Category: 623-00-7

The author of 《In-situ ultrasonic synthesis of Palladium nanorods into mesoporous channel of SBA-15 and its enhanced catalytic activity for Suzuki coupling reaction》 were Li, Jiazhe; Bai, Xuefeng; Lv, Hongfei. And the article was published in Microporous and Mesoporous Materials in 2019. Synthetic Route of C7H4BrN The author mentioned the following in the article:

Palladium nanorods (PdNRs) into mesoporous channels of SBA-15 nanocatalyst (PdNRs/SBA-15) were synthesized by a green and surfactant-free ultrasonic method without any surfactants and complex chem. modification and chem. method in absence of ultrasound, resp. The PdNRs/SBA-15 catalysts were characterized by XRD, TEM, XPS, N2 absorption-desorption and FT-IR anal. The results showed that PdNRs with 15.96 ± 3.89 nm long and 5.69 nm wide were highly dispersed into mesoporous channels exploiting the confinement effect of SBA-15 pore channel, while reunited PdNPs were distributed on the outside surface of SBA-15 in PdNPs/SBA-15 prepared by chem. method. The in-situ ultrasonic reduction of PdNRs/SBA-15 by the reductive radical (induced by ultrasonic process) was good for higher dispersion of Pd species and the formation of Pd species inside the mesoporous channel of SBA-15 without any structure-directing agents or surfactants. The yield of Suzuki coupling reaction between 4-bromotoluene and phenylboronic acid catalyzed by PdNRs (5)/SBA-15 reached 96.4%, which was much higher than that of PdNPs(5)/SBA-15 prepared without ultrasound (76.3%). PdNRs (5)/SBA-15 could be reused up to five times without a significant activity loss due to the strong chem. interaction and the unblocked channel. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobenzonitrile(cas: 623-00-7Synthetic Route of C7H4BrN)

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Synthetic Route of C7H4BrN It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Akkoc, Mitat; Bugday, Nesrin; Altin, Serdar; Kiraz, Nadir; Yasar, Sedat; Ozdemir, Ismail published their research in Journal of Organometallic Chemistry in 2021. The article was titled 《N-heterocyclic carbene Pd(II) complex supported on Fe3O4@SiO2: Highly active, reusable and magnetically separable catalyst for Suzuki-Miyaura cross-coupling reactions in aqueous media》.Related Products of 623-00-7 The article contains the following contents:

A new type magnetic nano Fe3O4@SiO2@NHC@Pd-MNPs heterogeneous catalyst was fabricated and characterized by Fourier Transform IR (FTIR) spectroscopy, Transmission Electron Microscopy (TEM), X-Ray Diffraction (XRD), XPS, Energy Disperse X-ray anal. (EDX), Thermogravimetric Anal. (TGA), DTA (DTA), and SEM (SEM). The loading amount of palladium (Pd) to magnetic nano Fe3O4@SiO2@NHC@Pd-MNPs was measured by Inductively Coupled Plasma-Optical Emission Spectroscopy (ICP-OES) anal. The catalytic activity of magnetic nano Fe3O4@SiO2@NHC@Pd-MNPs heterogeneous catalyst was examined on Suzuki-Miyaura cross-coupling reactions of aryl halides with different substituted arylboronic acid derivatives All coupling reactions yielded excellent results and high TOF (up to 76528 h-1) in the presence of 2 mg of Fe3O4@SiO2@NHC@Pd-MNPs catalyst (0.0197 mmolg-1, 0.00394 mmol%Pd) at 80° in 2-propanol/H2O (1:2). In addition, the magnetic nano Fe3O4@SiO2@NHC@Pd-MNPs catalyst was easily recovered by using an external Nd-magnet and reused for the Suzuki cross-coupling reactions. The catalyst showed strong structural and chem. stability and was reused six times without losing its catalytic activity substantially. In the experimental materials used by the author, we found 4-Bromobenzonitrile(cas: 623-00-7Related Products of 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Related Products of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《General Method for Enantioselective Three-Component Carboarylation of Alkenes Enabled by Visible-Light Dual Photoredox/Nickel Catalysis》 was published in Journal of the American Chemical Society in 2020. These research results belong to Guo, Lei; Yuan, Mingbin; Zhang, Yanyan; Wang, Fang; Zhu, Shengqing; Gutierrez, Osvaldo; Chu, Lingling. Application of 623-00-7 The article mentions the following:

A visible-light-promoted photoredox/nickel protocol for the enantioselective three-component carboarylation of alkenes with tertiary and secondary alkyltrifluoroborates and aryl bromides is described. This redox-neutral protocol allows for facile and divergent access to a wide array of enantioenriched β-alkyl-α-arylated carbonyls, phosphonates, and sulfones in high yields and excellent enantioselectivities from readily available starting materials. We also report a modular and enantioselective synthesis of flurbiprofen analogs and piragliatin lead compound to demonstrate synthetic utility. Exptl. and computational mechanistic studies were performed to gain insights into the mechanism and origin of chemo- and enantioselectivity. The experimental process involved the reaction of 4-Bromobenzonitrile(cas: 623-00-7Application of 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Application of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《General Paradigm in Photoredox Nickel-Catalyzed Cross-Coupling Allows for Light-Free Access to Reactivity》 was written by Sun, Rui; Qin, Yangzhong; Nocera, Daniel G.. Application of 623-00-7 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Self-sustained NiI/III cycles were established as a potentially general paradigm in photoredox Ni-catalyzed carbon-heteroatom cross-coupling reactions through a strategy that allows the authors to recapitulate photoredox-like reactivity in the absence of light across a wide range of substrates in the amination, etherification, and esterification of aryl bromides, the latter of which has remained, hitherto, elusive under thermal Ni catalysis. Moreover, the accessibility of esterification in the absence of light is especially notable because previous mechanistic studies on this transformation under photoredox conditions have unanimously invoked energy-transfer-mediated pathways.4-Bromobenzonitrile(cas: 623-00-7Application of 623-00-7) was used in this study.

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Application of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Angewandte Chemie, International Edition included an article by Liu, Dong; Ma, Hong-Xing; Fang, Ping; Mei, Tian-Sheng. Reference of 4-Bromobenzonitrile. The article was titled 《Nickel-Catalyzed Thiolation of Aryl Halides and Heteroaryl Halides through Electrochemistry》. The information in the text is summarized as follows:

The Nickel-catalyzed electrochem. thiolation of aryl bromides and chlorides in the absence of an external base at room temperature using undivided electrochem. cells was reported for the synthesis of diaryl sulfides e.g., I. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobenzonitrile(cas: 623-00-7Reference of 4-Bromobenzonitrile)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Reference of 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bortnikov, Evgeniy O.; Semenov, Sergey N. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Coupling of Alternating Current to Transition-Metal Catalysis: Examples of Nickel-Catalyzed Cross-Coupling》.Reference of 4-Bromobenzonitrile The article contains the following contents:

The coupling of transition-metal to photoredox catalytic cycles through single-electron transfer steps has become a powerful tool in the development of catalytic processes. In this work, we demonstrated that transition-metal catalysis can be coupled to a.c. (AC) through electron transfer steps that occur periodically at the same electrode. AC-assisted Ni-catalyzed amination, etherification, and esterification of aromatic bromides showed higher yields and selectivity compared to that observed in the control experiments with d.c. Our mechanistic studies suggested the importance of both reduction and oxidation processes in the maintenance of the AC-assisted catalytic reactions. As described in presented examples, the AC assistance should be well-suited for catalytic cycles involving reductive elimination or oxidative addition as a limiting step.4-Bromobenzonitrile(cas: 623-00-7Reference of 4-Bromobenzonitrile) was used in this study.

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Reference of 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Luo, Jian; Hu, Bo; Wu, Wenda; Hu, Maowei; Liu, T. Leo published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Nickel-Catalyzed Electrochemical C(sp3)-C(sp2) Cross-Coupling Reactions of Benzyl Trifluoroborate and Organic Halides》.Related Products of 623-00-7 The article contains the following contents:

Reported here is the redox neutral electrochem. C(sp2)-C(sp3) cross-coupling reaction of bench-stable aryl halides or β-bromostyrene (electrophiles) and benzylic trifluoroborates (nucleophiles) using nonprecious, bench-stable NiCl2·glyme/polypyridine catalysts in an undivided cell configuration under ambient conditions. The broad reaction scope and good yields of the Ni-catalyzed electrochem. coupling reactions were confirmed by 50 examples of aryl/β-styrenyl chloride/bromide and benzylic trifluoroborates. Potential applications were demonstrated by electrosynthesis and late-stage functionalization of pharmaceuticals and natural amino acid modification, and three reactions were run on gram-scale in a flow-cell electrolyzer. The electrochem. C-C cross-coupling reactions proceed through an unconventional radical transmetalation mechanism. This method is highly productive and expected to find wide-spread applications in organic synthesis. In the experiment, the researchers used many compounds, for example, 4-Bromobenzonitrile(cas: 623-00-7Related Products of 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Related Products of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Dong; Liu, Zhao-Ran; Ma, Cong; Jiao, Ke-Jin; Sun, Bing; Wei, Lei; Lefranc, Julien; Herbert, Simon; Mei, Tian-Sheng published an article in 2021. The article was titled 《Nickel-Catalyzed N-Arylation of NH-Sulfoximines with Aryl Halides via Paired Electrolysis》, and you may find the article in Angewandte Chemie, International Edition.Formula: C7H4BrN The information in the text is summarized as follows:

A novel strategy for the N-arylation of NH-sulfoximines has been developed by merging nickel catalysis and electrochem. (in an undivided cell), thereby providing a practical method for the construction of sulfoximine derivatives Paired electrolysis is employed in this protocol, so a sacrificial anode is not required. Owing to the mild reaction conditions, excellent functional group tolerance and yield are achieved. A preliminary mechanistic study indicates that the anodic oxidation of a NiII species is crucial to promote the reductive elimination of a C-N bond from the resulting NiIII species at room temperature In the part of experimental materials, we found many familiar compounds, such as 4-Bromobenzonitrile(cas: 623-00-7Formula: C7H4BrN)

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Formula: C7H4BrN It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Niknam, Esmaeil; Panahi, Farhad; Khalafi-Nezhad, Ali published an article in 2021. The article was titled 《Immobilized Pd on a NHC-functionalized metal-organic framework MIL-101(Cr): an efficient heterogeneous catalyst in the Heck and copper-free Sonogashira coupling reactions》, and you may find the article in Journal of Organometallic Chemistry.Safety of 4-Bromobenzonitrile The information in the text is summarized as follows:

A heterogeneous palladium catalyst system based on immobilization of palladium moieties on a N-heterocyclic carbene (NHC) modified metal organic framework (MOF) was developed for the Heck and copper-free Sonogashira coupling reactions. In order to prepare this catalyst system, first, MIL-101(Cr) was functionalized with NHC moieties through a post-synthetic modification (PSM) approach, and then Pd metal was stabilized on the prepared MIL-101(Cr)-NHC substrate. This material was characterized using various microscopic and spectroscopic techniques and then was used as an efficient heterogeneous Pd catalyst system in the Heck and copper-free Sonogashira reactions. Results of the heterogeneity tests showed that the Pd-NHC-MIL-101(Cr) catalyst can efficiently catalyzed these coupling reactions heterogeneously and no remarkable changes observed in the morphol. and structure of MIL-101(Cr) template during the reaction progress. Also, existence of palladium nanoparticles immobilized on the MOF structure affirmed by the TEM and XPS anal. confirmed the oxidation state of Pd. A variety of alkene and alkyne derivatives were synthesized in good to excellent yields using this heterogeneous Pd catalyst system under normal conditions. More importantly Pd-NHC-MIL-101(Cr) catalyst was simply recovered from the reaction medium without remarkable decreasing in its catalytic activities after five times of reusability. The ICP anal. showed the very low Pd and Cr metals leaching, representing high stability and applicability of this catalyst in Pd coupling reactions. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobenzonitrile(cas: 623-00-7Safety of 4-Bromobenzonitrile)

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Safety of 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Cascade Cross-Coupling of Dienes: Photoredox and Nickel Dual Catalysis》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Huang, Long; Zhu, Chen; Yi, Liang; Yue, Huifeng; Kancherla, Rajesh; Rueping, Magnus. Formula: C7H4BrN The article mentions the following:

Chem. transformations based on cascade reactions have the potential to simplify the preparation of diverse and architecturally complex mols. dramatically. Herein, the authors disclose an unprecedented and efficient method for the cross-coupling of radical precursors, dienes, and electrophilic coupling partners via a photoredox- and nickel-enabled cascade cross-coupling process. The cascade reaction furnishes a diverse array of saturated carbo- and heterocyclic scaffolds, thus providing access to a quick gain in C-C bond saturation In the experimental materials used by the author, we found 4-Bromobenzonitrile(cas: 623-00-7Formula: C7H4BrN)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Formula: C7H4BrN It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts