Category: 623-00-7

《A hydrophilic heterogeneous cobalt catalyst for fluoride-free Hiyama, Suzuki, Heck and Hirao cross-coupling reactions in water》 was written by Sobhani, Sara; Hosseini Moghadam, Hadis; Skibsted, Joergen; Sansano, Jose Miguel. SDS of cas: 623-00-7 And the article was included in Green Chemistry in 2020. The article conveys some information:

A hydrophilic heterogeneous cobalt catalyst of chitosan, denoted as mTEG-CS-Co-Schiff-base, has been successfully prepared This newly synthesized catalyst was characterized by different methods such as XRD, FE-SEM, TEM, TGA, FT-IR, 13C{1H} CP/MAS NMR, XPS and ICP analyses. The catalyst displayed excellent activity for the palladium and fluoride-free Hiyama, Suzuki, Heck and Hirao reactions of various aryl iodides 4-RC6H4I (R = H, OMe, Cl, I), bromides 4-R1C6H4Br (R1 = H, OMe, NO2, CN, Cl, Me, Br)/(2-bromoethenyl)benzene and chlorides 4-R2C6H4Cl (R2 = H, NO2, CN, Me) (i.e., the most challenging aryl halides which are cheaper and more widely available than aryl iodides and bromides) in water. The presence of triethylene glycol tags with hydrophilic character on the Co-complex supported on chitosan provides dispersion of the catalyst particles in water, which leads to higher catalytic performance and also facile catalyst recovery by successive extraction The catalyst was reused for at least six successive runs without any discernible decrease in its catalytic activity or any remarkable changes in catalyst structure. The use of water as a green solvent, without requiring any additive or organic solvent, as well as use of a low cost and abundant cobalt catalyst instead of expensive Pd catalysts along with the catalyst recovery and scalability, make this method favorable from environmental and economic points of view for the C-C and C(sp2)-P coupling reactions. Notably, this is the first report on the application of a cobalt catalyst in Hiyama reactions. In the experiment, the researchers used many compounds, for example, 4-Bromobenzonitrile(cas: 623-00-7SDS of cas: 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,SDS of cas: 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,ChemCatChem included an article by Ichitsuka, Tomohiro; Suzuki, Naoto; Sairenji, Masaki; Koumura, Nagatoshi; Onozawa, Shun-ya; Sato, Kazuhiko; Kobayashi, Shu. Recommanded Product: 4-Bromobenzonitrile. The article was titled 《Readily Available Immobilized Pd Catalysts for Suzuki-Miyaura Coupling under Continuous-flow Conditions》. The information in the text is summarized as follows:

A consistent method was developed for evaluating the catalytic performance of com. available immobilized Pd-catalysts under continuous-flow conditions for the preparation of biaryls via Suzuki-Miyaura coupling of aryl bromides with arylboronic acids. Monitoring of the change in turnover frequency over time under excess substrate loading conditions revealed the limitation of these catalysts. In addition to this study using 4-Bromobenzonitrile, there are many other studies that have used 4-Bromobenzonitrile(cas: 623-00-7Recommanded Product: 4-Bromobenzonitrile) was used in this study.

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Recommanded Product: 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Photo-Ni-Dual-Catalytic C(sp2)-C(sp3) Cross-Coupling Reactions with Mesoporous Graphitic Carbon Nitride as a Heterogeneous Organic Semiconductor Photocatalyst》 was published in ACS Catalysis in 2020. These research results belong to Khamrai, Jagadish; Ghosh, Indrajit; Savateev, Aleksandr; Antonietti, Markus; Koenig, Burkhard. Application In Synthesis of 4-Bromobenzonitrile The article mentions the following:

The synergistic combination of a heterogeneous organic semiconductor mesoporous graphitic carbon nitride (mpg-CN) and a homogeneous nickel catalyst with visible-light irradiation at room temperature affords the C(sp2)-C(sp3) cross-coupling of aryl halides and potassium alkyl trifluoroborates by single electron transmetallation. Like the homogeneously catalyzed protocol, the reaction is compatible with a variety of functional groups including electron-donating and electron-withdrawing aryl and heteroaryl moieties. Moreover, this protocol allows the installation of allyl groups onto (hetero)arenes, enlarging the scope of the method. The heterogeneous mpg-CN photocatalyst is easily recovered from the reaction mixture and reused several times, paving the way for larger-scale industrial applications of this type of photocatalytic bond-forming reactions. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobenzonitrile(cas: 623-00-7Application In Synthesis of 4-Bromobenzonitrile)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Application In Synthesis of 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Novel phenoxazine-benzonitrile and phenothiazine-benzonitrile donor-acceptor molecules with thermally activated delayed fluorescence (TADF)》 was written by Baraket, Faiza; Pedras, Bruno; Torres, Erica; Brites, Maria Joao; Dammak, Mohamed; Berberan-Santos, Mario N.. COA of Formula: C7H4BrN And the article was included in Dyes and Pigments in 2020. The article conveys some information:

Four novel TADF emitters, containing phenothiazine and phenoxazine as electron-donors and benzonitrile derivatives as electron-acceptors were synthesized and fully characterized. Their photophys. (absorption and emission spectra, molar extinction coefficients, fluorescence quantum yields and lifetimes) and electrochem. properties (HOMO and LUMO energy levels) were measured, and drop-cast solid films of the four compounds were obtained to perform TADF studies. The obtained values for ΔEST indicate that these compounds are candidates for OLED applications. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobenzonitrile(cas: 623-00-7COA of Formula: C7H4BrN)

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.COA of Formula: C7H4BrN It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Yanhong; Han, Zhe; Yang, Yiying; Zhu, Rongxiu; Liu, Chengbu; Zhang, Dongju published their research in Molecular Catalysis in 2021. The article was titled 《DFT study on synergetic Ir/Cu-metallaphotoredox catalyzed trifluoromethylation of aryl bromides》.Product Details of 623-00-7 The article contains the following contents:

MacMillan et al. recently developed an elegant strategy for trifluoromethylation of aryl halides by merging iridium photoredox catalysis with copper catalysis [Science 360 (2018) 1010-1014]. The present work presents a complementary theor. study to better understand the dual photoredox-copper catalysis. Calculated results confirm that the most possible photoredox catalytic cycle proceeds via a reductive quenching mechanism (IrIII/*IrIII/IrII/IrIII) with supersilanol as quencher and the CF3 reagent as oxidant. The formation of aryl radical involves three essential steps: deprotonation of the oxidized supersilanol by Na2CO3 to form the O-centered radical species, SiMe3 group migration to give the Si-centered silyl radical, bromine atom abstraction from aryl bromide. The CF3 radical can be obtained via the fragmentation process of the reduced CF3 reagent. The additions of both aryl radical and CF3 radical on the CuI center generates CuIII complex, from which the desired trifluoromethylation product is obtained via the C(sp2)-CF3 reductive elimination. All these processes were found to involve low barriers, and the highest one is only 12.7 kcal/mol, providing support of the viable trifluoromethylation strategy using copper catalysis via the radical trapping mechanism rather than the conventional oxidative addition mechanism. The results came from multiple reactions, including the reaction of 4-Bromobenzonitrile(cas: 623-00-7Product Details of 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Product Details of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Organic Letters included an article by Wimmer, Alexander; Koenig, Burkhard. Name: 4-Bromobenzonitrile. The article was titled 《N-Arylation of NH-Sulfoximines via Dual Nickel Photocatalysis》. The information in the text is summarized as follows:

The pharmaceutically underexplored sulfoximine moiety has emerged as a potentially active pharmaceutical ingredient. We developed a scalable synthetic route to N-arylated sulfoximines from the resp. “”free”” NH-sulfoximines and bromoarenes. Our strategy is based on a dual nickel photocatalytic approach, is applicable for a broad scope of substrates, and exhibits a highly functional group tolerance. In addition, we could demonstrate that other sulfoximidoyl derivatives like sulfonimidamides and sulfinamides proceed smoothly under the developed reaction conditions. In the experiment, the researchers used 4-Bromobenzonitrile(cas: 623-00-7Name: 4-Bromobenzonitrile)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Name: 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Liang, Yu-Jie; Zhu, Bo; Su, Zhong-Min; Guan, Wei published an article in Inorganic Chemistry. The title of the article was 《IrIII/NiII-Metallaphotoredox-Catalyzed Enantioselective Decarboxylative Arylation of α-Amino Acids: Theoretical Insight of Enantio-Determining Outer-Sphere Reductive Elimination》.Synthetic Route of C7H4BrN The author mentioned the following in the article:

The IrIII/NiII-metallaphotoredox-catalyzed enantioselective decarboxylative arylation of α-amino acids has been systematically investigated using d. functional theory calculations The combination of oxidative quenching (IrIII-*IrIII-IrIV-IrIII) or reductive quenching (IrIII-*IrIII-IrII-IrIII) cycle with the nickel catalytic cycle (NiII-NiI-NiIII-NiII) is possible. The favorable reaction mechanism consists of three major processes: single-electron transfer, oxidative addition, and stepwise outer-sphere reductive elimination. The rate-determining step is the oxidative addition Unexpectedly, the enantio-determining C-C bond formation occurs via an ion-pair intermediate involved in the stepwise outer-sphere reductive elimination process, which is unusual in the IrIII/NiII-metallaphotoredox catalysis. Furthermore, computational results reveal that the high enantioselectivity of this reaction is mainly dependent on the steric effect of substituents on substrates. This theor. study provides useful knowledge for deep insights into the activity and selectivity of visible-light-mediated enantioselective metallaphotoredox dual catalysis at the mol. and at. levels and benefits the development of asym. synthesis. In the experimental materials used by the author, we found 4-Bromobenzonitrile(cas: 623-00-7Synthetic Route of C7H4BrN)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Synthetic Route of C7H4BrN It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Formula: C7H4BrNIn 2019 ,《Semiheterogeneous Dual Nickel/Photocatalytic (Thio)etherification Using Carbon Nitrides》 was published in Organic Letters. The article was written by Cavedon, Cristian; Madani, Amiera; Seeberger, Peter H.; Pieber, Bartholomaeus. The article contains the following contents:

A carbon nitride material can be combined with homogeneous nickel catalysts for light-mediated cross-couplings of aryl bromides with alcs. under mild conditions. The metal-free heterogeneous semiconductor is fully recyclable and couples a broad range of electron-poor aryl bromides with primary and secondary alcs. as well as water. The application for intramol. reactions and the synthesis of active pharmaceutical ingredients was demonstrated. The catalytic protocol is applicable for the coupling of aryl iodides with thiols as well. In addition to this study using 4-Bromobenzonitrile, there are many other studies that have used 4-Bromobenzonitrile(cas: 623-00-7Formula: C7H4BrN) was used in this study.

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Formula: C7H4BrN It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Imidazolium chloride-Co(III) complex immobilized on Fe3O4@SiO2 as a highly active bifunctional nanocatalyst for the copper-, phosphine-, and base-free Heck and Sonogashira reactions》 were Kazemnejadi, Milad; Alavi G., Seyyedeh Ameneh; Rezazadeh, Zinat; Nasseri, Mohammad Ali; Allahresani, Ali; Esmaeilpour, Mohsen. And the article was published in Green Chemistry in 2019. Category: nitriles-buliding-blocks The author mentioned the following in the article:

A heterogeneous, magnetically recoverable Fe3O4@SiO2@Im[Cl]Co(III)-melamine nanocomposite was prepared by immobilization of a novel Co(III) Schiff base complex on Fe3O4@SiO2 nanoparticles followed by treatment with melamine, and was found to be an efficient catalyst for the Heck and Sonogashira reactions. The reactions were performed in the presence of the catalyst (0.5 mol% Co) along with Mn additive in the absence of any base, phosphine ligand, or Cu/co-catalyst in ethanol under reflux conditions. The nanocatalyst was well studied by FTIR, CHN, XRD, XPS, TGA, EDX, VSM, ICP, NMR, FE-SEM, TEM, BET, CV, and DLS analyses. The catalyst was compatible with a variety of substrates, with which all the Heck and Sonogashira coupling products were obtained in high to excellent yields. Also, protocols such as hot filtration, three-phase testing, and mercury poisoning provided a complete insight into the nature of the heterogeneous catalyst. The recycling and reuse of the catalyst were studied for both coupling reactions several times. Moreover, the mechanism of the coupling reactions was entirely investigated. The experimental process involved the reaction of 4-Bromobenzonitrile(cas: 623-00-7Category: nitriles-buliding-blocks)

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Category: nitriles-buliding-blocks It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Pd NPs@Fe3O4/chitosan/pumice hybrid beads: A highly active, magnetically retrievable, and reusable nanocatalyst for cyanation of aryl halides》 was written by Baran, Talat. Recommanded Product: 623-00-7 And the article was included in Carbohydrate Polymers in 2020. The article conveys some information:

In this study, Fe3O4/chitosan/pumice hybrid beads were developed as a new stabilizer agent, and palladium nanoparticles (Pd NPs) were successfully decorated on the designed stabilizer without adding any toxic reducing resource. Then, the potential use of Pd NPs@Fe3O4/chitosan/pumice hybrid beads as a heterogeneous catalyst against different aryl halide cyanations was investigated with K4[Fe(CN)6]. In these reactions, Pd NPs@ Fe3O4/chitosan /pumice hybrid beads showed high catalytic activity by converting aryl halides to the desired benzonitriles with high product yields (80%-98%). Due to the magnetically separable nature of Pd NPs@Fe3O4/chitosan/pumice hybrid beads, they were reused several times, and 86% yield was obtained even after six successive runs. This paper reveals that Pd NPs@Fe3O4/chitosan/pumice hybrid beads have a high potential to synthesis a broad range of nitriles due to their excellent catalytic and retrievable capability. After reading the article, we found that the author used 4-Bromobenzonitrile(cas: 623-00-7Recommanded Product: 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Recommanded Product: 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts