Category: 614-16-4

In 2022,Jacob, Raquel G.; Hartwig, Daniela; Nascimento, Jose Edmilson R.; Abib, Paola B.; Ebersol, Camila P.; Nunes, Pamela P. P.; Birmann, Paloma T.; Casaril, Angela M.; Savegnago, Lucielli; Schumacher, Ricardo F. published an article in Tetrahedron Letters. The title of the article was 《Sequential one-pot synthesis and antioxidant evaluation of 5-amino-4-(arylselanyl)-1H-pyrazoles》.Name: 3-Oxo-3-phenylpropanenitrile The author mentioned the following in the article:

A simple and efficient method for the sequential one-pot synthesis of 5-amino-4-(arylselanyl)-1H-pyrazoles catalyzed by CuI/bpy under mild conditions was described. The starting materials were easily available benzoylacetonitriles, substituted hydrazines and diaryl diselenides. A range of substituted 5-amino-4-(arylselanyl)-1H-pyrazoles was obtained in moderate to good yields (49% to 90%). Moreover, the antioxidant effect of the 5-amino-4-(arylselanyl)-1H-pyrazoles were reported in several in-vitro trials, which is extremely important, because oxidative stress is a crucial role in the development of various human diseases. This data revealed that all compounds demonstrated promising effects in scavenging the synthetic radical ABTS+, presented reducing power in ferric ion reducing antioxidant power (FRAP) assay, and ability to inhibit linoleic acid peroxidation Thus, these compounds can be interesting synthetic mols. in the protection from oxidative diseases. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Name: 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Name: 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Access to pyridines via cascade nucleophilic addition reaction of 1,2,3-triazines with activated ketones or acetonitriles》 was written by Zhang, Yuan; Luo, Han; Lu, Qixing; An, Qiaoyu; Li, You; Li, Shanshan; Tang, Zongyuan; Li, Baosheng. HPLC of Formula: 614-16-4This research focused ontriazine acetonitrile tandem regioselective cycloaddition nucleophilic addition; ketone triazine tandem regioselective cycloaddition nucleophilic addition; pyridine preparation. The article conveys some information:

The cascade nucleophilic addition reactions of 1,2,3-triazines with activated acetonitriles or ketones, which were used to construct highly substituted pyridines that were not easily accessed by conventional methods was reported. The strategy addressed some structural diversity issues currently facing medicinal chem., and the resulting pyridines was used as convenient precursors for the synthesis of related pharmaceuticals. This method was applied to the syntheses of the marketed drug etoricoxib and several biol. important mols. in a few steps. In addition to this study using 3-Oxo-3-phenylpropanenitrile, there are many other studies that have used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4HPLC of Formula: 614-16-4) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.HPLC of Formula: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Metal-Free Solvent/Base-Switchable Divergent Synthesis of Multisubstituted Dihydrofurans》 was written by Gore, Babasaheb Sopan; Kuo, Chiao-Ying; Garkhedkar, Amol Milind; Chang, Yu-Lun; Wang, Jeh-Jeng. Quality Control of 3-Oxo-3-phenylpropanenitrile And the article was included in Organic Letters in 2020. The article conveys some information:

A general protocol for the synthesis of multisubstituted 2,3-dihydrofuran-2-carbonitriles and 4,5-dihydrofuran-3-carbonitriles was demonstrated under a metal-free regime with the same oxidant, TBHP. By simply switching the reaction solvent and base, the reaction proceeds via two pathways. An unexpected -CN group migration rearrangement and hydroxylation have occurred in nonpolar and polar solvents, resp., under the reported conditions. Furthermore, the source of the hydroxyl group and hydrogen in the reaction is indirectly confirmed with isotope labeling studies. In addition to this study using 3-Oxo-3-phenylpropanenitrile, there are many other studies that have used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Quality Control of 3-Oxo-3-phenylpropanenitrile) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Quality Control of 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《De Novo Protocol for the Construction of Benzo[a]fluorenes via Nitrile/Alkene Activation》 was written by Gore, Babasaheb Sopan; Chiang, Chun-Hsien; Lee, Chein Chung; Shih, Yi-Lun; Wang, Jeh-Jeng. Application of 614-16-4 And the article was included in Organic Letters in 2020. The article conveys some information:

Unprecedented chemo- and regioselective synthesis of benzo[a]fluorenes and naphthamide-substituted benzo[a]fluorenes were constructed from the reaction of (E)-2-aroyl-3-(2-(arylalkynes/alkenes)aryl)acrylonitrile scaffolds under metal-free conditions via the activation of nitriles and alkenes, resp. A tentative reaction mechanism was proposed for this homofunctionalization of nitriles. Control experiments showed that the reaction proceeds via selective nitrile or alkene protonation, depending upon the substrates. Addnl., we demonstrated an alternative expeditious route for the synthesis of disubstituted benzo[a]fluorenes in the presence of TfOH alone. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Application of 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Application of 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Synthesis and in-vitro anti-proliferative evaluation of some pyrazolo[1,5-a]pyrimidines as novel larotrectinib analogs》 was published in Bioorganic Chemistry in 2020. These research results belong to Attia, Mohamed H.; Elrazaz, Eman Z.; El-Emam, Soad Z.; Taher, Azza T.; Abdel-Aziz, Hatem A.; Abouzid, Khaled A. M.. Quality Control of 3-Oxo-3-phenylpropanenitrile The article mentions the following:

A series of pyrazolo[1,5-a]pyrimidine-3-carbonitriles I [R = H; Ar = 2-furanyl, Ph, 2-naphthalenyl, etc.] and pyrazolo[1,5-a]pyrimidine-3,6-dicarbonitriles I [R = cyano; Ar = 2-furanyl, Ph, 4-methoxyphenyl] was synthesized by the reaction of 5-amino-3-phenyl-1H-pyrazole-4-carbonitrile with 3-(dimethylamino)-1-arylprop-2-en-1-ones or 2-aryl-3-(dimethylamino)acrylonitriles, resp. In addition, 7-amino-5-oxo-2-phenyl-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile II was prepared from the reaction of dimethylformamide-dimethylacetal with Et cyanoacetate. The anticancer activity of the newly synthesized compounds against Huh-7, HeLa, MCF-7 and MDA-MB231 cell lines showed moderate activity of compound I [R = H, Ar = 4-chlorophenyl] as anti-proliferative agent against Huh-7 cell line with IC50 = 6.3μM when compared with doxorubicin (IC50 = 3.2μM). On the other hand, compound I [R = cyano, Ar = 4-methoxyphenyl] revealed potent anti-proliferative activity against HeLa cell line with IC50 = 7.8μM when compared with doxorubicinι (IC50 = 8.1μM). Also compound I [R = H, Ar = 2-naphthalenyl] exhibited a promising anti-proliferative activity against MCF-7 cell line (IC50 = 3.0μM) whereas IC50 of doxorubicin = 5.9μM, finally compounds I [R = H, Ar = 2-naphthalenyl] and I [R = cyano, Ar = 24-methoxyphenyl] have potent activity as anti-proliferative agents against MDA-MB231 cell line with IC50 = 4.32 and 5.74μM, resp. when compared with doxorubicin (IC50 = 6.0μM). The experimental part of the paper was very detailed, including the reaction process of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Quality Control of 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Quality Control of 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

SDS of cas: 614-16-4In 2019 ,《Chemo- and Diastereoselective Synthesis of Pyrazolo-tetrahydropyridines via Multicomponent Sequential Aza-Diels-Alder Reactions in Water》 appeared in ChemistrySelect. The author of the article were Nazeri, Mohammad Taghi; Javanbakht, Siamak; Shaabani, Ahmad; Khavasi, Hamid Reza. The article conveys some information:

A novel and an efficient strategy for the synthesis of chemo- and diastereoselective synthesis of pyrazolo-tetrahydropyridines I [X = O, NMe; Y = C, SO; R1 = Me, Ph; R2 = H, Br, OMe, naphthyl; Ar = Ph, 4-ClC6H4] via a one-pot multi-component intramol. aza-Diels-Alder reactions (ADARs) from benzoylacetonitrile derivatives, phenylhydrazine, salicylaldehyde derivatives, and styrenesulfonyl or cinnamoyl chloride in H2O as a green solvent was reported. This synthesis procedure was also designed to follow the group-assisted purification (GAP) chem., which could avoid traditional purification such as recrystallization and chromatog. methods.3-Oxo-3-phenylpropanenitrile(cas: 614-16-4SDS of cas: 614-16-4) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.SDS of cas: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ibrahim, Seham A.; Fayed, Eman A.; Rizk, Hala F.; Desouky, Said E.; Ragab, Ahmed published an article in 2021. The article was titled 《Hydrazonoyl bromide precursors as DHFR inhibitors for the synthesis of bis-thiazolyl pyrazole derivatives; antimicrobial activities, antibiofilm, and drug combination studies against MRSA》, and you may find the article in Bioorganic Chemistry.Formula: C9H7NO The information in the text is summarized as follows:

Microbial resistance is a big concern worldwide, making the development of new antimicrobial drugs difficult. The thiazole and pyrazole rings are important heterocyclic compounds utilized to produce a variety of antimicrobial medications. As a result, a series of new bis-thiazolyl-pyrazole derivatives 3, 4a-c, 5a, b, and 6a-c was synthesized by reacting bis hydrazonoyl bromide with several active methylene reagents in a one-pot reaction. The assigned structure was characterized entirely based on elemental and spectral analyses. The antimicrobial activity represented by MIC was performed using a resazurin-based turbidimetric (TB) assay. The results exhibited good antimicrobial activity against gram-pos. strains, especially S. aureus (ATCC6538) while showing poor to moderate activity against gram-neg. and fungal strains. Furthermore, the most active derivatives 3, 4a, 4c, and 5b were evaluated for MIC, MBC, antibiofilm, hemolytic assay, and drug combination testing against two S. aureus (ATCC6538) and MRSA (ACL18) strains. Addnl., bis-thiazolyl pyrazole 3, 4c, and 5b exhibited more potent inhibitory activity for DHFR with IC50 values (6.34 ± 0.26, 7.49 ± 0.28, and 3.81 ± 0.16 μM), resp., compared with Trimethoprim (8.34 ± 0.11 μM). The bis-1-(substituted-thiazol-2-yl)-1H-pyrazole-4-carbonitrile derivative 5b was the most active member with MIC values ranging from (0.12-0.25 μM) compared to Vancomycin (1-2 μM), and MBC values ranging from (0.5-1 μM) for S. aureus (ATCC6538) and MRSA (ACL18). Surprisingly, compound 5b displayed bactericidal behavior, synergistic effect with three com. antibiotics, and inhibited DHFR with 2.1 folds higher than Trimethoprim. Finally, good findings were obtained from in silico investigations incorporating toxicity prediction and mol. docking simulation. In the experimental materials used by the author, we found 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Formula: C9H7NO)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Formula: C9H7NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hussein, Ahmad Q.; Sammor, Mervat S. published their research in Heterocyclic Letters in 2021. The article was titled 《New easy one-pot synthetic routes of 2-arylbenzimidazoles》.Synthetic Route of C9H7NO The article contains the following contents:

One-pot condensation of 1,2-phenylenediamine with phenacyl cyanides affords high yields of the corresponding 2-arylbenzimidazoles. The same products are also obtained through similar condensation of phenylenediamine either with phenacyl thiocyanates or with benzylidenemalononitriles. In the experimental materials used by the author, we found 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Synthetic Route of C9H7NO)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Synthetic Route of C9H7NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《IBX-Promoted Oxidative Cyclization of N-Hydroxyalkyl Enamines: A Metal-Free Approach toward 2,3-Disubstituted Pyrroles and Pyridines》 was written by Gao, Peng; Chen, Huai-Juan; Bai, Zi-Jing; Zhao, Mi-Na; Yang, Desuo; Wang, Juan; Wang, Ning; Du, Lele; Guan, Zheng-Hui. Category: nitriles-buliding-blocks And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

An iodoxybenzoic acid-mediated selected oxidative cyclization of N-hydroxyalkyl enamines was developed. Through this strategy, a variety of 2,3-disubstituted pyrroles and pyridines were produced in good selectivity involving oxidation of alc., followed by condensation of aldehyde and α-C of enamines. Furthermore, this metal-free method has several advantages, including the use of environmentally friendly reagents, broad substrate scope, mild reaction conditions, and high efficiency.3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Category: nitriles-buliding-blocks) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Indium(III)chloride catalyzed synthesis of novel 1H-pyrazolo[1,2-b]phthalazine-5,10-diones and 1H-pyrazolo[1,2-a]pyridazine-5,8-diones under solvent-free condition》 were Jadhav, Amol Maruti; Balwe, Sandip Gangadhar; Kim, Jong Su; Lim, Kwon Taek; Jeong, Yeon Tae. And the article was published in Tetrahedron Letters in 2019. Name: 3-Oxo-3-phenylpropanenitrile The author mentioned the following in the article:

An efficient, inexpensive and environmentally friendly synthesis of novel 3-amino-2-benzoyl-1-aryl-1H-pyrazolo[1,2-b]phthalazine-5,10-dione and 3-amino-2-benzoyl-1-aryl-1H-pyrazolo[1,2-a]pyridazine-5,8-dione derivatives were developed via one-pot three-component reaction of phthalhydrazide or maleic hydrazide, aryl aldehydes and substituted benzoylacetonitriles in the presence of catalytic amount of InCl3 as a Lewis acid catalyst under solvent-free conditions. A mild reaction conditions, short reaction times, high yields and a wide range of functional group tolerance were the most important features of this protocol. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Name: 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Name: 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts