Category: 614-16-4

In 2022,Jia, Fan; He, Jing; Wei, Yueting; Liu, Yan; Gu, Yanlong; Vaccaro, Luigi; Liu, Ping published an article in Molecular Catalysis. The title of the article was 《C4-Sulfenylation of 4-iodine-1H-pyrazole-5-amine with arylsulfonyl hydrazide in water》.Category: nitriles-buliding-blocks The author mentioned the following in the article:

A C4-sulfenylation of 4-iodine-1H-pyrazole-5-amine with arylsulfonyl hydrazide in water was developed. A series of C4-sulfenylated products I [R = t-Bu, Ph, 4-ClC6H4, etc.; Ar = Ph, 4-MeC6H4, 3-BrC6H4, etc.] were obtained in moderate to excellent yields. This protocol featured green reaction conditions (metal-free, water as the solvent, in the air), odorless and easily available sulfur reagent, broad substrate scope as well as gram-scale synthesis. Mechanistic studies showed that the in-situ formation of iodine from 4-iodine-1H-pyrazole-5-amine in the presence of aryl sulfonyl hydrazides was the key to the C4-Sulfenylation. After reading the article, we found that the author used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Category: nitriles-buliding-blocks)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Electrochemical Synthesis of β-Ketonitriles from Aryl Methyl Ketones》 was written by Yavari, Issa; Shaabanzadeh, Sina; Sheikhi, Sara. Recommanded Product: 614-16-4 And the article was included in ChemistrySelect in 2020. The article conveys some information:

A synthesis of β-ketonitriles ArC(O)CH2CN (Ar = Ph, 4-chlorophenyl, naphthalen-2-yl, etc.) by cyanation of aryl Me ketones ArC(O)CH3 with two completely distinct sources of cyanide, namely Me3SiCN and KCN, under metal- and oxidant-free electrochem. anodic oxidation conditions is described. In this approach, a range of β-ketonitriles can be obtained in good yields. This conversion is facilitated by I2, generated in situ from electrochem. oxidation of iodide ion to afford the β-ketonitriles. This environmentally benign method is more convenient and practical compared to previous approaches. In the part of experimental materials, we found many familiar compounds, such as 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Recommanded Product: 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Recommanded Product: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Upadhyay, Rahul; Kumar, Shashi; Maurya, Sushil K. published their research in ChemCatChem in 2021. The article was titled 《V2O5@TiO2 Catalyzed Green and Selective Oxidation of Alcohols, Alkylbenzenes and Styrenes to Carbonyls》.HPLC of Formula: 614-16-4 The article contains the following contents:

The versatile application of different functional groups such as alcs. (1° and 2°), alkyl arenes, and (aryl)olefins to construct carbon-oxygen bond via oxidation is an area of intense research. Here, a reusable heterogeneous V2O5@TiO2 catalyzed selective oxidation of various functionalities utilizing different mild and eco-compatible oxidants under greener reaction conditions has been reported. The method was successfully applied for the alc. oxidation, oxidative scission of styrenes, and benzylic C-H oxidation to their corresponding aldehydes and ketones. The utilization of mild and eco-friendly oxidizing reagents such as K2S2O8, H2O2 (30% aqueous), TBHP (70% aqueous), broad substrate scope, gram-scale synthesis, and catalyst recyclability are notable features of the developed protocol. In the experiment, the researchers used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4HPLC of Formula: 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.HPLC of Formula: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Iron-catalyzed cross-dehydrogenative coupling of indolin-2-ones with active methylenes for direct carbon-carbon double bond formation》 was written by Tan, Zhi-Yu; Wu, Ke-Xin; Huang, Lu-Shan; Wu, Run-Shi; Du, Zheng-Yu; Xu, Da-Zhen. Name: 3-Oxo-3-phenylpropanenitrile And the article was included in Green Chemistry in 2020. The article conveys some information:

The iron-catalyzed cross-dehydrogenative coupling (CDC) of C(sp3)-H/C(sp3)-H bonds to afford olefins by 4H elimination is described. This method employs air (mol. oxygen) as an ideal oxidant, and is performed under mild, ligand-free and base-free conditions. H2O is the only byproduct. Good tolerance of functional groups and high yields have also been achieved. Preliminary mechanistic investigations suggest that the present transformation involves a radical process. The results came from multiple reactions, including the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Name: 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Name: 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Computed Properties of C9H7NOIn 2020 ,《Transition metal-free cyclization of N-Boc-N-propargylenamines》 appeared in Heterocycles. The author of the article were Chikayuki, Yuya; Kouno, Yasuaki; Yonekawa, Shiori; Ishikawa, Haruka; Waki, Yoko; Teramoto, Hiroyoshi; Sasaki, Shigeru; Higashiyama, Kimio; Yamauchi, Takayasu. The article conveys some information:

An efficient method for the synthesis of multi-substituted pyrroles was developed using basic cyclization of readily accessible N-Boc-N-propargylenamines. Despite the basic conditions, cleavage of the N-Boc group occurred easily. The process was rapid and afforded N-H-pyrroles with wide functional group tolerance in high yields. After reading the article, we found that the author used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Computed Properties of C9H7NO)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Computed Properties of C9H7NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Synthesis, ellipsometry and non-linear optical features of substituted 1,3,5-triphenylpyrazolines》 was written by Gondek, Ewa; Niziol, Jacek; Danel, Andrzej; Kucharek, Mateusz; Jedryka, Jaroslaw; Karasinski, Pawel; Nosidlak, Natalia; Fedorchuk, Andrij A.. Safety of 3-Oxo-3-phenylpropanenitrileThis research focused ontriphenylpyrazoline dye synthesis ellipsometry nonlinear optical property. The article conveys some information:

Ellipsometric and nonlinear optical properties of new, differently substituted, 1,3,5-triphenylpyrazolines dyes, were studied. Results of theor. calculation within a framework of d. functional theory (DFT) technique were verified by spectroscopic ellipsometry and optical second harmonic generation (SHG) experiment at fundamental laser wavelength 1064 nm. Absorption bands and complex refractive indexes were determined Principal role of 2-thienyl substituent for first order nonlinear optical properties was demonstrated. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Safety of 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Safety of 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lin, Yamei; Bu, Qingxia; Xu, Jiaxian; Liu, Xiao; Zhang, Xueping; Lu, Guo-Ping; Zhou, Baojing published their research in Molecular Catalysis in 2021. The article was titled 《Hf-MOF catalyzed Meerwein-Ponndorf-Verley (MPV) reduction reaction: Insight into reaction mechanism》.HPLC of Formula: 614-16-4 The article contains the following contents:

Hf-MOF-808 exhibits excellent activity and specific selectivity on the hydrogenation of carbonyl compounds via a hydrogen transfer strategy. Its superior activity than other Hf-MOFs is attributed to its poor crystallinity, defects and large sp. surface area, thereby containing more Lewis acid-base sites which promote this reaction. D. functional theory (DFT) computations are performed to explore the catalytic mechanism. The results indicate that alc. and ketone fill the defects of Hf-MOF to form a six-membered ring transition state (TS) complex, in which Hf as the center of Lewis stearic acid coordinates with the oxygen of the substrate mol., thus effectively promoting hydrogen transfer process. Other reactive groups, such as -NO2, C = C, -CN, of inadequate hardness or large steric hindrance are difficult to coordinate with Hf, thus weakening their catalytic effect, which explains the specific selectivity Hf-MOF-808 for reducing the carbonyl group. The experimental part of the paper was very detailed, including the reaction process of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4HPLC of Formula: 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.HPLC of Formula: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Category: nitriles-buliding-blocksIn 2019 ,《Synthesis and biological evaluation of 7-(aminoalkyl)pyrazolo[1,5-a]pyrimidine derivatives as cathepsin K inhibitors》 appeared in Bioorganic Chemistry. The author of the article were Petek, Nejc; Stefane, Bogdan; Novinec, Marko; Svete, Jurij. The article conveys some information:

A series of novel 7-aminoalkyl substituted pyrazolo[1,5-a]pyrimidine derivatives were synthesized and tested for inhibition of cathepsin K. The synthetic methodol. comprises cyclization of 5-aminopyrazoles with N-Boc-α-amino acid-derived ynones followed by transformation of the ester and the Boc-amino functions. It allows for easy diversification of the pyrazolo[1,5-a]pyrimidine scaffold at various positions. Mol. docking studies with pyrazolo[1,5-a]pyrimidine derivatives were also performed to elucidate the binding mode in the active site of cathepsin K. The synthesized compounds exhibited moderate inhibition activity (Ki ≥ 77 μM). In the experiment, the researchers used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Category: nitriles-buliding-blocks)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Organic Letters included an article by Nagaraju, Sakkani; Liu, Shuhua; Liu, Jinggong; Yang, Shuang; Liu, Rui; Chen, Zhizhou; Paplal, Banoth; Fang, Xinqiang. Related Products of 614-16-4. The article was titled 《Regioselectivity-Switchable Catalytic Annulations of Alkynyl α-Diketones and α-Cyanoketones》. The information in the text is summarized as follows:

Regioselectivity-switchable reactions hold irreplaceable importance in the construction of diversified architectures. In this work, Bronsted base-catalyzed regioselectivity-switchable annulations between alkynyl α-diketones and α-cyanoketones have been achieved for the first time, delivering a series of skeletally thoroughly different dihydrofurofuran and furan derivatives A range of novel transformations of the products can be realized. The work also demonstrates the unique features of alkynyl α-diketone chem., which are in sharp contrast to the current understanding of ynone-related chem. In the experimental materials used by the author, we found 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Related Products of 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Related Products of 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,ChemistrySelect included an article by Vaarla, Krishnaiah; Karnewar, Santosh; Panuganti, Devayani; Peddi, Saikiran Reddy; Vedula, Rajeswar Rao; Manga, Vijjulatha; Kotamraju, Srigiridhar. Product Details of 614-16-4. The article was titled 《3-(2-(5-Amino-3-aryl-1H-pyrazol-1-yl)thiazol-4-yl)-2H-chromen-2-ones as Potential Anticancer Agents: Synthesis, Anticancer Activity Evaluation and Molecular Docking Studies》. The information in the text is summarized as follows:

In an effort to design and develop efficient anticancer agents here, the synthesis, anticancer activity and mol. docking studies of new 3-(2-(5 amino-3-aryl-1H-pyrazol-1-yl)thiazol-4-yl)-2H-chromen-2-ones I (R = H, Cl, OCH3 etc.; R1 = H, Cl, Br, etc.; R2 = H, Br, C6H5) is reported. The target products were synthesized via a facile one pot multicomponent approach by utilizing various substituted 3-(2-bromoacetyl)coumarins, thiosemicarbazide and benzoylacetonitriles with excellent yields. All the synthesized compounds were screened for their anticancer activity against five human cancer cell lines [L1210, CEM, DU-145, HeLa, and MCF-7]. Among the tested compounds, 6-diethylamino substituted compound I (R = R2 = H; R1 = N(CH2CH3)2) exhibited excellent potency against tested cancer cell lines, whereas 6,8-ditert-Bu substituted compound I (R = R1 = C(CH3)3; R2 = H) showed promising activity against DU-145 and MCF-7 cancer cell lines with IC50 values of 7 +/- 1 and 9 +/- 6 μM. Mol. docking study was carried out in order to understand the most plausible binding site interactions of the compounds with human Epidermal growth factor receptor (EGFR). In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Product Details of 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Product Details of 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts