Category: 6330-25-2

Synthetic Route of 6330-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6330-25-2, name is 2-Cyano-N-methyl-acetamide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1.12 g (28.06 mmol) of sodium hydride at 60% in mineral oil are added, fractionwise, to a solution, cooled to 0-5 C., of 1.31 g (13.36 mmol) of N-methylcyanoacetamide (prepared according to 1.3) in 20 ml of anhydrous dimethylformamide. Stirring is continued at this temperature for ten minutes and then a solution of 3.55 g (4.93 mmol) of 6-chloro-2-[(pyridin-2-ylmethyl)amino]nicotinoyl fluoride in 20 ml of dimethylformamide is added. The medium is stirred overnight at ambient temperature and then 0.561 g (14.03 mmol) of sodium hydride at 60% is added fractionwise. Stirring is continued at this temperature for 1 hour minutes, and then the reaction mixture is poured onto ice and the subsequent mixture is acidified to pH 5-6 with an aqueous solution of acetic acid at 10%. The precipitate is isolated by filtration and, after drying in an oven, 3.98 g of the expected product are obtained in the form of a beige solid. MH+=344. Yield=87%. 1H NMR (DMSO-d6, 400 MHz, delta in ppm): delta 9.20 (s, <1H, very broad); 8.85 (s, 1H); 8.30 (m, 1H); 8.10-7.85 (m, 2H, broad); 7.80 (d, 1H); 7.75 (s, 1H, broad); 6.90 (d, 1H); 4.90 (s, 2H); 2.95 (s, 3H). In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Cyano-N-methyl-acetamide, other downstream synthetic routes, hurry up and to see. Reference:
Patent; SANOFI-AVENTIS; US2010/144757; (2010); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6330-25-2, name is 2-Cyano-N-methyl-acetamide, A new synthetic method of this compound is introduced below., SDS of cas: 6330-25-2

0.394 g (9.95 mmol) of sodium hydride at 60% in mineral oil is added, in small amounts, to a solution, cooled to 0-5 C., of 0.483 g (4.93 mmol) of N-methylcyanoacetamide in 7 ml of anhydrous dimethylformamide. Stirring is continued at this temperature for ten minutes and then a solution of 1.0 g (4.93 mmol) of 2-(aminoethyl)-6-chloronicotinic acid fluoride in 5 ml of dimethylformamide is added. The medium is stirred overnight at ambient temperature and then 0.197 g (4.93 mmol) of sodium hydride at 60% is added in small amounts. Stirring is continued at this temperature for 10 minutes and then 0.56 ml (9.78 mmol) of acetic acid is added. 60 ml of water are then added and the solid is spin-filter-dried, rinsed with water, and then dried in an oven. 1.30 g of the expected product are obtained. Melting point: 283-284 C. MH+=281. Yield=94%. 1H NMR (DMSO-d6, 400 MHz): delta 11.75 (s, <1H, very broad); 11.00 (q, 1H, broad); 8.45 (d, 1H); 8.10 (s, 1H broad); 7.40 (d, 1H); 4.40 (q, 2H); 2.80 (d, 3H); 1.25 (t, 3H). The synthetic route of 6330-25-2 has been constantly updated, and we look forward to future research findings. Reference:
Patent; SANOFI-AVENTIS; US2010/144757; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6330-25-2, name is 2-Cyano-N-methyl-acetamide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 2-Cyano-N-methyl-acetamide

After 32.03 parts of phthalonitrile were added to 224.21 parts of formamide and stirred, 39.0 parts of sodium hydroxide was added and the mixture was stirred at 50 C. for 1 hour.320 parts of water and 25.75 parts of 2-cyano-N-methylacetamide were added, and the mixture was stirred at 50 C. for 2 hours. Next, 640 parts of 80% acetic acid and 36.82 parts of barbituric acid were added, and the mixture was stirred at 90 C. for 3 hours. After cooling to 80 C., the non-volatile components were filtered off with a Buchner funnel and washed with 3000 parts of water.

The synthetic route of 6330-25-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Toyo Ink Mfg. Co., Ltd.; Aikyo, Sumihiro; Nishida, Kazufumi; (40 pag.)JP2020/26503; (2020); A;,
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6330-25-2, name is 2-Cyano-N-methyl-acetamide, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C4H6N2O

Step 3To a 10 ml seal tube was added 5-(7-pivaloyl-5-((2-trimethylsilyl)ethoxy)methyl)-5H- pyrrolo[2,3-b]pyrazin-2-ylamino)thiophene-2-carbaldehyde (0.150 g, 0.000327mole), 2-cyano – N,N- dimefhylacetamide (0.183 g, 0.00163 mole) and ethanol (5 ml) followed by addition of piperidine acetate (3.3 M solution in water) (1.5 ml, 0.00495 mole) at RT. The tube was sealed and the reaction mixture was heated at 80 C for 24 hr. After completion of reaction, ethanol was distilled out, the reaction mixture was diluted with ethyl acetate. The organic layer was separated and washed with water, dried over sodium sulphate and concentrated to give the desired crude product which was purified using column purification by eluting the compound with 35% ethyl acetate in hexane to yield 1 10 mg of 2-cyano-N,N-dimethyl-3-(5-(7-pivaloyl-5-((2- trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)thiophen-2-yl)acrylamide

The synthetic route of 6330-25-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PRINCIPIA BIOPHARMA INC.; GOLDSTEIN, David Michael; BRAMELD, Kenneth Albert; VERNER, Erik; WO2012/158785; (2012); A1;,
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Related Products of 6330-25-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6330-25-2 name is 2-Cyano-N-methyl-acetamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

9.6: 7-Amino-2-chloro-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic Acid Methylamide; In a 250 ml round-bottomed flask, under a nitrogen atmosphere, 1.3 g (33.0 mmol) of NaH at 60% are suspended in 35 ml of anhydrous DMF. The temperature of the mixture is reduced to 0 C. by means of an ice bath. 1.6 g (16.5 mmol) of 2-cyano-N-methylacetamide are added and the mixture is then stirred for 15 min at 0 C. and 1 h at ambient temperature. The temperature of the mixture is reduced to 0 C. by means of an ice bath, before said mixture is added dropwise to a solution, at 0 C., of 3.2 g (15.8 mmol) of the compound of stage 9.5 dissolved in 35 ml of DMF. The mixture is stirred for 2 hours at ambient temperature and then 660 mg (16.5 mmol) of NaH at 60% are added. The stirring of the mixture is continued for 2 h at ambient temperature and then the mixture is poured into ice-cold water (50 ml) and the DMF is evaporated off under reduced pressure. The precipitate formed is filtered off and washed with water (2×25 ml) and the resulting product is dried in an oven, so as to obtain 2.3 g (8.4 mmol) of compound in the form of a white powder. Yield=53%. 1H NMR DMSO d6 (300 MHz): 1.23 (t, J=7.1 Hz, 3H); 2.80 (d, J=4.7 Hz, 3H); 4.34 (q, J=7.1 Hz, 2H); 8.42 (bs, 1H); 9.11 (s, 1H); 10.71 (d, J=4.7 Hz, 1H); 11.96 (bs, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Cyano-N-methyl-acetamide, and friends who are interested can also refer to it.

Reference:
Patent; SANOFI-AVENTIS; US2011/251194; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 6330-25-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6330-25-2, name is 2-Cyano-N-methyl-acetamide, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Pyridine was added dropwise with stirring to cyanoacetamide 2a-e(15 mmol) in a round-bottom flask until complete dissolution of the cyanoacetamide. DMAP (18 mg, 0.15 mmol) and mercaptoacetic acid (3.2 ml, 46mmol) were added to the obtained solution. The obtained mixture was refluxed for 12 h in a flask equipped with a reflux condenser,then diluted with 0.5 HCl solution (5 ml).The precipitate of 1,3-thiazolidinone 1 was filtered off and washed with hot MeCN (15 ml). When necessary, the product was additionally purified by refluxing a suspension of thiazolidine in MeCN, followed by hot filtration.(2Z)-N-Methyl-2-(4-oxo-1,3-thiazolidin-2-ylidene)acetamide (1a). Yield 1.37 g (53%), white powder, mp 238-243(decomp.). IR spectrum, nu, cm-1: 1184, 1299, 1398,1415, 1470, 1556 (C=), 1624 (C=O), 1699 (C=O), 3312 (NH). 1H NMR spectrum, delta, ppm (J, Hz): 2.58 (3H, d, J= 4.8, CH3); 3.61 (2H, s, CH2); 5.55 (1H, s, CH); 7.61 (1H, br. s, NH); 11.20 (1H, s, NH). 13C NMR spectrum, delta, ppm: 25.3; 31.9; 92.4; 151.4; 167.0; 174.0. Mass spectrum, m/z(Irel, %): 172 []+(94), 142 [-NHCH3]+(100), 114 [-NHCH3-CO]+(55), 98 (30), 86 (37), 68 (78), 42 (35), 40 (22). Found, %: C 41.70; H 4.61; N 16.51. C6H8N2O2S. Calculated, %: C 41.85; H 4.68; N 16.27

The chemical industry reduces the impact on the environment during synthesis 2-Cyano-N-methyl-acetamide. I believe this compound will play a more active role in future production and life.

Reference:
Article; Obydennov, Konstantin L.; Galushchinskiy, Aleksei N.; Kosterina, Marya F.; Glukhareva, Tatiana V.; Morzherin, Yuri Yu.; Chemistry of Heterocyclic Compounds; vol. 53; 5; (2017); p. 622 – 625; Khim. Geterotsikl. Soedin.; vol. 53; 5; (2017); p. 622 – 625,4;,
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Nitriles – Chemistry LibreTexts

Application of 6330-25-2, These common heterocyclic compound, 6330-25-2, name is 2-Cyano-N-methyl-acetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N -Methyl 2-amino-5-(2-(4-methoxyphenyl)ethyl)thiophene-3-carboxamide (TJ19). To a mixture of 4-(4-methoxyphenyl)butanal 6 (0.5 g, 2.805 mmol), 2-cyano-N- methylacetamide 8 (0.275 g, 2.805 mmol) and sulfur (0.090g, 2.805 mmol) in DMF (10 mL), NEt3(0.851 g, 8.451 mmol, 3 equiv) was added. After stirring the resulting mixture at 60C for 30 hrs, the reaction mixture was added to water (20 mL). Ethyl acetate (20 mL) was added and the organic solution was washed with distilled water (3 chi 20 mL), dried over MgS04, filtered, and then evaporated to dryness to afford the crude product mixture. Purification by column chromatography (silica, eluent CH2CI2- ethyl acetate 90-10) afforded TJ19 (0.27 g, 33%) as an off-white solid. 1H NMR (300 MHz, CDCI3) deltaEta 2.86 (m, 7H); 3.78(s, 3H); 5.57 (s, 2H); 6.64(s, 1 H); 6.81 (d, 2H); 7.06(d, 2H).

Statistics shows that 2-Cyano-N-methyl-acetamide is playing an increasingly important role. we look forward to future research findings about 6330-25-2.

Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; UNIVERSITA DEGLI STUDI DI FERRARA; BALZARINI, Jan; DEHAEN, Wim; THOMAS, Joice; LIEKENS, Sandra; ROMAGNOLI, Romeo; BARALDI, Pier Giovanni; WO2013/190137; (2013); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 6330-25-2, name is 2-Cyano-N-methyl-acetamide, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6330-25-2, Recommanded Product: 6330-25-2

General procedure: Sodium metal (46 mg, 2.0 mmol) was placed in a flask, equipped with reflux condenser and calcium chloride tube,and dissolved in absolute ethanol (4-5 ml). The obtained solution was treated with a mixture of the appropriate 3-carbamoylchromone 3 (1 mmol) and cyanoacetamide(2 mmol) and refluxed with stirring for 2 h. After coolingthe reaction mixture to room temperature, regardless of the presence of precipitate, the mixture was stirred and neutralized with 1 N HCl. The obtained fine crystalline precipitate was filtered off, washed with ethanol, dried, and recrystallized from a 1:3 mixture of DMF-EtOH.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Cyano-N-methyl-acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kornev, Mikhail Yu.; Moshkin, Vladimir S.; Sosnovskikh, Vyacheslav Ya.; Chemistry of Heterocyclic Compounds; vol. 51; 7; (2015); p. 688 – 690; Khim. Geterotsikl. Soedin.; vol. 51; 7; (2015); p. 688 – 690,3;,
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Application of 6330-25-2, A common heterocyclic compound, 6330-25-2, name is 2-Cyano-N-methyl-acetamide, molecular formula is C4H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The 1-methyl-3-cyano-4-methyl-6-hydroxy-2-pyridone required as intermediate may be prepared, for instance, by condensation of methyl acetoacetate with N-methyl-cyanoacetamide in an aqueous alkaline medium at room temperature. It constitutes a colorless powder melting at 280 to 282.

The synthetic route of 6330-25-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Cassella Farbwerke Mainkur Aktiengesellschaft; US3957749; (1976); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

6330-25-2, name is 2-Cyano-N-methyl-acetamide, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 2-Cyano-N-methyl-acetamide

General procedure: 4-Amino-7-X-8-bromo-N-(alkyl)-cinnoline-3-carboxamide (X = H or F).To a solution of 2-[(3-X-2-bromophenyl)-hydrazono]-N-(alkyl)-2-cyanoacetamide (1.0 equiv) in anhydrous toluene (0.1 M, 1 volume) was added aluminum chloride (3.0 equiv). The reaction was heated with vigorous stirring at 70-90 C for 1-3 h, cooled, and quenched with Rochelle’s salt (saturated aqueous potassium sodium tartrate, 0.5 volume). Afterward, the mixture was stirred at room temperature overnight. The aqueous layer was separated, and the organic layer was treated with fresh Rochelle’ salt (0.5 volume) while stirring at room temperature for 1 h. After separating the resulting layers, the organic suspension was washed with water and filtered to give give a tan solid. Additionally, the organic filtrate was concentrated, and triturated with ether to give a tan precipitate. The resulting solids were filtered to give a tan solid in 30-70% yield of crude product. The combined tan solid was dried at 50 C under high-vacuum to give the title compound, which was used without further purification.The intermediate compounds were prepared as follows:2-[(3-X-2-Bromophenyl)-hydrazono]-N-(alkyl)-2-cyanoacetamide (X = H or F).Solution A: To a mechanically stirred solution of 3-X-2-bromoaniline (1.0 equiv) in acetic acid (2 M, 1 volume) was added water (0.6 volume) at ambient temperature. The mixture was cooled to 0 C, and then concentrated aqueous HCl (0.5 volume) added. A precipitate was formed immediately and the suspension was stirred at 0 C for 20 min. To this suspension was added dropwise a solution of sodium nitrite (1.10 equiv) in water (0.6 volume), maintaining the internal temperature below 5 C. The resulting clear orange solution was stirred at 0 C for another 30 min.Solution B: To a mechanically stirred solution of N-(alkyl)-2-cyanoacetamide (1.25 equiv) in ethanol (4.5 volume) was added a solution of sodium acetate (1.60 equiv) in water (120 volume), and chilled to between 0 C and -5 C.Solution A was poured into solution B, maintaining the internal temperature below 0 C. An orange precipitate was formed gradually. The mixture was stirred below 0 C overnight, and then the orange precipitate was collected by filtration, washed with water (100 mL ¡Á 3), and dried at 50 C under high vacuum to remove water. An orange solid was obtained in greater than 95% yield, which was the ‘E’, and used for the next step without further purification.

The synthetic route of 6330-25-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Alhambra, Cristobal; Becker, Chris; Blake, Timothy; Chang, Amy; Damewood Jr., James R.; Daniels, Thalia; Dembofsky, Bruce T.; Gurley, David A.; Hall, James E.; Herzog, Keith J.; Horchler, Carey L.; Ohnmacht, Cyrus J.; Schmiesing, Richard Jon; Dudley, Adam; Ribadeneira, Maria D.; Knappenberger, Katherine S.; MacIag, Carla; Stein, Mark M.; Chopra, Maninder; Liu, Xiaodong F.; Christian, Edward P.; Arriza, Jeffrey L.; Chapdelaine, Marc J.; Bioorganic and Medicinal Chemistry; vol. 19; 9; (2011); p. 2927 – 2938;,
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