Category: 623-00-7

《Enantioselective Three-Component Fluoroalkylarylation of Unactivated Olefins through Nickel-Catalyzed Cross-Electrophile Coupling》 was written by Tu, Hai-Yong; Wang, Fang; Huo, Liping; Li, Yuanbo; Zhu, Shengqing; Zhao, Xian; Li, Huan; Qing, Feng-Ling; Chu, Lingling. Category: nitriles-buliding-blocks And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

A nickel-catalyzed, enantioselective, three-component fluoroalkylarylation of unactivated alkenes with aryl halides and perfluoroalkyl iodides has been described. This cross-electrophile coupling protocol utilizes a chiral nickel/BiOx system as well as a pendant chelating group to facilitate the challenging three-component, asym. difunctionalization of unactivated alkenes, providing direct access to valuable chiral β-fluoroalkyl arylalkanes with high efficiency and excellent enantioselectivity. The mild conditions allow for a broad substrate scope as well as good functional group toleration. Thus, e.g., allylic ester I + 5-bromo-2-(trifluoromethyl)pyrimidine + IC4F9 → II (87%, 94:6 er). In the experiment, the researchers used 4-Bromobenzonitrile(cas: 623-00-7Category: nitriles-buliding-blocks)

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Category: nitriles-buliding-blocks It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Name: 4-BromobenzonitrileIn 2020 ,《Regioselective Hydroalkylation and Arylalkylation of Alkynes by Photoredox/Nickel Dual Catalysis: Application and Mechanism》 was published in Angewandte Chemie, International Edition. The article was written by Yue, Huifeng; Zhu, Chen; Kancherla, Rajesh; Liu, Fangying; Rueping, Magnus. The article contains the following contents:

Alkynes are an important class of organic mols. due to their utility as versatile building blocks in synthesis. Although efforts have been devoted to the difunctionalization of alkynes, general and practical strategies for the direct hydroalkylation and alkylarylation of terminal alkynes under mild reaction conditions are less explored. Herein, a photoredox/nickel dual-catalyzed anti-Markovnikov-type hydroalkylation of terminal alkynes as well as a one-pot arylalkylation of alkynes with alkyl carboxylic acids and aryl bromides via a three-component cross-coupling has been discussed. The results indicate that the transformations proceed via a new mechanism involving a single-electron transfer with subsequent energy-transfer activation pathways. Moreover, steady-state and time-resolved fluorescence-spectroscopy measurements, d. functional theory (DFT) calculations, and wavefunction anal. have been performed to give an insight into the catalytic cycle. In addition to this study using 4-Bromobenzonitrile, there are many other studies that have used 4-Bromobenzonitrile(cas: 623-00-7Name: 4-Bromobenzonitrile) was used in this study.

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Name: 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Enhancement of Lipid Productivity of Chlorella sp. Using Light-Converting Red Fluorescent Films Based on Aggregation-Induced Emission》 was published in ACS Sustainable Chemistry & Engineering in 2020. These research results belong to Hwang, Tae Gyu; Kim, Ga-Yeong; Han, Jong-In; Kim, Suhyeon; Kim, Jae Pil. Recommanded Product: 623-00-7 The article mentions the following:

The conversion of light wavelength from green (500-600 nm) to red (600-700 nm) in the solar spectrum can significantly enhance the biodiesel productivity of microalgae because microalgal photosynthetic pigments utilize the red light more efficiently. Herein, we applied light-converting fluorescent films to enhance the biomass and lipid productivity of oleaginous Chlorella sp. Although the fluorescent dyes have been reported to exhibit excellent fluorescence quantum yields in the solution state, the solid film state is more preferred to overcome limitations such as low stability and potential leakage issues. However, conventional fluorescent dyes exhibit poor emission in the solid film state due to aggregation-caused quenching (ACQ). Therefore, this study utilized aggregation-induced emission (AIE)-type diketopyrrolopyrrole (DPP) fluorescent dyes to overcome the ACQ problems and to fabricate highly efficient light-converting red fluorescent films. The fabricated light-converting film showed excellent photosynthetic photon flux d. increase in the red wavelength range by AIE. A maximum total fatty acid Me ester increase of Chlorella sp. was 28.8% using a light-converting film containing a deep-red (650-700 nm) emitting dye M2. In conclusion, we confirmed that the use of solar energy with light-converting films could boost microalgal productivity efficiently, even without using light-emitting diodes that require electricity. This study suggests a simple and efficient method of using solar energy with light-converting films for boosting microalgal productivity.4-Bromobenzonitrile(cas: 623-00-7Recommanded Product: 623-00-7) was used in this study.

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Recommanded Product: 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《On the Nature of C(sp3)-C(sp2) Bond Formation in Nickel-Catalyzed Tertiary Radical Cross-Couplings: A Case Study of Ni/Photoredox Catalytic Cross-Coupling of Alkyl Radicals and Aryl Halides》 was written by Yuan, Mingbin; Song, Zhihui; Badir, Shorouk O.; Molander, Gary A.; Gutierrez, Osvaldo. Safety of 4-Bromobenzonitrile And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

The merger of photoredox and nickel catalysis has enabled the construction of quaternary centers. However, the mechanism, role of the ligand, and effect of the spin state for this transformation and related Ni-catalyzed cross-couplings involving tertiary alkyl radicals in combination with bipyridine and diketonate ligands remain unknown. Several mechanisms have been proposed, all invoking a key Ni(III) species prior to undergoing irreversible inner-sphere reductive elimination. In this work, we have used open-shell dispersion-corrected DFT calculations, quasi-classical dynamics calculations, and experiments to study in detail the mechanism of carbon-carbon bond formation in Ni bipyridine- and diketonate-based catalytic systems. These calculations revealed that access to high spin states (e.g., triplet spin state tetrahedral Ni(II) species) is critical for effective radical cross-coupling of tertiary alkyl radicals. Further, these calculations revealed a disparate mechanism for the C-C bond formation. Specifically, contrary to the neutral Ni-bipyridyl system, diketonate ligands lead directly to the corresponding tertiary radical cross-coupling products via an outer-sphere reductive elimination step via triplet spin state from the Ni(III) intermediates. Implications to related Ni-catalyzed radical cross-couplings and the design of new transformations are discussed. After reading the article, we found that the author used 4-Bromobenzonitrile(cas: 623-00-7Safety of 4-Bromobenzonitrile)

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Safety of 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Organic semiconductor photocatalyst can bifunctionalize arenes and heteroarenes》 were Ghosh, Indrajit; Khamrai, Jagadish; Savateev, Aleksandr; Shlapakov, Nikita; Antonietti, Markus; Koenig, Burkhard. And the article was published in Science (Washington, DC, United States) in 2019. Product Details of 623-00-7 The author mentioned the following in the article:

In photoredox catalysis, an excited chromophore typically activates a single reactant either by oxidizing or reducing it. Ghosh et al. used a semiconductor catalyst to activate two reactants at once by quenching both an excited electron and the residual pos. hole (see the Perspective by Swift). As such, two different reactive carbon or halide fragments could be appended to sep. sites on an aryl ring. The catalyst also tolerated strong nucleophiles such as cyanide and could be recovered easily and reused. The results came from multiple reactions, including the reaction of 4-Bromobenzonitrile(cas: 623-00-7Product Details of 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Product Details of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 623-00-7In 2020 ,《Supercritical carbon dioxide extraction of a biaryl from model product solutions of a flow Suzuki-Miyaura coupling reaction》 was published in Journal of Chemical Engineering of Japan. The article was written by Fujii, Tatsuya; Kawasaki, Shin-ichiro. The article contains the following contents:

The present study investigates the extraction of a target chem., 4-cyanobiphenyl, from model product solutions of a flow Suzuki-Miyaura coupling reaction. Fast flow extraction from an ethanol aqueous solution of 4-cyanobiphenyl was conducted using supercritical carbon dioxide as the extraction solvent under conditions of 40-60°C and 10-20 MPa. More than 80% of the 4-cyanobiphenyl was recovered in the CO2-rich phase, and the rate was greater than 5.0 g-4-cyanobiphenyl/h for the extraction at 60°C and 20 MPa from the model solution containing salts. The effects of the ethanol mole fraction and the extraction pressure were also investigated to elucidate the effect of changes in the solvent properties on the partitioning behavior. The 4-cyanobiphenyl partition coefficient decreased with increasing ethanol mole fraction and increased with increasing extraction pressure. A model that includes the effects of changes in solubility with increasing CO2 d. and ethanol mole fraction in the water- and CO2-rich phases was developed. The model well represents the tendency of the partitioning behavior, which indicates that the CO2 d. and ethanol mole fraction in each phase are important factors governing the partitioning behavior. In addition to this study using 4-Bromobenzonitrile, there are many other studies that have used 4-Bromobenzonitrile(cas: 623-00-7Related Products of 623-00-7) was used in this study.

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Related Products of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Yamada, Shigeyuki; Yoshida, Keigo; Sakurai, Tsuneaki; Hara, Mitsuo; Konno, Tustome published an article in Molecular Systems Design & Engineering. The title of the article was 《Effect of fluorine atoms in flexible chains on the phase transitions and photophysical behavior of D-π-A-type 4-alkoxy-4′-cyanodiphenylacetylene》.Application of 623-00-7 The author mentioned the following in the article:

D-π-A-type 4-alkoxy-4′-cyanodiphenylacetylenes bearing a decyloxy chain show a nematic liquid crystalline (LC) phase, whereas the incorporation of a semifluoroalkyl fragment results in a switch to the smectic A phase. The D-π-A-type π-conjugated mesogen exhibits photoluminescence, not only in solution and in the crystalline phase, but also in the mol. aggregated structure of the LC phase. In the experiment, the researchers used 4-Bromobenzonitrile(cas: 623-00-7Application of 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Application of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Organic Process Research & Development included an article by Perkins, Robert J.; Hughes, Alexander J.; Weix, Daniel J.; Hansen, Eric C.. Reference of 4-Bromobenzonitrile. The article was titled 《Metal-Reductant-Free Electrochemical Nickel-Catalyzed Couplings of Aryl and Alkyl Bromides in Acetonitrile》. The information in the text is summarized as follows:

While reductive cross-electrochem. coupling is an attractive approach for the synthesis of complex mols. at both small and large scale, two barriers for large-scale applications have remained: the use of stoichiometric metal reductants and a need for amide solvents. In this communication, new conditions that address these challenges are reported. The nickel-catalyzed reductive cross-coupling of aryl bromides with alkyl bromides can be conducted in a divided electrochem. cell using acetonitrile as the solvent and diisopropylamine as the sacrificial reductant to afford coupling products in synthetically useful yields (22-80%). Addnl., the use of a combination of the ligands 4,4′,4”-tri-tert-butyl-2,2′:6′,2′-terpyridine and 4,4′-di-tert-butyl-2,2′-bipyridine is essential to achieve high yields. In the experiment, the researchers used many compounds, for example, 4-Bromobenzonitrile(cas: 623-00-7Reference of 4-Bromobenzonitrile)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Reference of 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Yamada, Shigeyuki; Yoshida, Keigo; Sakurai, Tsuneaki; Hara, Mitsuo; Konno, Tustome published an article in Molecular Systems Design & Engineering. The title of the article was 《Effect of fluorine atoms in flexible chains on the phase transitions and photophysical behavior of D-π-A-type 4-alkoxy-4′-cyanodiphenylacetylene》.Application of 623-00-7 The author mentioned the following in the article:

D-π-A-type 4-alkoxy-4′-cyanodiphenylacetylenes bearing a decyloxy chain show a nematic liquid crystalline (LC) phase, whereas the incorporation of a semifluoroalkyl fragment results in a switch to the smectic A phase. The D-π-A-type π-conjugated mesogen exhibits photoluminescence, not only in solution and in the crystalline phase, but also in the mol. aggregated structure of the LC phase. In the experiment, the researchers used 4-Bromobenzonitrile(cas: 623-00-7Application of 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Application of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Organic Process Research & Development included an article by Perkins, Robert J.; Hughes, Alexander J.; Weix, Daniel J.; Hansen, Eric C.. Reference of 4-Bromobenzonitrile. The article was titled 《Metal-Reductant-Free Electrochemical Nickel-Catalyzed Couplings of Aryl and Alkyl Bromides in Acetonitrile》. The information in the text is summarized as follows:

While reductive cross-electrochem. coupling is an attractive approach for the synthesis of complex mols. at both small and large scale, two barriers for large-scale applications have remained: the use of stoichiometric metal reductants and a need for amide solvents. In this communication, new conditions that address these challenges are reported. The nickel-catalyzed reductive cross-coupling of aryl bromides with alkyl bromides can be conducted in a divided electrochem. cell using acetonitrile as the solvent and diisopropylamine as the sacrificial reductant to afford coupling products in synthetically useful yields (22-80%). Addnl., the use of a combination of the ligands 4,4′,4”-tri-tert-butyl-2,2′:6′,2′-terpyridine and 4,4′-di-tert-butyl-2,2′-bipyridine is essential to achieve high yields. In the experiment, the researchers used many compounds, for example, 4-Bromobenzonitrile(cas: 623-00-7Reference of 4-Bromobenzonitrile)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Reference of 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts