetate ([DBUH][OAc]) ionic liquid (IL) at room temperature was developed. In this reaction, readily available inorganic salt (Na2S·9H2O) served as the sulfur source and various functional groups of aryl nitriles were well tolerated at room temperature In addition, the products were easily separated from the IL which could be reused at least five times without considerable loss of its activity and applied in the green, concise synthesis of ethionamide. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4HPLC of Formula: 63968-85-4).

2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.HPLC of Formula: 63968-85-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Continuously updated synthesis method about 2-(Trifluoromethoxy)benzonitrile

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Trifluoromethoxy)benzonitrile, its application will become more common.

Reference of 63968-85-4,Some common heterocyclic compound, 63968-85-4, name is 2-(Trifluoromethoxy)benzonitrile, molecular formula is C8H4F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of2-(trifluoromethoxy)benzonitrile (0.342 mL, 1.999 mmol) and sodium borodeuteride (192mg, 4.60 mmol) in THF (10 mL) at 0 C was added over 45 mm, iodine (507 mg, 1.999mmol) as a solution in THF (4 ml). The reaction mixture was refluxed for 2 h. At thistime, it was cooled to 0 C and 6 N HC1 (2 ml) was carefully added. This mixture wasrefluxed for 30 mm. After cooling to rt, the mixture was partitioned between EtOAc (40ml) and iN NaOH (40 ml). The organic layer was washed with water (20 ml) and brine(20 ml). After drying (Na2504) and filtration, the organic layer was concentrated toafford 2-(trifluoromethoxy)dideuterobenzylammne (385 mg, 1.993 mmol, 100 % yield) asa light yellow oil. The material was impure and was used crude in the coupling step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Trifluoromethoxy)benzonitrile, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUO, Junqing; HART, Amy, C.; MACOR, John, E.; MERTZMAN, Michael, E.; PITTS, William, J.; SPERGEL, Steven, H.; WATTERSON, Scott, Hunter; ANDAPPAN MURUGAIAH SUBBAIAH, Murugaiah; CHEN, Jie; DZIERBA, Carolyn, Diane; LUO, Guanglin; SHI, Jianliang; SIT, Sing-Yuen; (428 pag.)WO2018/148626; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts