In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 621-03-4, name is 2-Cyano-N-phenylacetamide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 621-03-4
General procedure: To a solution of cyclohexan-1,4-dione (1.12 g, 0.01 mol) in1,4-dioxane (40 mL) containing triethylamine (0.50 mL) each of elemental sulfur (0.32 g, 0.01 mol) and any of 2-cyano-N-phenylacetamide (1.60 g, 0.01 mol), N-(4-chlorophenyl)-2-cyanoacetamide (1.94 g, 0.01 mol) or N-(4-nitrophenyl)-2-cyanoacetamide (2.05 g, 0.01 mol) wereadded. The reaction mixture was heated under reflux for 2 hthen poured onto ice/water containing few drops of hydrochloricacid. The formed solid product, in each case, wascollected by filtration.2-Amino-6-oxo-N-phenyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (3a) Orange crystals (ethanol), yield70% (2.00 g), m.p. 183-185 C; (IR (KBr) numax 3493, 3329,3055, 2984, 1689, 1639, 1583; 1H NMR (DMSO-d6, 200MHz): delta = 8.28 (s, 1H, D2O exchangeable, NH), 7.48-7.24(m, 4H, C6 H4), 4.85 (s, 2H, D2O exchangeable, NH2), 2.79(s, 2H, CH2), 1.92-1.65 (2t, 4H, 2CH2), 13C NMR (DMSOd6,75MHz): delta = 166.2, 164.8 (2CO), 141.8, 140.2, 138.4,133.5, 127.2, 124.8, 122.5, 120.5 (C6H5, thiophene C),40.0, 38.8, 18.6 (3CH2); EIMS: m/z 286 [M]+ (26%);analysis calcd for C15H14N2O2S (286.35): C, 62.96; H,4.93; N, 9.78; S, 11.20%. Found: C, 63.19; H, 4.69; N,9.84; S, 11.36%.
The synthetic route of 621-03-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Mohareb, Rafat M.; Al-Omran, Fatima; Ibrahim, Rehab A.; Medicinal Chemistry Research; vol. 27; 2; (2018); p. 618 – 633;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts