Category: 633336-81-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 633336-81-9, name is 4-(Aminomethyl)-3,5-difluorobenzonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 633336-81-9

[BOC- (S)] Aze-OH (1.14 g, 5.6 mmol) was dissolved in 45 [ML] of DMF. 4- Aminomethyl-2,6-difluorobenzonitrile (1.00 g, 5.95 mol, see Example [L] (xiv) above), [PYBOP] (3.10 g, 5.95 mmol) and DIPEA (3.95 mL, 22.7 mmol) were added and the solution was stirred at room temperature for 2 h. The solvent was evaporated and the residue was partitioned between H20 and EtOAc (75 [ML] each). The aqueous phase was extracted with 2 x 50 mL EtOAc and the combined organic phase was washed with brine and dried over [NA2S04.] Flash chromatography (Si02, EtOAc/heptane (3/1) ) yielded the sub-title compound (1.52 g, 77%) as an oil which crystallized in the refrigerator. ‘H-NMR (400 MHz; CD30D) : [8] 7.19 (m, 2H), 4.65-4. 5 (m, 3H), 3.86 (m, 1H), 3.73 (m, 1H), 2. [45-2.] 3 (m, 2H), 1.39 (s, 9H)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 633336-81-9, These common heterocyclic compound, 633336-81-9, name is 4-(Aminomethyl)-3,5-difluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 4-aminomethyl-2,6-difluorobenzonitrile (0. [876] g, 5.21 mmol; see step (vi) above) was dissolved in 50 mL of THF and di-tert-butyl dicarbonate (1.14 g, 5.22 mmol) in 10 mL of THF was added. The mixture was stirred for 3.5 h. The THF was evaporated and the residue was partitioned between water and EtOAc. The organic layer was washed three times with 0.5 M HCI and water, dried (Na2SO4) and evaporated. The product could be used without further purification. Yield: 1. 38 g (99%). [‘H] NMR (300 MHz, [CDC13)] 8 7.21 (m, 2H), 4.95 (broad, 1H), 4.43 (broad, 2H), 1.52 (s, 9H)

The synthetic route of 633336-81-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; WO2003/101957; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts