Category: 614-16-4

《Nucleophilic Iron Complexes in Proton-Transfer Catalysis: An Iron-Catalyzed Dimroth Cyclocondensation》 was written by Baykal, Aslihan; Zhang, Dihan; Knelles, Jakob; Alt, Isabel T.; Plietker, Bernd. Quality Control of 3-Oxo-3-phenylpropanenitrileThis research focused ontriazole preparation; aryl azide ketone Dimroth cyclocondensation reaction iron catalyst; Dimroth cyclocondensation; cyclocondensation-C−H-amination; homogeneous catalysis; iron; triazoles. The article conveys some information:

The nucleophilic iron complex Bu4N[Fe(CO)3(NO)](TBA[Fe]) is an active catalyst in C-H-amination but also in proton-transfer catalysis. Herein, the successful use of this complex as a proton-transfer catalyst in the cyclocondensation reaction between azides R1N3 (R1 = Ph, 4-nitrophenyl, naphthalen-2-yl, pyridin-3-yl, etc.) and ketones R2C(O)CH2R3 (R2 = Me, 1-methyl-1H-imidazol-2-yl, 1-methyl-1H-1,3-benzodiazol-2-yl, Ph, etc.; R3 = C(O)Me, Ph, thiophen-3-yl, CN, etc.) to the corresponding 1,2,3-triazoles I has been described. Cross-experiments indicate that the proton-transfer catalysis is significantly faster than the nitrene-transfer catalysis, which would lead to the C-H amination product. An example of a successful sequential Dimroth triazole-indoline synthesis to the corresponding triazole-substituted indolines II (R4 = Ph, 1-methyl-1H-imidazol-2-yl) is presented. In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Quality Control of 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Quality Control of 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Hypervalent Iodine(III)-Catalysed Enantioselective α-Acetoxylation of Ketones》 was published in Chemistry – A European Journal in 2020. These research results belong to Hokamp, Tobias; Wirth, Thomas. Electric Literature of C9H7NO The article mentions the following:

An enantioselective catalytic synthesis of α-acetoxylated ketones through I(I)/I(III) catalysis using a resorcinol/lactamide-based chiral iodoarene was reported. Catalyst turnover by in-situ generation of the active iodine(III) derivative was achieved by oxidation with mCPBA in the presence of acetic acid. The prior transformation of ketones to easily accessible acetyl enol ethers was beneficial and yields up to 97% with enantioselectivities up to 88% ee were obtained using only low catalyst loadings of only 5 mol % under mild reaction conditions. In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Electric Literature of C9H7NO)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Electric Literature of C9H7NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Optical Control of GABAA Receptors with a Fulgimide-Based Potentiator》 was written by Rustler, Karin; Maleeva, Galyna; Gomila, Alexandre M. J.; Gorostiza, Pau; Bregestovski, Piotr; Koenig, Burkhard. Recommanded Product: 3-Oxo-3-phenylpropanenitrile And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:

Optogenetic and photopharmacol. tools to manipulate neuronal inhibition have limited efficacy and reversibility. We report the design, synthesis, and biol. evaluation of Fulgazepam, a fulgimide derivative of benzodiazepine that behaves as a pure potentiator of ionotropic γ-aminobutyric acid receptors (GABAARs) and displays full and reversible photoswitching in vitro and in vivo. The compound enables high-resolution studies of GABAergic neurotransmission, and phototherapies based on localized, acute, and reversible neuroinhibition. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Recommanded Product: 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Recommanded Product: 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wei, Yueting; Liu, Ping; Liu, Yali; He, Jing; Li, Xuezhen; Li, Shiwu; Zhao, Jixing published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《NIS-promoted three-component reaction of 3-oxo-3-arylpropanenitriles with arylsulfonyl hydrazides》.Related Products of 614-16-4 The article contains the following contents:

A new three-component reaction of 3-oxo-3-arylpropanenitriles with arylsulfonyl hydrazides was established and an expanded inventory of 3-aryl-4-(arylthio)-1H-pyrazol-5-amines were synthesized by sequential cyclization and sulfenylation reactions under the action of NIS. In addition to the attractive features of multicomponent reactions, the protocol presented broad substrate scope, good functional group tolerance and mild reaction conditions. The utility of this procedure was further established by gram-scale synthesis as well as the diversified transformations of the products to useful compounds After reading the article, we found that the author used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Related Products of 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Related Products of 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jia, Qianfa; Yin, Guoliang; Lan, Yunfei; Lin, Yinhe; Ren, Qiao published an article in 2021. The article was titled 《Base-mediated Benzannulation Reactions for the Synthesis of Densely Functionalized Aryl α-Keto Esters》, and you may find the article in Asian Journal of Organic Chemistry.Category: nitriles-buliding-blocks The information in the text is summarized as follows:

A novel and straightforward strategy for the construction of versatile densely functionalized aryl α-keto esters were disclosed through a one-pot and efficient [4+2] benzannulation reaction of α-cyano-β-methylenones and ynediones, which were synthesized easily from the corresponding starting materials. This protocol featured high yield, mild metal-free reaction condition, high atom economy, high functional-group tolerance, easy handing and gram-scale synthesis. In the part of experimental materials, we found many familiar compounds, such as 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Category: nitriles-buliding-blocks)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Category: nitriles-buliding-blocks

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Recommanded Product: 3-Oxo-3-phenylpropanenitrileIn 2022 ,《Two-Step Construction of Thiophene-Oxazole Dyads with Fluorescent Properties by the Ring Expansion of Aziridines》 was published in Journal of Organic Chemistry. The article was written by Pankova, Alena S.. The article contains the following contents:

A general approach toward 2-thiophenyl substituted oxazoles using aziridination of a double bond of (acyl)alkenyl thiophenes with the subsequent expansion of the aziridine ring is developed. The isolation of intermediate aziridine is not necessary. This expedient protocol covers a broad scope of readily available 2-, 3-, and benzothiophene derivatives, is practical and reliable, requires short reaction times, and is simple to set up and work up reaction mixtures Thiophenyl-oxazoles, obtained by this method, exhibit fluorescence with high quantum yields. In the part of experimental materials, we found many familiar compounds, such as 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Recommanded Product: 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Recommanded Product: 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Metal-Free Visible-Light-Promoted Trifluoromethylation of Vinylcyclopropanes Using Pyrylium Salt as a Photoredox Catalyst》 was written by Chandu, Palasetty; Ghosh, Krishna Gopal; Sureshkumar, Devarajulu. Recommanded Product: 614-16-4This research focused onvinylcyclopropane trifluoromethylation pyrylium salt photoredox catalyst. The article conveys some information:

Visible-light-induced metal-free trifluoromethylation of activated, carbocyclic, and unactivated vinylcyclopropanes via a ring-opening reaction using the Langlois reagent (CF3SO2Na) is reported to synthesize allylic trifluoromethylated derivatives Allylic trifluoromethylation was achieved by a photooxidative single electron transfer (SET) process at an ambient temperature and under metal-free conditions and visible-light irradiation using pyrylium salt as a photoredox catalyst. The reported methodol. has an operational simplicity, broad substrate scope, high functional group tolerance, and scalability. In the experimental materials used by the author, we found 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Recommanded Product: 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Recommanded Product: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Name: 3-Oxo-3-phenylpropanenitrileIn 2019 ,《Synthesis and DNase I inhibitory properties of some 4-thiazolidinone derivatives》 was published in Journal of Cellular Biochemistry. The article was written by Kolarevic, Ana; Ilic, Budimir S.; Kocic, Gordana; Dzambaski, Zdravko; Smelcerovic, Andrija; Bondzic, Bojan P.. The article contains the following contents:

Twelve new thiazolidinones were synthesized and, together with 41 previously synthesized thiazolidinones, evaluated for inhibitory activity against DNase I (DNase I) in vitro. Ten compounds inhibited com. bovine pancreatic DNase I with an IC50 below 200 μM and showed to be more potent DNase I inhibitors than crystal violet (IC50 = 365.90 ± 47.33 μM), used as a pos. control. Moreover, three compounds were active against DNase I in rat liver homogenate, having an IC50 below 200 μM. (3-Methyl-1,4-dioxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide (41) exhibited the most potent DNase I inhibition against both com. and rat liver DNase I with IC50 values of 115.96 ± 11.70 and 151.36 ± 15.85 μM, resp. Site Finder and mol. docking defined the thiazolidinones interactions with the most important catalytic residues of DNase I, including the H-acceptor interaction with residues His 134 and His 252 and/or H-donor interaction with residues Glu 39 and Asp 168. The three most active compounds against both com. and rat liver DNase I (31, 38, and 41) exhibited favorable physico-chem., pharmacokinetic, and toxicol. properties. These observations could be utilized to guide the rational design and optimization of novel thiazolidinone inhibitors. Thiazolidinones as novel DNase I inhibitors could have potential therapeutic applications due to the significant involvement of DNase I in the pathophysiol. of many disease conditions. In the experiment, the researchers used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Name: 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Name: 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Saidi, Lamia; Samet, Amira; Dammak, Thameur; Pillet, Sebastien; Abid, Younes published their research in Physical Chemistry Chemical Physics in 2021. The article was titled 《Down and up conversion luminescence of the lead-free organic metal halide material: (C9H8NO)2SnCl6·2H2O》.HPLC of Formula: 614-16-4 The article contains the following contents:

The present work deals with the optical properties of hybrid organic metal halide material namely (C9H8NO)2SnCl6.2H2O. Its structure is built up from isolated [SnCl6]2- octahedral dianions surrounded by Hydroxyl quinolinium organic cations (C9H8NO)+, abbreviated as [HQ]+. Unlike the usual hybrid materials, where metal halide ions are luminescent semiconductors while the organic ones are optically inactive, [HQ]2SnCl6.2H2O contains two optically active entities: [HQ]+ organic cations and [SnCl6]2- dianions. The optical properties of the synthesized crystals were studied by optical absorption spectroscopy, photoluminescence measurements and DFT calculations of electronic d. of states. These studies have shown that both organic and inorganic entities have very close HOMO-LUMO gaps and very similar band alignments favoring the resonant energy transfer process. In addition, measurements of luminescence under variable excitations reveal an intense green luminescence around 497 nm under UV excitation (down conversion) and IR excitation (up conversion luminescence). The down conversion luminescence is assigned to the π-π* transition within the [HQ]+ organic cations involving charge transfer between the organic and inorganic entities, whereas the up-conversion luminescence is based on the triplet-triplet annihilation mechanism (TTA). The experimental part of the paper was very detailed, including the reaction process of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4HPLC of Formula: 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.HPLC of Formula: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Salaverri, Noelia; Carli, Benedetta; Gratal, Patricia B.; Marzo, Leyre; Aleman, Jose published an article in Advanced Synthesis & Catalysis. The title of the article was 《Remote Giese Radical Addition by Photocatalytic Ring Opening of Activated Cycloalkanols》.Application In Synthesis of 3-Oxo-3-phenylpropanenitrile The author mentioned the following in the article:

The addition of these remote alkyl radicals RC(R1)(R2)OH [R = Me, 4-methoxyphenyl, furan-2-yl, etc.; R1R2 = -(CH2)5-, -CH2S(CH2)2-, -CH2N(Boc)(CH2)3-, etc.] to electron deficient double bonds R3CH=C(R4)CN (R3 = Ph, thiophen-2-yl, naphthalen-1-yl, etc.; R4 = CN, C(O)Ph, 4-nitrophenyl, etc.) under photoorganocatalyzation and very mild conditions was reported. The method not only applicable to diactivated double bonds, but monoactivated ones are also accessible using more stabilized alkyl radicals, and alkyl chains of any length can be introduced. The final products RC(O)(CH2)nCH2C(R3)CH(R4)CN (n = 2, 4, 6, etc.) can be easily converted into more complex structures via a one-pot process, and the activating functional groups were transformed in the more versatile Me esters. Mechanistic investigations support a mechanistic proposal based on a PCET process. After reading the article, we found that the author used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Application In Synthesis of 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Application In Synthesis of 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts