Category: 614-16-4

In 2019,ACS Combinatorial Science included an article by Zhang, Mo; Chen, Meng-Nan; Li, Jiao-Mian; Liu, Nan; Zhang, Zhan-Hui. Recommanded Product: 3-Oxo-3-phenylpropanenitrile. The article was titled 《Visible-Light-Initiated One-Pot, Three-Component Synthesis of 2-Amino-4H-pyran-3,5-dicarbonitrile Derivatives》. The information in the text is summarized as follows:

A novel approach for the visible-light-initiated synthesis of 2-amino-4H-pyran-3,5-dicarbonitrile derivatives via a one-pot, three-component reaction of aldehydes or isatins, malononitrile, and α-cyano ketones was developed. The reaction was carried out at room temperature in ethanol/water to give the corresponding products with a wide range of functional groups in high yields. This process did not require any additives or chromatog. separation and could be applied for gram-scale synthesis. In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Recommanded Product: 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Recommanded Product: 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Buravchenko, Galina I.; Scherbakov, Alexander M.; Dezhenkova, Lyubov G.; Monzote, Lianet; Shchekotikhin, Andrey E. published their research in RSC Advances in 2021. The article was titled 《Synthesis of 7-amino-6-halogeno-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides: a way forward for targeting hypoxia and drug resistance of cancer cells》.SDS of cas: 614-16-4 The article contains the following contents:

To establish a new approach for the synthesis of quinoxaline 1,4-dioxides as hypoxia-selective cytotoxic agents, an original multi-step preparation of derivatives possessing the diamine moiety at position 7 was evaluated. Herein, we present the synthesis of a series of novel 7-amino-6-halogeno-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides 13a-h, 14a,b,g based on the regioselective Beirut reaction. Comparison of antitumor properties of derivatives possessing the diamine moiety at position 7 with structurally close congeners possessing the corresponding amino groups at position 6 revealed key differences in the cytotoxicity profiles and HIF-1α inhibition. All the synthesized 7-amino-6-halogeno derivatives 13a-h, 14a,b,g demonstrated significant cytotoxic activities against breast cancer cell lines (MCF7, MDA-MB-231) in normoxia and hypoxia with IC50 values ranging from 0.1 to 7.6 μM. Most of these novel derivatives can circumvent the multidrug resistance of tumor cells caused by P-glycoprotein over expression. The lead compounds 13a, 14a and 14b can suppress the expression of HIF-1α at low micromolar concentrations and induce apoptosis in breast cancer MCF7 cells. In addition, compound 14b effectively inhibits BCL2 and ERα expression in MCF7 cells. The current research opens a new direction for targeting hypoxia and drug resistance of cancer cells.3-Oxo-3-phenylpropanenitrile(cas: 614-16-4SDS of cas: 614-16-4) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.SDS of cas: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Tetrahedron included an article by Balwe, Sandip Gangadhar; Kim, Jong Su; Kim, Yeong-Il; Jeong, Yeon Tae. Synthetic Route of C9H7NO. The article was titled 《Diversity-oriented one-pot synthesis of furan based densely substituted biheteroaryls via isocyanide insertion》. The information in the text is summarized as follows:

A facile and efficient acid-catalyzed cascade reaction for the synthesis of novel biheteroaryl structural motifs containing densely functionalized furans has been developed. The reaction sequence involves a Knoevenagel condensation of arylglyoxals with aroyl or heteroaroylacetonitrile and subsequently an isocyanide insertion via formal [4+1] cycloaddition followed by rapid [1,3]-H shift to afford uniquely decorated novel biheterocycles, e.g., I. Furthermore, the scope of the methodol. was extended to diverse biheteroaryls by employing 3-(2-furyl)-3-oxopropanenitrile, 3-cyanoacetyl-1-methylindole, 3-oxo-3-(1H-pyrrol-2-yl)propanenitrile, 3-(1H-indol-3-yl)-3-oxopropanenitrile, 3-oxo-3-(2-thienyl)propionitrile and benzoylacetonitriles. In addition to this study using 3-Oxo-3-phenylpropanenitrile, there are many other studies that have used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Synthetic Route of C9H7NO) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Synthetic Route of C9H7NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Chinese Chemical Letters included an article by Zhou, Chao; Diao, Pinhui; Li, Xiaoji; Ge, Yanqin; Guo, Cheng. Formula: C9H7NO. The article was titled 《Facile photochemical synthesis of α-ketoamides and quinoxalines from amines and benzoylacetonitrile under mild conditions》. The information in the text is summarized as follows:

A selective protocol for the synthesis of either α-ketoamides or quinoxaline derivatives under the same reaction conditions was achieved simply by varying substitution number of amino-groups. The method features metal-free, room temperature and broad substrate scope as well as no extra oxidant. This process applied to various substituent groups and provided products in moderate to good yield. Finally, a rational mechanism was proposed.3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Formula: C9H7NO) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Formula: C9H7NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Alizadeh, Abdolali; Rostampoor, Azar published an article in ChemistrySelect. The title of the article was 《Efficient One Pot and Chemoselective Synthesis of Polysubstituted Dihydro-6H-chromeno[4,3-d]pyrazolo[1,5-a]pyrimidin-6-ones via a Four-Component Reaction》.Safety of 3-Oxo-3-phenylpropanenitrile The author mentioned the following in the article:

In this research, a simple and chemoselective synthesis of highly fluorescent polysubstituted dihydro-6H-chromeno[4,3-d]pyrazolo[1,5-a]pyrimidin-6-ones containing one chiral stereocenter was presented by a sequential four-component reaction of 4-chloro-3-formylcoumarin, 1-phenyl-2-(1,1,1-triphenyl-λ5-phosphanylidene)ethan-1-ones (Wittig reagent), benzoylacetonitriles and hydrazine hydrate as readily available starting materials, which includes base-mediated 1,4-addition/aza-Michael addition/formation of two C-N bonds. The desired products were obtained with short reaction times, easy purification (products can be purified by washing with EtOH), and medium to high yields (up to 92%) under relatively mild reaction conditions. Mol. structures were determined by IR spectrophotometry, mass spectrometry, NMR spectroscopy, and single-crystal X-ray anal. In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Safety of 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Safety of 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Murali, Karunanidhi; Prasad, Karnam Jayarampillai Rajendra published an article in ChemistrySelect. The title of the article was 《A Direct and Divergent Entrance to Aza Heterocycles On 3-Amino Carbazole》.Product Details of 614-16-4 The author mentioned the following in the article:

The product-switchable reagent-controlled construction of 1,4-Dihydropyridines and stereo-structured amino dienes decorated with carbazole moieties have been realized via coupling of 3-amino-9-ethylcarbazole with benzaldehyde and Me propiolate. Highly functionalized pyrido[3,2-b]carbazoles have been concisely synthesized in good yields via Et3N promoted single-pot assembly of 3-amino-9-ethylcarbazole with aryl/heteroaryl aldehydes and α-aryl-3-oxopropanenitrile. The structures of the synthesized products were confirmed by spectral data and elemental anal. In the experiment, the researchers used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Product Details of 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Product Details of 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Inorganic Chemistry included an article by Hiscock, Lana K.; Joekar, Delara; Balonova, Barbora; Tomas Piqueras, Marta; Schroeder, Zachary W.; Jarvis, Victoria; Maly, Kenneth E.; Blight, Barry A.; Dawe, Louise N.. HPLC of Formula: 614-16-4. The article was titled 《Structures, Phase Behavior, and Fluorescent Properties of 3-Phenyl-1-(pyridin-2-yl)-1H-pyrazol-5-amine and Its ZnCl2 Complex》. The information in the text is summarized as follows:

The synthesis of the asym. ligand 3-phenyl-1-(pyridin-2-yl)-1H-pyrazol-5-amine (L1) and its single-crystal X-ray structure are reported. L1 displays crystallog. symmetry (orthorhombic, Pccn) higher than its mol. symmetry (point group C1) and also displays supercooling, with a difference in the melting and solidification points of over 100°C. Upon complexation with ZnCl2, L1 engages in both primary cation and secondary anion coordination via hydrogen bonding, and the complex exhibits a room-to-low-temperature single crystal-to-crystal phase transition. The ZnCl2 complex becomes a birefringent fluid mixed with crystalline domains at high temperatures, as detected by polarized optical microscopy. Examination of the photoluminescence properties showed that the emission intensity increased and a pronounced bathochromic shift was observed in the emission maximum upon going from solution to the solid state, for both the ligand and complex, consistent with aggregation-induced emission behavior. The syntheses and single-crystal structures of 3-phenyl-1-(pyridin-2-yl)-1H-pyrazol-5-amine (L1) and its complex with ZnCl2 are reported. L1 exhibits supercooling, with a difference in the melting and solidification points of over 100°C. The complex [L1ZnCl2] has a room-to-low-temperature single crystal-to-crystal phase transition in the solid state, while a birefringent fluid phase mixed with crystalline domains is present at high temperatures Significant fluorescence enhancement is observed upon formation of the ZnCl2 complex. The experimental part of the paper was very detailed, including the reaction process of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4HPLC of Formula: 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.HPLC of Formula: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Microwave synthesis of 1-aryl-1H-pyrazole-5-amines》 were Everson, Nikalet; Yniguez, Kenya; Loop, Lauren; Lazaro, Horacio; Belanger, Briana; Koch, Grant; Bach, Jordan; Manjunath, Aashrita; Schioldager, Ryan; Law, Jarvis; Grabenauer, Megan; Eagon, Scott. And the article was published in Tetrahedron Letters in 2019. COA of Formula: C9H7NO The author mentioned the following in the article:

A microwave-mediated synthesis of 1H-pyrazole-5-amines utilizing 1 M HCl at 150 °C was developed in order to provide products in a matter of minutes with minimal purification Most reactions are complete in only 10 min and can be isolated via a simple filtration without the need for further purification by column chromatog. or recrystallization This method tolerates a range of functional groups and can be performed on milligram to gram scales. In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4COA of Formula: C9H7NO)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.COA of Formula: C9H7NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Synthesis and structure of dialkyl (Z)-3-amino-2-cyano-4-diazopent-2-enedioates》 was published in Monatshefte fuer Chemie in 2020. These research results belong to Yavari, Issa; Mohsenzadeh, Ramin; Kayanian, Jasmine. Formula: C9H7NO The article mentions the following:

Diazo-transfer reaction of tosyl azide and alkyl 2-cyanoacetates in the presence of pyridine at 0° gives the corresponding alkyl 2-cyano-2-diazoacetates. This material readily underwent nucleophilic attack by pyridinium 1-cyano-2-alkoxy-2-oxoethan-1-ide to form dialkyl (Z)-3-amino-2-cyano-4-diazopent-2-enedioates. The X-ray structure of a typical product is reported, as well as DFT computational studies that illuminate the structural features of these stable diazo compounds The results came from multiple reactions, including the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Formula: C9H7NO)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Formula: C9H7NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gao, Na; Liu, Xiaoyu; Yuan, Xu; Hu, Bingwei; Jiang, Peiyun; Lin, Jun; Jin, Yi published an article in 2022. The article was titled 《Oxidative [2 + 1 + 1 + 1] Annulation of Aldehydes and Methylene Nitriles: Synthesis of Diastereoselective Polysubstituted Cyclopentenes》, and you may find the article in Journal of Organic Chemistry.Application In Synthesis of 3-Oxo-3-phenylpropanenitrile The information in the text is summarized as follows:

Herein, a green cascade approach to prepare a variety of diastereoselective polysubstituted cyclopentene derivatives through metal-free oxidative [2 + 1 + 1 + 1] annulation of aldehydes and methylene nitriles were reported. Mechanistic studies demonstrated that the reaction underwent a four-step cascade reaction including air oxidation and Michael addition to obtain the final product. This reaction features readily available starting materials, transition metal-free, eco-friendly operations, gram-scale syntheses, and wide functional group tolerance. The methodol. may be useful for the construction of polysubstituted cyano-cyclopentene heterocycles with potential biol. activity. The experimental part of the paper was very detailed, including the reaction process of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Application In Synthesis of 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Application In Synthesis of 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts