Category: 622-75-3

622-75-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 622-75-3, name is 2,2′-(1,4-Phenylene)diacetonitrile, A new synthetic method of this compound is introduced below.

Add 4- (2-oxiranylmethoxy) benzaldehyde (0.01 mol, 1.78 g), terephthalonitrile (0.0045 mol, 0.7000 g), and 150 mL of ethanol to a 250-mL single-necked bottle, and stir for 10 minutes. After several minutes, solid potassium hydroxide (0.03 mol, 1.68 g) was added, and after 4 to 6 hours of reaction, the reaction was stopped.After the temperature of the reaction system was cooled to room temperature, the solid product was collected by suction filtration, washed with water and dried to obtain a crude product. The crude product was recrystallized from a mixed solvent of DMF and ethanol (V: V = 3: 1) to obtain a pure yellow product 1.95. g, yield 93%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Xiangtan University; Zhang Hailiang; Tan Huiping; Yuan Yongjie; Yang Bohao; (15 pag.)CN110407772; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

622-75-3, A common compound: 622-75-3, name is 2,2′-(1,4-Phenylene)diacetonitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Weigh 1,4-benzenediacetonitrile 0.807 g (5.17 mmoL) was dissolved in 20 mL of ethanol,Add NaOH for 0.5h, weighed the first step of the synthesis of the product 3g (10.3mmoL) added to the flask for 3h,The reaction solution was washed with saturated brine and dried over anhydrous sodium sulfate. After filtration, the solvent was distilled off under reduced pressure,To give 2.75 g of a pale yellow solid;

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2′-(1,4-Phenylene)diacetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hefei University of Technology; LU, HONG BO; ZHANG, SHAN NA; YANG, JIA XIANG; LU, GUO QIANG; QIU, LONG ZHEN; ZHANG, GUI YU; XU, WEI; (11 pag.)CN103641742; (2016); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

622-75-3, A common heterocyclic compound, 622-75-3, name is 2,2′-(1,4-Phenylene)diacetonitrile, molecular formula is C10H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Complex 1 was prepared by mixing of Ag(CF3SO3) (0.0308g, 0.120mmol) and p-phda (0.0099g, 0.0634mmol) in 4mL benzene or m-xylene. After stirring for 30min, the resultant solution was introduced into a 9mm diameter glass tube and layered with n-pentane (4mL) as a diffusion solvent. After standing at room temperature for one week, colorless crystals of 1 suitable for single crystal X-ray analysis were obtained. Yield: 64.42%. Anal. Calc. for C12H8Ag2F6N2O6S2 C, 21.51; N, 4.18; H, 1.21; Found: C, 21.52;N, 4.15; H, 1.19%. IR (KBr, nu/cm-1): 2920(w), 2300(w), 2250(w),1520(w), 1420(w), 1290(s), 1260(s), 1260(s), 1170(s), 1030(s), 933(m), 783(w), 629(s), 519(m).

The synthetic route of 622-75-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Han, Jing; Yang, Jian; Yu, Zhong; Wang, Quan-jiu; Inorganica Chimica Acta; vol. 469; (2018); p. 318 – 324;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 622-75-3, name is 2,2′-(1,4-Phenylene)diacetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 622-75-3

Synthesis of PIDSB: PIDSB was prepared by knoevenagel condensation reaction.In a 100 mL round bottom flask, PICHO(8mmol, 3.18g),The p-benzenediacetonitrile (4 mmol, 0.63 g) was dissolved in 50 mL of tetrahydrofuran and 25 ml of t-butanol, and the temperature was raised to 46 C under a nitrogen atmosphere.1 ml of tetrabutylammonium hydroxide (TBAH) and a solution of 80 mg of potassium t-butoxide in tetrahydrofuran were prepared in advance.After half an hour of reaction, the system was poured into acetic acidified methanol solution at room temperature.The crude product was obtained by suction filtration and separated by column chromatography ( petroleum ether: methylene chloride = 1:5,The volume ratio) gave a red powdery solid (1.96 g, yield: 53%).Mass spectrum MALDI-TOF (m/z) [M+]: The found value was 917.56 and the theoretical value was 916.33.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 622-75-3.

Reference:
Patent; Jilin University; Lu Ping; Sun Xiaoyi; Li Jinyu; (13 pag.)CN108822040; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts