Category: 628-20-6

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 628-20-6, name is 4-Chlorobutyronitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 4-Chlorobutyronitrile

A solution of 4-chlorobutyronitrile (2.5 mmol) in dimethylformamide (1 mL) was added during 1.5h to a mixture of the arylamine (2.5 mmol), Cs2CO3 (2.5 mmol) and KI (5 mmol) in dimethylformamide (4 mL). The mixture was stirred at the indicated temperature and time. After completion of the reaction, as indicated by TLC, the mixture was treated with ethyl ether (50 mL) and water (10 mL). The aqueous phase was separated and extracted with ethyl ether (30 mL). The combined organic layers were dried over anhydrous sodium sulphate and filtered. The solvent was evaporated in vacuo. The crude product was purified by column chromatography (Silica gel, hexane:DCM).

The synthetic route of 628-20-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Diaz, Jimena E.; Bisceglia, Juan A.; Mollo, Ma. Cruz; Orelli, Liliana R.; Tetrahedron Letters; vol. 52; 16; (2011); p. 1895 – 1897;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 628-20-6, name is 4-Chlorobutyronitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 628-20-6, category: nitriles-buliding-blocks

A solution of 4-chlorobutyronitrile (2.5 mmol) in dimethylformamide (1 mL) was added during 1.5h to a mixture of the arylamine (2.5 mmol), Cs2CO3 (2.5 mmol) and KI (5 mmol) in dimethylformamide (4 mL). The mixture was stirred at the indicated temperature and time. After completion of the reaction, as indicated by TLC, the mixture was treated with ethyl ether (50 mL) and water (10 mL). The aqueous phase was separated and extracted with ethyl ether (30 mL). The combined organic layers were dried over anhydrous sodium sulphate and filtered. The solvent was evaporated in vacuo. The crude product was purified by column chromatography (Silica gel, hexane:DCM).

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Electric Literature of 628-20-6, A common heterocyclic compound, 628-20-6, name is 4-Chlorobutyronitrile, molecular formula is C4H6ClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of the corresponding omega-halonitrile (2.5 mmol) in dimethylformamide (0.5 ml)was added over 1.5 h to a mixture of the arylamine (5 mmol), K2CO3 (345.5 mg, 2.5 mmol)and KI (830 mg, 5 mmol) in dimethylformamide (3 ml) for compounds 1 or dimethylformamide(0.6 ml) and dimethoxyethane (2.4 ml) for compounds 4. The mixture wasstirred at the indicated temperature for 5 h. After completion of the reaction, as indicatedby TLC, the mixture was diluted with ethyl ether (50 ml) and water (10 ml). The aqueousphase was separated and additionally extracted once with ethyl ether (30 ml). The combinedorganic layers were washed with water, dried over anhydrous sodium sulfate andfiltered. The filtrate was evaporated in vacuo and the resulting crude material was dissolvedin tetrahydrofuran and treated with 1M borane/THF (30 ml). The solution was refluxedfor 2 h, cooled and treated with methanol. The solvent was then evaporated in vacuo.The residue was refluxed with 10% hydrochloric acid (30 ml) for 2 h, filtered and madealkaline with 10% aqueous sodium hydroxide. The alkaline mixture was extracted withethyl acetate (4 × 20 ml). The organic phase was washed with water (5 ml), dried oversodium sulfate and filtered. The solvent was evaporated in vacuo and the crude product waspurified by column chromatography (silica gel, dichloromethane:methanol:isopropylamine10:1:0.1).

The synthetic route of 628-20-6 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 628-20-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 628-20-6, name is 4-Chlorobutyronitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 41 5-(3-Chloropropyl)Tetrazole A mixture of 3.5 g of 4-chlorobutyronitrile, 2.3 g of sodium azide and 1.9 g of ammonium chloride in 50 ml of dimethylformamide is stirred at 140 C. for 20 hours. The reaction mixture is poured onto ice, basified with 1N sodium hydroxide and extracted twice with ethyl acetate. The aqueous fraction is acidified with acetic acid and extracted with ethylacetate. Evaporation of the ethyl acetate gives 5-(3-chloropropyl)tetrazole which is used directly in the next step.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chlorobutyronitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Rhone-Poulenc Rorer Pharmaceuticals Inc.; US5051427; (1991); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 628-20-6 as follows. category: nitriles-buliding-blocks

4-chloro-nitrile (103.5mg, 1.0mmol, 5.0equiv. ) And Na 2 S 2 O 3 ¡¤ 5H 2 O (248.2mg, 1.0mmol, 5.0equiv. After) was added to the reaction tube, followed by addition of the reaction solvent of ethanol / water (0.25mL / 0.5mL), and stirred at a reaction temperature of 100 C for 2 hours. Then the reaction system was cooled, the solvent was removed under reduced pressure, followed by addition of Sodium trifluoromethylbenzene (46.5mg, 0.2mmol, 1.0equiv.), Then added to the reaction solvent, 1,4-dioxane ring (1.0mL), and stirred at a reaction temperature of 110 C for 11 hours. The reaction solution was cooled to room temperature. Methylbenzoate was then added triphenylphosphine (36.5mg, 0.12mmol, 0.6equiv.), Stirred at room temperature for 4 hours, the reaction solution under reduced pressure and finally the solvent removed to give product 20 after column chromatography (elution agent polarity: stone ether / ethyl acetate 40:1). Yield: 62%

According to the analysis of related databases, 628-20-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; East China Normal University; JIANG, XUEFENG; XIAO, XIAO; FENG, MINGHAO; (30 pag.)CN104387303; (2016); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 628-20-6, name is 4-Chlorobutyronitrile, A new synthetic method of this compound is introduced below., Product Details of 628-20-6

Stage A 4-(N,N-Dimethylamino)butyronitrile 420 g of dimethylamine are added to a solution, heated to 80 C., of 400 g of 4-chlorobutyronitrile in 1,200 ml of pure ethanol After 12 hours under reflux, the solvent is concentrated, 3 liters of ethyl ether are then added and the precipitate formed is removed The filtrate is concentrated and distilled at 12 mm Hg. Proton nuclear magnetic resonance spectrum (200 MHz, solvent CDCl3): 1.75 ppm,q,2H; 2.25 ppm,s,6H; 2.3-2.5 ppm,t+t,2H+2H

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Adir et Compagnie; US5077288; (1991); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 628-20-6,Some common heterocyclic compound, 628-20-6, name is 4-Chlorobutyronitrile, molecular formula is C4H6ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixtureof aziridine 1 (0.25 mmol), nitrile 2 or 4 (0.25 mmol) and perchloric acid(0.25 mmol) was placed in a mortar. The reaction mixture was thoroughlyground at room temperature for 5 min. After completion (TLC) the reactionmixture was diluted with a 1 : 1 water/ethyl acetate mixture (10 ml) andwashed with sodium bicarbonate (10 ml) followed by brine solution (10 ml).Then the combined organic layer was dried over anhydrous Na2SO4.Evaporation of solvent furnished the crude product which was subjectedto column chromatography using ethyl acetate-light petroleum as eluentto obtain the analytically pure product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Chlorobutyronitrile, its application will become more common.

Reference:
Article; Charushin, Valery N.; Chupakhin, Oleg N.; De, Aramita; Kopchuk, Dmitry S.; Kovalev, Igor S.; Majee, Adinath; Santra, Sougata; Zyryanov, Grigory V.; Mendeleev Communications; vol. 30; 2; (2020); p. 188 – 189;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 628-20-6, name is 4-Chlorobutyronitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 4-Chlorobutyronitrile

1L three-necked flask 600ml of anhydrous ethanol under ice four hours continuously fed ammonia to saturation;pressurized cylinders ethanol was added a saturated solution of ammonia had been prepared, and then added 103.5g 4-chlorobutyronitrile (lmol), sealed in an oil bath heated 100-120 C, 10 hours;After completion of the reaction, cooled to room temperature, the reaction solution was spin to 70% ethanol, the precipitated solid was filtered, and the mother liquor was recrystallized with ether to give a solid, solids were combined to give a pale yellow solid drying 89.2g,No. HHC-014-A, Yield 74%

The synthetic route of 4-Chlorobutyronitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Pharmatechs Co., Ltd; Zhang, Xiaowen; Yang, Jie; (5 pag.)CN103435617; (2016); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

628-20-6, name is 4-Chlorobutyronitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 628-20-6

General procedure: A solution of the corresponding precursor (4-chlorobutyronitrile for compounds 1, 5-chlorovaleronitrile for compounds 3 and 6-bromohexanenitrile for compounds 6) (2.5 mmol) in dimethylformamide (1 mL) was added during 1.5 h to a mixture of the arylamine (2.5 mmol), Cs2CO3(2.5 mmol) and KI (5 mmol) in dimethylformamide (2.5mL). The mixture was stirred at the indicated temperature and time. After completion of the reaction, as indicated by TLC, the mixture was treated with ethyl ether (50 mL) and water (10 mL). The aqueous phase was separated and extracted with ethyl ether (30 mL). The combined organic layers were dried over anhydrous sodium sulfate and filtered. The solvent was evaporated in vacuo. The crude product was purified by column chromatography (silica gel, hexane:DCM).

The synthetic route of 628-20-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Diaz, Jimena E.; Mollo, Maria C.; Orelli, Liliana R.; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2026 – 2031;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 628-20-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 628-20-6, name is 4-Chlorobutyronitrile, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 1 Preparation of cyclopropylnitrile (2 molar scale) STR2 A stirred mixture of 4-chlorobutyronitrile (213.4 g, 2.0 mole), sodium chloride (58.0 g, 0.5 mole) and 2.0 g of water in 200 g of dimethylsulfoxide is heated to 80 C., treated with ground solid sodium hydroxide (88 g, 2.2 mole) over a 3 hour period and held at 80 C. for about 1 additional hour. The reaction mixture is cooled to room temperature neutralized to about pH6.8 with concentrated HCl (37% aqueous solution), diluted with 200 ml water (readjusted pH to 6.8 with 37% HCl) and azeotropically distilled with a Dean Stark trap to remove the cyclopropylnitrile/water azeotrope. The aqueous layer is continuously returned to the distillation pot to give the initial product as the distillate cyclopropylnitrile, 133.5 g. A 121.5 g sample of this cyclopropylnitrile is azeotropically distilled using a Dean Stark trap (to remove water) and continuous return of the organic layer to give the final productproduct cyclopropylnitrile, 106.6. g, 87.8% yield, 98% pure by GLC analysis and 0.04% H2 O by Karl Fischer titration.

The chemical industry reduces the impact on the environment during synthesis 4-Chlorobutyronitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; American Cyanamid Company; US5380911; (1995); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts