9-Sep-21 News Analyzing the synthesis route of 628-20-6

The synthetic route of 628-20-6 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 628-20-6, name is 4-Chlorobutyronitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 4-Chlorobutyronitrile

A solution of 4-chlorobutyronitrile (2.5 mmol) in dimethylformamide (1 mL) was added during 1.5h to a mixture of the arylamine (2.5 mmol), Cs2CO3 (2.5 mmol) and KI (5 mmol) in dimethylformamide (4 mL). The mixture was stirred at the indicated temperature and time. After completion of the reaction, as indicated by TLC, the mixture was treated with ethyl ether (50 mL) and water (10 mL). The aqueous phase was separated and extracted with ethyl ether (30 mL). The combined organic layers were dried over anhydrous sodium sulphate and filtered. The solvent was evaporated in vacuo. The crude product was purified by column chromatography (Silica gel, hexane:DCM).

The synthetic route of 628-20-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Diaz, Jimena E.; Bisceglia, Juan A.; Mollo, Ma. Cruz; Orelli, Liliana R.; Tetrahedron Letters; vol. 52; 16; (2011); p. 1895 – 1897;,
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Application of 628-20-6

According to the analysis of related databases, 628-20-6, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 628-20-6 as follows. Recommanded Product: 628-20-6

General procedure: To a solution of 4-dimethylaminopyridine (2 g, 0.0163 mol) in 20 mL of toluene, was added the appropriate alkyl halide (1.1 eq) at room temperature. The mixture was placed in a closed vessel and exposed to ultrasound irradiation for 5 h at 80 C using a sonication bath. The completion of the reaction was marked by the separation of oil or a solid from the initially obtained clear and homogenous mixture of 4-dimethylaminopyridine and alkyl halide in toluene. The product was isolated by extraction or filtration to remove the unreacted starting materials and solvent. Subsequently, the pyridinium IL was washed with (3 × 20 mL) of ethyl acetate followed by drying under reduced pressure.

According to the analysis of related databases, 628-20-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Messali, Mouslim; Molecules; vol. 20; 8; (2015); p. 14936 – 14949;,
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The important role of 628-20-6

According to the analysis of related databases, 628-20-6, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 628-20-6, name is 4-Chlorobutyronitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 628-20-6

A solution of 4-chlorobutyronitrile (2.5 mmol) in dimethylformamide (1 mL) was added during 1.5h to a mixture of the arylamine (2.5 mmol), Cs2CO3 (2.5 mmol) and KI (5 mmol) in dimethylformamide (4 mL). The mixture was stirred at the indicated temperature and time. After completion of the reaction, as indicated by TLC, the mixture was treated with ethyl ether (50 mL) and water (10 mL). The aqueous phase was separated and extracted with ethyl ether (30 mL). The combined organic layers were dried over anhydrous sodium sulphate and filtered. The solvent was evaporated in vacuo. The crude product was purified by column chromatography (Silica gel, hexane:DCM).

According to the analysis of related databases, 628-20-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Diaz, Jimena E.; Bisceglia, Juan A.; Mollo, Ma. Cruz; Orelli, Liliana R.; Tetrahedron Letters; vol. 52; 16; (2011); p. 1895 – 1897;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The important role of 628-20-6

According to the analysis of related databases, 628-20-6, the application of this compound in the production field has become more and more popular.

Electric Literature of 628-20-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 628-20-6 as follows.

EXAMPLE 27 5-(3-CHLOROPROPYL)TETRAZOLE A mixture of 4-chlorobutyronitrile, (0.05 mol) sodium azide (0.20 mol) and anhydrous aluminum chloride (0.05 mol) in 100 ml of dry tetrahydrofuran is refluxed for 24 hours. After cooling to ambient temperature the reaction is acidified with 75 ml of 15% hydrochloric acid while the hydrazoic acid generated is removed by means of an aspirator. The organic and aqueous layers are then separated and the aqueous layer extracted with ethylacetate. The combined organic extracts are dried (magnesium sulfate) and evaporated to give 5-(3-chloropropyl)tetrazole which is used directly in the next step.

According to the analysis of related databases, 628-20-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Rhone-Poulenc Rorer Pharmaceuticals Inc.; US5166210; (1992); A;,
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The origin of a common compound about C4H6ClN

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chlorobutyronitrile, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 628-20-6, The chemical industry reduces the impact on the environment during synthesis 628-20-6, name is 4-Chlorobutyronitrile, I believe this compound will play a more active role in future production and life.

General procedure: A solution of the corresponding precursor (4-chlorobutyronitrile for compounds 1, 5-chlorovaleronitrile for compounds 3 and 6-bromohexanenitrile for compounds 6) (2.5 mmol) in dimethylformamide (1 mL) was added during 1.5 h to a mixture of the arylamine (2.5 mmol), Cs2CO3(2.5 mmol) and KI (5 mmol) in dimethylformamide (2.5mL). The mixture was stirred at the indicated temperature and time. After completion of the reaction, as indicated by TLC, the mixture was treated with ethyl ether (50 mL) and water (10 mL). The aqueous phase was separated and extracted with ethyl ether (30 mL). The combined organic layers were dried over anhydrous sodium sulfate and filtered. The solvent was evaporated in vacuo. The crude product was purified by column chromatography (silica gel, hexane:DCM).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chlorobutyronitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Diaz, Jimena E.; Mollo, Maria C.; Orelli, Liliana R.; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2026 – 2031;,
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New downstream synthetic route of C4H6ClN

The synthetic route of 628-20-6 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 628-20-6, name is 4-Chlorobutyronitrile, A new synthetic method of this compound is introduced below., SDS of cas: 628-20-6

To a solution of 2-bromo-4-nitrophenol (100 g, 0.46 mol) and potassium carbonate (190 g, 1.37 mol) in DMF (1.20 L) was added 4-chlorobutanenitrile (52.1 mL, 550 mmol) and heated at 65 C for 2 h. Ice water was added and the mixture was extracted with ethyl acetate. The organic layer was separated and washed with water and brine, dried over anhydrous sodium sulphate, concentrated and purified by columnchromatography (silica gel, 1:1 ethyl acetate in petroleum ether) to obtain the title compound. Yield: 101 g (77 %); 1H NMR (300 MHz, DMSO-d6): O 2.06-2.17 (m, 2H, -CH2), 2.69 (t, J = 6.0 Hz, 2H, CH2), 4.28 (t, J = 6.0 Hz, 2H, -OCH2), 7.35 (d, J = 9.3 Hz, 1H, Ar), 8.26 (dd, J = 2.7 Hz, 9.3 Hz, 1 H, Ar), 8.43 (d, J = 2.7 Hz, 1 H, Ar); MS: mlz 285.0 (M).

The synthetic route of 628-20-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; SHARMA, Rajiv; KULKARNI, Sarang; KULKARNI, Mahesh; MUKHERJEE, Sumit; YADAV, Rajesh, Kumar; AGARWAL, Madhavi; BURUDKAR, Sandeep; SATHE, Santosh; WO2015/49629; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The important role of C4H6ClN

According to the analysis of related databases, 628-20-6, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 628-20-6 as follows. Quality Control of 4-Chlorobutyronitrile

EXAMPLE 56 5-(3-CHLOROPROPYL)TETRAZOLE A mixture of 3.5 g of 4-chlorobutyronitrile, 2.3 g of sodium azide and 1.9 g of ammonium chloride in 50 ml of dimethyl-formamide is stirred at 140 C. for 20 hours. The reaction mixture is poured onto ice, basified with 1N sodium hydroxide and extracted twice with ethyl acetate. The aqueous fraction is acidified with acetic acid and extracted with ethylacetate. Evaporation of the ethyl acetate gives 5-(3-chloropropyl)-tetrazole which is used directly in the next step.

According to the analysis of related databases, 628-20-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Aventis Pharma Deutschland GmbH; US6376512; (2002); B1;; ; Patent; Jaye, Michael; Duverger, Nicolas; Searfoss, George; Minnich, Anne; US2003/220373; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Simple exploration of 628-20-6

The synthetic route of 628-20-6 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 628-20-6, name is 4-Chlorobutyronitrile, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H6ClN

A mixture of l-methylimidazole (8.21g, 0.10 mmol) and Cl(CH2)3CN (12.43g, 0.12 mol)is stirred at 807deg;C for 24 hours. The resulting white solid is washed with diethyl ether (3 x 30 ml). The product is dried in vacuum for 24 hours. Yield: 17.6 g, 95%; M.p. 80C. ESI-MS(CH3OH): Positive ion: 150 [C,sub>3CNmim], negative ion: 35 [Cl]. 1H NMR (CDCl3): delta= 8.73 (s, 1H), 7.45 (s, 1H), 7.39 (s, 1H), 4.27 (t, J(H, H) = 6.8 Hz, 2H), 3.82 (s, 3H), 2.50 (t, J(H, H) = 6.8 Hz, 2H), 2.20 (t, J(H, H) = 6.8 Hz, 2H). 13C NMR (CDCl3): delta = 134.11, 130.49, 120.01, 116.19, 44.01,30.87, 21.21, 9.87. IR (cm-1): 3373, 3244, 3055 (VC-H aromatic), 3029, 2974, 2949, 2927 (VC-H aliphatic), 2243 (VC-N), 1692 (VC=N). Anal. Calcd for C8H12ClN3 (%): C, 51.76, H, 6.51, N, 22.63; Found: C 51.72, H 6.55, N 22.71.

The synthetic route of 628-20-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL); WO2005/19185; (2005); A1;,
Nitrile – Wikipedia,
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Analyzing the synthesis route of C4H6ClN

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 628-20-6, name is 4-Chlorobutyronitrile, A new synthetic method of this compound is introduced below., COA of Formula: C4H6ClN

A solution of 2- (1-methyl-1H-pyrazol-4-yl) -7- (piperidin-4-yl) -5 – ((2- (trimethylsilyl) ethoxy) -5H-pyrrolo [2,3-b] pyrazine (130 mg, 0.31 mmol)Of acetonitrile (8 mL)Potassium carbonate (110 mg, 0.79 mmol) was added sequentially to the solution,Potassium iodide (10 mg, 0.06 mmol) and4-chlorobutyronitrile (0.05 mL, 0.5 mmol)The reaction was heated at 50 C for 24 hours,Diluted with water (20 mL), extracted with dichloromethane (20 mL x 3), dried over anhydrous sodium sulfate and concentrated column chromatography (dichloromethane / methanol (v / v) = 8/1)120 mg of a yellow oil was obtained in a yield of 79.40%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Bing; Huang Jiuzhong; Zheng Changchun; Zhang Yingjun; Ouyang Luo; Mao Hongfen; Nie Biao; Xu Juan; Chen Hongfen; (137 pag.)CN106336413; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

A new synthetic route of 4-Chlorobutyronitrile

The synthetic route of 628-20-6 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 628-20-6, name is 4-Chlorobutyronitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 628-20-6

K2CO3 663.40g (4.8mol), KI 26.60g (0.16mol),1-(2-methoxy-phenyl)piperazine hydrochloride 457.40 g (2.0 mol),After adding 1500 mL of acetonitrile, 52.70 g (2.4 mol) of 4-chlorobutyronitrile was added dropwise with stirring at 70 C, and after 44.5 h of reaction, the reaction was completed on the spot plate. stop,In order to avoid solid precipitation of [4-(2-methoxyphenyl) piperazinyl]butyronitrile,The mixture was washed with hot water, and the solid was washed well with acetonitrile.Wash the solid slightly with a mixed solvent of acetone and petroleum ether.The mother liquor is evaporated to dryness and then recrystallized with a small amount of acetone petroleum ether.A total of 466.8 g of a white solid was obtained in a total of 90.0% yield.

The synthetic route of 628-20-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Chinese People’s Liberation Army Military Academy Of Medical Sciences Poison Pharmaceutical Institute; Li Jin; Yang Rifang; Song Rui; Wu Ning; Li Yunfeng; Wang Weina; Song Dake; (26 pag.)CN109419802; (2019); A;,
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